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Category: sex

Cerebral Microvascular Perfusion Assessed in Elderly Adults by Spin-Echo Dynamic Susceptibility Contrast MRI at 7 Tesla

Perfusion measures of the total vasculature are commonly derived with gradient-echo (GE) dynamic susceptibility contrast (DSC) MR images, which are acquired during the early passes of a contrast agent. Alternatively, spin-echo (SE) DSC can be used to achieve specific sensitivity to the capillary signal. For an improved contrast-to-noise ratio, ultra-high-field MRI makes this technique more appealing to study cerebral microvascular physiology. Therefore, this study assessed the applicability of SE-DSC MRI at 7 T. Forty-one elderly adults underwent 7 T MRI using a multi-slice SE-EPI DSC sequence. The cerebral blood volume (CBV) and cerebral blood flow (CBF) were determined in the cortical grey matter (CGM) and white matter (WM) and compared to values from the literature. The relation of CBV and CBF with age and sex was investigated.

Sons of mothers with type 1 diabetes show early signs of vascular dysfunction

“Our work shows that vascular function is affected before metabolic dysfunction appears, which challenges current assumptions,” the last author of the study.

The study found that the dysfunction is driven by oxidative stress in endothelial cells, a potential early sign of future cardiovascular disease. The findings could help clinicians better assess risk and focus on preventive measures.

“We observed that early intervention can restore vascular function in affected animals, pointing to new opportunities for disease prevention later in life,” adds the first author.

A new study i reveals that sons born to mothers with type 1 diabetes may develop early vascular dysfunction – independently of metabolic health. The finding, published in Cell Reports Medicine, may help shape future strategies to prevent cardiovascular disease early in life.

Children of women with type 1 diabetes are known to be at increased risk of developing cardiovascular diseases. This new study is, according to the researchers, the first to show that the risk is linked to early dysfunction in blood vessel cells in sons, even before any metabolic issues arise.

Researchers used a combination of animal models, Swedish and Danish health registries, and a small clinical study to explore the link. Results show a sex-specific effect: only sons displayed early vascular changes.

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Schizophrenia-spectrum disorders may originate in specific brain regions that show early structural damage

Researchers at the University of Seville have identified the possible origins of structural damage in the brains of patients with schizophrenia spectrum disorders (SSDs). These are regions that show the greatest morphological alterations in the early stages of the disease compared to neurotypical people of the same sex and age. The study also found that people with SSD have significant reductions in structural similarity between different regions of the temporal, cingulate and insular lobes.

The research is published in the journal Nature Communications.

Children With Autism, ADHD, And Anorexia Share a Common Microbe Imbalance

The ratio of two dominant groups of microbes in the human gut was higher across all three disorder groups than was typically seen in the control group.

A new, small study suggests children with autism, ADHD, and anorexia share similarly disrupted gut microbiomes, which, by some measures, have more in common with each other than with their healthy, neurotypical peers.

Led by researchers from Comenius University in Slovakia, the study used stool samples to assess the gut microbiomes of 117 children.

The exploratory study included 30 boys with autism spectrum disorder (ASD), 21 girls with anorexia nervosa, and 14 children with attention deficit hyperactivity disorder (ADHD). The remaining samples were from age-and sex-matched healthy and neurotypical children, providing a control group.

Scientists Call Age-25 Cannabis Rules a Myth

“This Perspective concludes that an MLA between 18–21 years is a scientifically supportable and socially coherent threshold for non-medical cannabis use.”

What should be the minimum legal age for recreational cannabis? This is what a recent study published in The American Journal on Drug and Alcohol Abuse hopes to address as a team of scientists investigated the benefits and challenges of raising the legal age for using recreational marijuana to 25, with the current age range being 18 to 21, depending on the country. This study has the potential to help researchers, legislators, and the public better understand the neuroscience behind the appropriate age for cannabis use.

For the study, the researchers examined brain development for individuals aged 18–25, specifically regarding brain maturation and whether this ceases before age 25. They note it depends on a myriad of factors, including sex, geographic region, and physiology. This study comes as Germany recently published several studies regarding legalizing recreational marijuana nationwide and marijuana use rates post-legalization. In the end, the researchers for this most recent study concluded that raising the minimum legal age for recreational cannabis use to 25 is unnecessary.

The study notes, “This Perspective concludes that an MLA between 18–21 years is a scientifically supportable and socially coherent threshold for non-medical cannabis use. Policy decisions should be informed not only by neurobiological evidence but also by legal, justice, sociocultural, psychological, and historical considerations.”

Bisphenol A causes sex-specific changes in metabolism and the immune system, study reveals

Even small amounts of bisphenol A can lead to long-term health effects. When researchers studied adult rats exposed in the fetal stage, they found that females had developed a more masculine and males a more feminine gene expression pattern. This led to females progressing towards a cancer-like state, while males progressed towards metabolic syndrome, which can increase the risk of diabetes and heart disease.

Bisphenol A is a synthetic chemical with estrogen-like properties that is commonly used in food packaging materials. The substance is banned in many products, but is still present in some packaging. Levels of bisphenol A in people’s bodies are often above levels considered safe, with previous research showing that the substance can cause adverse health effects.

Females masculinized and males feminized In the current study, published in Communications Medicine, researchers investigated how bisphenol A affects the body during the fetal stage.

Spaceflight study reveals men experience greater eye changes, while brain differences between sexes are subtle

A new study into how spaceflight impacts the human brain and eyes revealed notable sex differences in brain fluid shifts, with female astronauts showing a greater reduction in fluid around the uppermost part of the brain than their male counterparts.

Led by Rachael D. Seidler, Ph.D., director of the University of Florida’s Astraeus Space Institute and professor of applied physiology and kinesiology, the study analyzed data from astronauts to determine how factors such as sex, age and body metrics relate to structural and eye changes after .

The findings, published in npj Microgravity, provide key information for protecting astronaut health on long-duration missions to the moon and Mars.

In-utero exposure to maternal diabetes and DNA methylation alterations in the Next Generation birth cohort

The incidence of type 2 diabetes (T2D) in youth is increasing and in-utero exposure to maternal diabetes is a known risk factor, with higher risk associated with pregestational T2D exposure compared to gestational diabetes mellitus (GDM) exposure. We hypothesize this differential risk is reflected in DNA methylation (DNAm) changes induced by differential timing of in-utero exposure to maternal diabetes, and that exposure to diabetes throughout pregnancy (T2D) compared to exposure later in development (GDM), induces different DNAm signatures and different T2D risk to offspring. This study presents an epigenome-wide investigation of DNAm alterations associated with in-utero exposure to either maternal pregestational T2D or GDM, to determine if the timing of prenatal diabetes exposure differentially alters DNAm.

We performed an epigenome-wide analysis on cord blood from 99 newborns exposed to pregestational T2D, 70 newborns exposed to GDM, and 41 unexposed to diabetes in-utero from the Next Generation birth cohort. Associations were tested using multiple linear regression models while adjusting for sex, maternal age, BMI, smoking status, gestational age, cord blood cell type proportions and batch effects.

We identified 27 differentially methylated sites associated with exposure to GDM, 27 sites associated with exposure to T2D, and 9 common sites associated with exposure to either GDM or T2D (adjusted p value 0.01). One site at CLDN15 and two unannotated sites were previously reported as associated with obesity. We also identified 87 differentially methylated regions (DMRs) associated with in-utero exposure to GDM and 69 DMRs associated with in-utero exposure to T2D. We identified 23 DMR sites that were previously associated with obesity, three with T2D and five with in-utero exposure to GDM. Furthermore, we identified six CpG sites in the PTPRN2 gene, a gene previously associated with DNAm differences in blood of youth with T2D from the same population.

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