Lifeboat Foundation

A NIAID-funded study suggests a strategy to mitigate harmful side effects of nanoparticles in medicine. The researchers showed in animal models that a lab-made molecule safely prevented nanomedicines from activating a set of immune-system proteins called the complement system and causing negative side effects. This is significant because when nanoparticles activate complement, the resulting immune response can not only cause an adverse reaction, but also reduce the efficacy of nanomedicines.

The molecular synthesizer once thought to be impossible to make is now quite a possibility due to this discovery with electron beams that can heal crystalline structures and also build objects from electron beams this could one day be amplified to create even food with light into matter electron beams. Also this could create even life or even rebirth a universe or planet or sun really eventually anything that is matter. Really it is a molecular assembler with nearly limitless applications.

Electron beams can be used to heal nano-fractures in crystals instead of causing further damage to them, as initially expected by researchers who now report their surprise findings. Used to power microscopes that examine the smallest materials in the universe, electron beams may also be able to be used to create novel microstructures one atom at a time.

A feat once thought impossible, researchers at the University of Minnesota Twin Cities (UMN) behind the discovery said it had been assumed that using electron beams to study nanostructures carried the additional risk of exacerbating microscopic cracks and flaws already in the material.

Continue reading “Electron Beams Magically Heal Microscopic Fractures, May Also Enable Creation of Objects One Atom at a Time” »

Nanozymes are synthetic materials that mimic the properties of natural enzymes for applications in biomedicine and chemical engineering. Historically, they are generally considered too toxic and expensive for use in agriculture and food science. Now, researchers from the University of Illinois Urbana-Champaign have developed a nanozyme that is organic, non-toxic, environmentally friendly, and cost effective.

In a newly published paper, they describe its features and its capacity to detect the presence of glyphosate, a common agricultural herbicide. Their goal is to eventually create an user-friendly test kit for consumers and agricultural producers.

“The word nanozyme is derived from nanomaterial and enzyme. Nanozymes were first developed about 15 years ago, when researchers found that iron oxide nanoparticles may perform catalytic activity similar to natural enzymes (peroxidase),” explained Dong Hoon Lee, a doctoral student in the Department of Agricultural and Biological Engineering (ABE), part of the College of Agricultural, Consumer and Environmental Sciences (ACES) and The Grainger College of Engineering at U. of I.

Researchers from Tokyo Metropolitan University have engineered a range of new single-walled transition metal dichalcogenide (TMD) nanotubes with different compositions, chirality, and diameters by templating off boron-nitride nanotubes. They also realized ultra-thin nanotubes grown inside the template, and successfully tailored compositions to create a family of new nanotubes. The ability to synthesize a diverse range of structures offers unique insights into their growth mechanism and novel optical properties.

The work is published in the journal Advanced Materials.

The carbon nanotube is a wonder of nanotechnology. Made by rolling up an atomically thin sheet of carbon atoms, it has exceptional mechanical strength and electrical conductivity among a range of other exotic optoelectronic properties, with potential applications in semiconductors beyond the silicon age.

A research group at the Institute for Molecular Science has successfully observed the left and right handedness of material structures at the nanoscale, by illuminating chiral gold nanostructures with circularly polarized light and detecting the optical force acting on a probe near the nanostructures. This result demonstrated that it is possible to analyze the chiral structure of matter at the nanoscale using light.

Chirality describes the property of a material structure not being superimposable onto its mirror image. Since the left and right hands, which are mirror images of each other, do not coincide (they are not the same), they are chiral.

Chiral objects can be distinguished to right-or left-handedness. Many substances that constitute life are chiral, and often only one of either the right-or left-handedness naturally exists. Also, in new functional materials, their chiral nature often plays an important role for the functions.

Scientists at the IBS Center for Quantum Nanoscience (QNS) at Ewha Womans University have accomplished a groundbreaking step forward in quantum information science. In partnership with teams from Japan, Spain, and the US, they created a novel electron-spin qubit platform, assembled atom.

An atom is the smallest component of an element. It is made up of protons and neutrons within the nucleus, and electrons circling the nucleus.

Adopting a nanoscale approach to developing materials and designing experiments benefits research on batteries, supercapacitors and hybrid devices at all technology readiness levels.

There is an urgent need to address climate change, making the development of sustainable energy alternatives more important than ever. While proton-exchange membrane fuel cells (PEMFCs) have shown great promise for energy production, particularly in the transportation industry, there is a long-standing problem with their durability and cost.

A Western research team has addressed the issue with a new cobalt-modified nanomaterial making PEMFCs more robust, readily sourced and environmentally sustainable demonstrating just a two percent loss in efficiency rate following 20,000 cycles in a durability test.

The new nanomaterial is used to enhance oxygen reduction reaction (ORR), the process that forms water in the fuel cell allowing a higher current for more efficient power generation. The cobalt-modified nanomaterial also reduces the reliance on platinum to construct these fuel cells. A costly precious metal, and mined primarily in South Africa, only a few hundred tons of platinum are produced annually.

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In this webinar, three experts will discuss how Precision NanoSystems’ modular microfluidic platform technologies and analytics can help scientists successfully design, develop, test, and scale-up promising mRNA-LNP vaccines and therapeutics from concept to clinic. Don’t miss this webinar, now available on demand.

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Nucleic acids (e.g., siRNA, mRNA and saRNA) can be designed and formulated to silence, express, and edit specific genes providing a flexible and powerful approach to preventing and treating diseases. The recent commercialization and widespread distribution of COVID-19 mRNA vaccines has exemplified the massive potential of this new class of genomic medicines and vaccines to effectively thwart emerging viral threats and treat a wide range of challenging diseases. Part of developing a successful mRNA therapeutic or vaccine is choosing a delivery mechanism that protects the nucleic acids on the way to their target tissue. Encapsulating mRNA in lipid nanoparticles has proven to be one of the best vehicles for overcoming extracellular and intracellular barriers and safely delivering the treatment. Several mRNA-LNP formulations that target things like viral infections and cancers are being evaluated clinically.

Continue reading “Accelerating mRNA-LNP Medicine Development from Concept to Clinic” »