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Category: health

Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction. The map marks a major step in the understanding of genetic diversity and its impact on health and fertility. It continues 25 years of research at deCODE genetics into how new diversity is generated in the human genome, and its relationship to health and disease.

The new map, appearing today in the online edition of Nature, is the first to incorporate shorter-scale shuffling, (non crossover) of grandparental DNA, which is difficult to detect due to the high DNA sequence similarity. The map also identifies areas of DNA that are devoid of major reshuffling, likely to protect critical genetic functions or prevent chromosomal problems. This insight offers a clearer picture of why some pregnancies fail and how the genome balances diversity with stability.

While this shuffling, known as , is essential for genetic diversity, errors in the process can lead to serious reproductive issues. These failures can result in genetic errors that prevent pregnancies from continuing, helping to explain why infertility affects around one in ten couples worldwide. Understanding this process offers new hope for improving fertility treatments and diagnosing pregnancy complications.

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Like humans, mice will compete over territory and mates, and show increased confidence in their fighting skills the more they win. At first, a brain chemical called dopamine is essential for young males to master this behavior. But as they gain experience, the chemical grows less important in promoting aggression, a new study shows.

Dopamine has been linked to male aggression for decades. How past experiences might influence this relationship, however, had until now been unclear.

In experiments in rodents, a team led by researchers at NYU Langone Health boosted activity in -releasing cells in a part of the brain called the . The findings revealed that in inexperienced male fighters, this led the animals to attack for twice as long as they would have fought naturally. When the cells were blocked, the novice mice would not fight at all.

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The ability to regulate one’s own food intake is essential to the survival of both humans and other animals. This innate ability ensures that the body receives the nutrients it needs to perform daily activities, without significantly exceeding calorie intake, which could lead to health problems and metabolic disorders.

Past neuroscience studies suggest that the regulation of food intake is supported by specific regions in the brain, including the hypothalamus and caudal nucleus of the solitary tract (cNTS), which is part of the brainstem. This key region in the brainstem is known to integrate originating from the gut and then transform them into adaptive feeding behaviors.

While previous research has highlighted the key role of the cNTS in food intake regulation, the unique contribution of the different neuron subtypes within this brainstem region and the mechanisms by which they regulate feeding remain poorly understood. Better understanding these neuron-specific mechanisms could help to devise more effective therapeutic interventions for obesity and eating disorders.

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Past research suggests that meditation and exposure to art or nature can positively impact people’s well-being and brain health, in some cases even reducing stress and supporting the processing of emotions. Yet most past studies focused on each of these experiences individually, rather than comparing their effects on brain activity.

Researchers at University of California Los Angeles set out to examine the brain activation patterns associated with a visualization-based of connecting to the cosmic soul and compare them to those from people watching evocative digital art or nature videos.

Their findings, published in Frontiers in Human Neuroscience, suggest that these different types of transcending experiences prompt different brain activation patterns.

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Mechanisms underlying gut microbiota’s role in obesity

Energy absorption and short-chain fatty acids

Gut microbiota regulate energy metabolism through short-chain fatty acids (SCFAs) like acetate, butyrate, and propionate, which are products of fiber fermentation. While butyrate promotes insulin sensitivity and reduces inflammation, propionate may trigger overeating. Dysregulated SCFA production can contribute to obesity by enhancing energy absorption, disrupting appetite regulation, and promoting fat accumulation. Recent findings suggest that modulating SCFA production through dietary interventions can help regulate energy balance and improve metabolic health. Maintaining SCFA balance through diet or microbial modulation holds promise for obesity management.

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Dive into the fascinating world of the Cori Cycle, also known as the lactic acid cycle! 🏋️‍♂️💡 In this video, we’ll explore how your body manages energy during intense exercise by recycling lactate from muscles back into glucose in the liver.
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It’s become increasingly clear that the gut microbiome can affect human health, including mental health. Which bacterial species influence the development of disease and how they do so, however, is only just starting to be unraveled.

For instance, some studies have found compelling links between one species of gut bacteria, Morganella morganii, and major depressive disorder. But until now, no one could tell whether this bacterium somehow helps drive the disorder, the disorder alters the microbiome, or something else is at play.

Harvard Medical School researchers have now pinpointed a biologic mechanism that strengthens the evidence that M. morganii influences brain health and provides a plausible explanation for how it does so.

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Trump—flanked by larry ellison, sam altman, & masayoshi son—announces project stargate.

Trump announces Project Stargate, a $500 billion initiative backed by major tech leaders, aimed at revolutionizing U.S. AI infrastructure, creating jobs, and enhancing healthcare through advanced technologies. AI Infrastructure and Economic Impact.

🏗️Project Stargate, a $500+ billion AI infrastructure initiative, aims to construct colossal data centers and physical campuses across the US, potentially creating over 100,000 American jobs.

🌐The project will build physical and virtual infrastructure to power next-generation AI advancements, with Oracle, SoftBank, and Microsoft as key partners, establishing a new US-centered industry. ## Healthcare Applications.

Continue reading “BREAKING: Trump—Flanked By Larry Ellison, Sam Altman, & Masayoshi Son—Announces Project Stargate” | >