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Category: 3D printing

Physicists use 3D-printed spines to sculpt water surface through surface tension

Physicists at the University of Liège have succeeded in sculpting the surface of water by exploiting surface tension. Using 3D printing of closely spaced spines, they have combined menisci to create programmed liquid reliefs, capable of guiding particles under the action of gravity alone. This is a promising advance for microscopic transport and sorting, as well as marine pollution control. The research is published in the journal Nature Communications.

Have you ever tried tilting a liquid in a glass? It’s completely impossible. If you tilt the glass, the surface of the liquid will automatically return to the horizontal … except for a small—barely visible—curvature that forms near the edge of the glass. This curvature is called a meniscus. And this meniscus is due to capillarity, a force acting on a millimeter scale and resulting from the of the liquid.

What would happen if we could create lots of little menisci over a large surface? What if these small reliefs could add up to form slopes, valleys, or even entire landscapes … liquid? This is exactly what scientists from the GRASP laboratory at the University of Liège, in collaboration with Brown University (U.S.), have succeeded in doing.

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Alternative models for studying aging have employed unicellular organisms such as the budding yeast Saccharomyces cerevisiae. Studying replicative aging in yeast has revealed insights into evolutionarily conserved enzymes and pathways regulating aging[ 12-14 ] as well as potential interventions for mitigating its effects.[ 15 ] However, traditional yeast lifespan analysis on agar plates and manual separation cannot track molecular markers and yeast biology differs from humans.[ 16 ]

Animal models, including nematodes, flies, and rodents, play a vital role in aging research due to their shorter lifespans and genetic manipulability, making them useful for mimicking human aging phenotypes.[ 17 ] These models have provided many insights into the fundamental understanding of aging mechanism. However, animal models come with several limitations when applied to human aging and age-related diseases. Key issues include limited generalizability due to species-specific differences in disease manifestation and physiological traits. For example, animal models often exhibit physiological differences, age at different rates, and may not fully replicate human conditions like cardiovascular disease,[ 18 ] immune response,[ 19 ] neurodegenerative diseases,[ 20 ] and drug metabolism.[ 21 ] Furthermore, in vivo models, such as rodents and non-human primates, suffer from limitations such as high costs, low throughput, ethical concerns, and physiological differences compared to humans. The use of shorter lifespan or accelerated aging models, along with the absence of long-term longitudinal data, can further distort the natural aging process and hinder our understanding of aging in humans. Additionally, many animal models rely on inbred strains, which lack genetic diversity and may not fully represent evolutionary complexity.[ 22 ]

In recent years, microfluidics has emerged as a promising tool for studying aging, offering of physiologically relevant 3D environments with high-throughput capabilities that surpass the limitations of traditional 2D cultures and bridge the gap between animal models and human As a multidisciplinary technology, microfluidics processes or manipulates small volumes of fluids (from pico to microliters) within channels measuring 10–1000 µm.[ 23 ] Traditional fabrication methods, such as photolithography and soft lithography, particularly using polydimethylsiloxane (PDMS), remain widely used due to their cost-effectiveness and biocompatibility. However, newer approaches, including 3D printing, injection molding, and laser micromachining, offer greater flexibility for rapid prototyping and the creation of complex architectures. Design considerations are equally critical and are tailored to the specific application, focusing on parameters such as channel geometry, fluid dynamics, material properties, and the integration of on-chip components like valves, sensors, and actuators. A comprehensive overview of the design and fabrication of microphysiological systems is beyond the scope of this review; readers are referred to existing reviews for further detail.[ 24-26 ] Microfluidic devices offer numerous advantages, including reduced resource consumption and costs, shorter culture times, and improved simulation of pathophysiological conditions in 3D cellular systems compared to other model systems (Figure 1).[ 27 ] Therefore, microfluidics platforms have been extensively employed in various domains of life science research, such as developmental biology, disease modeling, drug discovery, and clinical applications,[ 28 ] positioning this technology as a significant avenue in the field of aging research.

Algorithm streamlines vascular system design for 3D printed hearts

There are more than 100,000 people on organ transplant lists in the U.S., some of whom will wait years to receive one—and some may not survive the wait. Even with a good match, there is a chance that a person’s body will reject the organ. To shorten waiting periods and reduce the possibility of rejection, researchers in regenerative medicine are developing methods to use a patient’s own cells to fabricate personalized hearts, kidneys, livers, and other organs on demand.

Ensuring that oxygen and nutrients can reach every part of a newly grown organ is an ongoing challenge. Researchers at Stanford have created new tools to design and 3D print the incredibly complex vascular trees needed to carry blood throughout an organ. Their platform, published June 12 in Science, generates designs that resemble what we actually see in the human body significantly faster than previous attempts and is able to translate those designs into instructions for a 3D printer.

“The ability to scale up bioprinted tissues is currently limited by the ability to generate vasculature for them—you can’t scale up these tissues without providing a ,” said Alison Marsden, the Douglas M. and Nola Leishman Professor of Cardiovascular Diseases, professor of pediatrics and of bioengineering at Stanford in the Schools of Engineering and Medicine and co-senior author on the paper. “We were able to make the algorithm for generating the vasculature run about 200 times faster than prior methods, and we can generate it for complex shapes, like organs.”

Light-guided 3D printing method creates recyclable supports for complex designs

Hearing aids, mouth guards, dental implants, and other highly tailored structures are often products of 3D printing. These structures are typically made via vat photopolymerization—a form of 3D printing that uses patterns of light to shape and solidify a resin, one layer at a time.

The process also involves printing structural supports from the same material to hold the product in place as it’s printed. Once a product is fully formed, the supports are removed manually and typically thrown out as unusable waste.

MIT engineers have found a way to bypass this last finishing step, in a way that could significantly speed up the 3D-printing process. They developed a resin that turns into two different kinds of solids, depending on the type of light that shines on it: Ultraviolet light cures the resin into an highly resilient solid, while visible light turns the same resin into a solid that is easily dissolvable in certain solvents.

DARPA Wants ‘Large Bio-Mechanical Space Structures’

These are your rudimentary seed packages… Some will combine in place to form more complicated structures.’ — Greg Bear, 2015.

Robot Bricklayer Or Passer-By Bricklayer? ‘Oscar picked up a trowel. ‘I’m the tool for the mortar,’ the little trowel squeaked cheerfully.’ — Bruce Sterling, 1998.

Organic Non-Planar 3D Printing ‘It makes drawings in the air following drawings…’ — Murray Leinster, 1945.

3D printers leave hidden ‘fingerprints’ that reveal part origins

A new artificial intelligence system pinpoints the origin of 3D printed parts down to the specific machine that made them. The technology could allow manufacturers to monitor their suppliers and manage their supply chains, detecting early problems and verifying that suppliers are following agreed upon processes.

A team of researchers led by Bill King, a professor of mechanical science and engineering at the University of Illinois Urbana-Champaign, has discovered that parts made by , also known as 3D printing, carry a unique signature from the specific machine that fabricated them. This inspired the development of an AI system which detects the signature, or “fingerprint,” from a photograph of the part and identifies its origin.

“We are still amazed that this works: we can print the same part design on two identical machines –same model, same process settings, same material—and each machine leaves a unique fingerprint that the AI model can trace back to the machine,” King said. “It’s possible to determine exactly where and how something was made. You don’t have to take your supplier’s word on anything.”

World’s tallest 3D-printed building reaches a height of 100 feet

Likened by its creators to an “ornate layered cake,” the Tor Alva has been completed in Switzerland. Hailed as the world’s tallest 3D-printed building, this remarkable structure rises to an impressive height of 30 m (98.5 ft).

Tor Alva (aka White Tower) is located in the small alpine village of Mulegns that’s currently home to just 11 people. It was created by researchers at ETH Zurich, in collaboration with cultural foundation Fundaziun Origen, to show off the capabilities of cutting-edge 3D-printing techniques.

Architect Michael Hansmeyer and ETH Professor of Digital Building Technologies Benjamin Dillenburger designed its actual form, which consists of an intricate structure of 32 white concrete columns that rise over four floors and taper before fanning out to top out with a dome. The interior, meanwhile, has a capacity for 32 visitors and includes stairs on each floor, with a performance space at the top.