Lifeboat Foundation

Despite exciting advances in gene editing, the efficient delivery of genetic tools to extrahepatic tissues remains challenging. This holds particularly true for the skin, which poses a highly restrictive delivery barrier. In this study, we ran a head-to-head comparison between Cas9 mRNA or ribonucleoprotein (RNP)-loaded lipid nanoparticles (LNPs) to deliver gene editing tools into epidermal layers of human skin, aiming for in situ gene editing. We observed distinct LNP composition and cell-specific effects such as an extended presence of RNP in slow-cycling epithelial cells for up to 72 h. While obtaining similar gene editing rates using Cas9 RNP and mRNA with MC3-based LNPs (10–16%), mRNA-loaded LNPs proved to be more cytotoxic. Interestingly, ionizable lipids with a p K_a ∼ 7.1 yielded superior gene editing rates (55%–72%) in two-dimensional (2D) epithelial cells while no single guide RNA-dependent off-target effects were detectable. Unexpectedly, these high 2D editing efficacies did not translate to actual skin tissue where overall gene editing rates between 5%–12% were achieved after a single application and irrespective of the LNP composition. Finally, we successfully base-corrected a disease-causing mutation with an efficacy of ∼5% in autosomal recessive congenital ichthyosis patient cells, showcasing the potential of this strategy for the treatment of monogenic skin diseases. Taken together, this study demonstrates the feasibility of an in situ correction of disease-causing mutations in the skin that could provide effective treatment and potentially even a cure for rare, monogenic, and common skin diseases.

Using nanoparticles administered directly into the cerebrospinal fluid (CSF), a research team has developed a treatment that may overcome significant challenges in treating a particularly deadly brain cancer.

The researchers, led by professors Mark Saltzman and Ranjit Bindra, administered to mice with medulloblastoma a treatment that features specially designed drug-carrying nanoparticles. The study, published in Science Translational Medicine, showed that mice who received this treatment lived significantly longer than mice in the control group.

Medulloblastoma, a brain cancer that predominantly affects children, often begins with a tumor deep inside the brain. The cancer is prone to spread along two protective membranes known as the leptomeninges throughout the central nervous system, particularly the surface of the brain and the CSF.

Engineers at the University of California San Diego have developed modular nanoparticles that can be easily customized to target different biological entities such as tumors, viruses or toxins. The surface of the nanoparticles is engineered to host any biological molecules of choice, making it possible to tailor the nanoparticles for a wide array of applications, ranging from targeted drug delivery to neutralizing biological agents.

The beauty of this technology lies in its simplicity and efficiency. Instead of crafting entirely new nanoparticles for each specific application, researchers can now employ a modular nanoparticle base and conveniently attach proteins targeting a desired biological entity.

In the past, creating distinct nanoparticles for different biological targets required going through a different synthetic process from start to finish each time. But with this new technique, the same modular nanoparticle base can be easily modified to create a whole set of specialized nanoparticles.

For the first time, a physical neural network has successfully been shown to learn and remember “on the fly,” in a way inspired by and similar to how the brain’s neurons work.

The result opens a pathway for developing efficient and low-energy machine intelligence for more complex, real-world learning and memory tasks.

Published today in Nature Communications, the research is a collaboration between scientists at the University of Sydney and University of California at Los Angeles.

Nanotechnology sounds like a futuristic development, but we already have it in the form of CPU manufacturing. More advanced nanotech could be used to create independent mobile entities like nanobots. One of the main challenges is selecting the right chemicals, elements, and structures that actually perform a desired task. Currently, we create more chemically oriented than computationally oriented nanobots, but we still have to deal with the quantum effects at tiny scale.

One of the most important applications of nanotechnology is to create nanomedicine, where the technology interacts with biology to help resolve problems. Of course, the nanobots have to be compatible with the body (e.g. no poisonous elements if they were broken down, etc).

Continue reading “How nanobots and nanomedicine will improve our health” »

The convergence of Biotechnology, Neurotechnology, and Artificial Intelligence has major implications for the future of humanity. This talk explores the long-term opportunities inherent to these fields by surveying emerging breakthroughs and their potential applications. Whether we can enjoy the benefits of these technologies depends on us: Can we overcome the institutional challenges that are slowing down progress without exacerbating civilizational risks that come along with powerful technological progress?

About the speaker: Allison Duettmann is the president and CEO of Foresight Institute. She directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, Fellowships, Prizes, and Tech Trees, and shares this work with the public. She founded Existentialhope.com, co-edited Superintelligence: Coordination & Strategy, co-authored Gaming the Future, and co-initiated The Longevity Prize. She advises companies and projects, such as Cosmica, and The Roots of Progress Fellowship, and is on the Executive Committee of the Biomarker Consortium. She holds an MS in Philosophy & Public Policy from the London School of Economics, focusing on AI Safety.

Particle accelerators are crucial tools in a wide variety of areas in industry, research and the medical sector. The space these machines require ranges from a few square meters to large research centers. Using lasers to accelerate electrons within a photonic nanostructure constitutes a microscopic alternative with the potential of generating significantly lower costs and making devices considerably less bulky.

Until now, no substantial energy gains were demonstrated. In other words, it has not been shown that electrons really have increased in speed significantly. A team of laser physicists at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) has now succeeded in demonstrating the first nanophotonic electron accelerator —at the same time as colleagues from Stanford University. The researchers from FAU have now published their findings in the journal Nature.

When people hear “particle accelerator,” most will probably think of the Large Hadron Collider in Geneva, the approximately 27 kilometer long ring-shaped tunnel which researchers from around the globe used to conduct research into unknown elementary particles. Such huge particle accelerators are the exception, however. We are more likely to encounter them in other places in our day to day lives, for example in medical imaging procedures or during radiation to treat tumors.

Link :- https://eng.unimelb.edu.au/ingenium/wearable-device-makes-me…f-a-finger

Researchers from the University of Melbourne and RMIT University have invented an experimental wearable device that generates power from a user’s bending finger and can create and store memories, in a promising step towards health monitoring and other technologies.

Multifunctional devices normally require several materials in layers, which involves the time-consuming challenge of stacking nanomaterials with high precision. This innovation features a single nanomaterial incorporated into a stretchable casing fitted to a person’s finger. The nanomaterial enables the device to produce power simply through the user bending their finger. The super-thin material also allows the device to perform memory tasks.

Continue reading “Wearable device makes memories and powers up with the flex of a finger” »

A team of researchers from TU Delft, University of Illinois, and MPI Göttingen has developed a nanoscale turbine made of DNA that can rotate in both directions depending on the salt concentration in the solution. This remarkable feat of nanotechnology could pave the way for new applications in drug delivery, biomimetics, and energy harvesting.

Natural turbines using DNA origami

A turbine is a device that converts the kinetic energy of a fluid into mechanical work. These are ubiquitous in our modern world, from wind farms to jet engines. They are also essential for life, as some biological molecules act as turbines to power cellular functions, such as the ATP synthase that produces energy for cells and the bacterial flagella that propel bacteria.

Continue reading “Nanotechnology breakthrough: DNA turbine changes direction with salt” »