Lifeboat Foundation

The early detection and treatment of dementia such as Alzheimer’s is still one of the great challenges of modern medicine. It is already known that certain proteins in the cerebrospinal fluid can be used to diagnose Alzheimer’s disease. However, the current detection methods for such biomarkers by means of biochemical tests can only confirm and quantify the presence of such pathological proteins. No conclusions can be drawn about their original morphology of the proteins using biochemical assays, which holds information on disease stages.

However, such information if obtained directly in a label-free manner could allow conclusions to be drawn about the stage of the disease and evaluate the efficiency of a prescribed treatment. A team from the Transport at Nanoscale Interfaces Laboratory at Empa and the Department of Neurology at the Cantonal Hospital in St. Gallen has now used atomic force microscopy (AFM) to visualize the proteins that are indicative of Alzheimer’s disease under conditions that are as close to reality as possible. The researchers recently published their results in the journal Communications Biology.

With the new study, the researchers add another piece of the puzzle to their insights into Alzheimer’s development and diagnosis.

Scientists have uncovered the inner workings of one of the most important and intricate “nanobots” operating within our cells by using cutting-edge microscopy for visualizing molecules almost at an atomic level.

Their new study published in Nature has unveiled the critical step that switches on the spliceosome —a piece of cellular machinery that enables cells to build complex proteins.

By uncovering in detail how the spliceosome is activated, scientists believe the discovery could pave the way to more effective designs for cancer drugs that target it.

Year 2020 😗😁

Schizophrenia is one of the top 25 causes of global diseases burdens in terms of years lived with the disease and the emotional and economical strains it imposes on the society. Several strategies have been used to treat the patients, specially using typical and atypical psychoactives. However, due to its multifactorial characteristic and patient resistance, schizophrenia is still a difficult disease to diagnose and treat. Thus, new strategies for diagnostics and treatment must be researched to optimize the efficacy and reduce the side effects of the actual therapy. Nanomedicine tries to improve low-weight molecular agents for treatment of diseases through the use of nanoscaled carriers. Among nanomedicine, nanopsychiatry specifically deals with the potential role of nanotechnology in solving psychiatry diseases problems. Therefore, the objective of this work is to provide an overview of the state of the art of nanopsychiatry in the sense of treating schizophrenia.

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Root canal treatment removes the infection and bacteria from the core of a tooth — the pulp chamber. These bacteria are often present within the canals of the teeth. However, proper treatment saves a badly infected natural tooth from needing to be extracted. Sufficient cleaning of the root canals is a key step of RCT. A lack of proper canal debridement can cause bacteria to thrive — a significant cause of RCT failures.

The tooth is washed with antibiotics or other chemicals that kill the bacteria to get rid of the infection. However, some teeth have complex root structures, and conventional ways of cleaning them are not enough to remove all bacteria. That’s one area where dental nanorobots can help. Nanorobots are showing promise in different steps of RCT, even better than traditional ways.

Continue reading “Dental Nanorobots: An Innovation to Improve Root Canal Treatment” »

A time crystal, as originally proposed in 2012, is a new state of matter in which the particles are in continuous oscillatory motion. Time crystals break time-translation symmetry. Discrete time crystals do so by oscillating under the influence of a periodic external parametric force, and this type of time crystal has been demonstrated in trapped ions, atoms and spin systems.

Continuous time crystals are more interesting and arguably more important, as they exhibit continuous time-translation symmetry but can spontaneously enter a regime of periodic motion, induced by a vanishingly small perturbation. It is now understood that this state is only possible in an open system, and a continuous quantum-time-crystal state has recently been observed in a quantum system of ultracold atoms inside an optical cavity illuminated with light.

In a paper published in Nature Physics, researchers at University of Southampton in the U.K. showed that a classical metamaterial nanostructure can be driven to a state that exhibits the same key characteristics of a continuous time crystal.

A proposed technique would use light and nanowires to generate electron beams with nearly pure spin polarization.

In a polarized electron beam, the particles’ spins are not randomly oriented but favor a particular direction. The polarization serves as a useful property for studying the magnetism of materials or for probing the spins of atoms or nuclei. But such a beam typically has a low degree of polarization unless it is produced at a synchrotron facility. Theorists have proposed creating these beams using laser light, but so far these approaches have involved extremely intense lasers and have not been expected to produce high polarization. Now Deng Pan of East China Normal University and Hongxing Xu of Wuhan University, China, have proposed a method that reduces the required laser intensity by up to 10 billion times compared with previous laser-based approaches and that should produce a pair of beams that are nearly 100% polarized [1].

In Pan and Xu’s proposal, a wide laser beam broadsides an array of parallel conducting nanowires with 100-nm spacing and excites them to emit electromagnetic waves. An unpolarized electron beam is sent across the array, perpendicular to the wires, about 100 nm away from them. Some electrons absorb or emit photons, causing their spins to align parallel or antiparallel to the local electric field. They also gain or lose a photon’s worth of energy. This interaction with the radiation near the wires generates two new beams with nearly pure spin polarizations and slightly different energies, allowing them to be easily separated. Pan and Xu say that the technique should be implementable with current technology and that it may even lead to new ways of manipulating electrons.

2D materials, which are finer than even the thinnest onionskin paper, have garnered significant attention due to their remarkable mechanical attributes. However, these properties dissapate when the materials are layered, thus restricting their practical applications.

“Think of a graphite pencil,” says Teng Li, Keystone Professor at the University of Maryland’s (UMD) Department of Mechanical Engineering. “Its core is made of graphite, and graphite is composed of many layers of graphene.

Graphene is an allotrope of carbon in the form of a single layer of atoms in a two-dimensional hexagonal lattice in which one atom forms each vertex. It is the basic structural element of other allotropes of carbon, including graphite, charcoal, carbon nanotubes, and fullerenes. In proportion to its thickness, it is about 100 times stronger than the strongest steel.

Researchers at the KIT Institute of Nanotechnology (INT) now managed to characterize the formation of the SEI with a multi-scale approach. “This solves one of the great mysteries regarding an essential part of all liquid electrolyte batteries – especially the lithium-ion batteries we all use every day,” says Professor Wolfgang Wenzel, director of the research group “Multiscale Materials Modelling and Virtual Design ” at INT, which is involved in the large-scale European research initiative BATTERY 2030+ that aims to develop safe, affordable, long-lasting, sustainable high-performance batteries for the future.

The KIT researchers report on their findings in the journal Advanced Energy Materials.

To examine the growth and composition of the passivation layer at the anode of liquid electrolyte batteries, the researchers at INT generated an ensemble of over 50 000 simulations representing different reaction conditions. They found that the growth of the organic SEI follows a solution-mediated pathway: First, SEI precursors that are formed directly at the surface join far away from the electrode surface via a nucleation process.

A small team of chemists at the Russian Academy of Sciences, has found that metal atoms, not nanoparticles, play the key role in catalysts used in fine organic synthesis. In the study, reported in the Journal of the American Chemical Society, the group used multiple types of electron microscopy to track a region of a catalyst during a reaction to learn more about how it was proceeding.

Prior research has shown that there are two main methods for studying a reaction. The first is the most basic: As ingredients are added, the reaction is simply observed and/or measured. This can be facilitated through use of high-speed cameras. This approach will not work with nanoscale reactions, of course. In such cases, chemists use a second method: They attempt to capture the state of all the components before and after the reaction and then compare them to learn more about what happened.

This second approach leaves much to be desired, however, as there is no way to prove that the objects under study correspond with one another. In recent years, chemists have been working on a new approach: Following the action of a single particle during the reaction. This new method has proven to have merit but it has limitations as well—it also cannot be used for reactions that occur in the nanoworld. In this new effort, the researchers used multiple types of electron microscopy coupled with machine-learning algorithms.