Lifeboat Foundation

Scientists at Nanyang Technological University, Singapore (NTU Singapore) have found that a stress response in cells, when ‘switched on’ at a post-reproductive age, could be the key to slowing down aging and promoting longevity.

Longevity. Technology: In lab experiments on a type of roundworm that shares similarities with humans – paging C elegans – the NTU Singapore team found that switching on this stress response in aged worms by feeding them a high-glucose diet extended their lifespan as compared with worms fed a normal diet.

Publishing today in Nature Communications, the NTU team say this is the first time a link between this stress response and aging has been uncovered.

Patients with a specific form of age-related macular degeneration (AMD), a leading cause of blindness in the United States, are also highly likely to have either underlying heart damage from heart failure and heart attacks, or advanced heart valve disease, or carotid artery disease associated with certain types of strokes, according to a new study from New York Eye and Ear Infirmary of Mount Sinai.

This research, published November 17 in BMJ Open Ophthalmology, is the first to identify which types of high-risk cardiovascular and carotid artery disease are linked to the eye disorder. The findings could prompt increased screening to save vision, diagnose undetected heart disease, and prevent adverse cardiovascular events.

“For the first time, we have been able to connect these specific high-risk cardiovascular diseases to a specific form of AMD, the one with subretinal drusenoid deposits (SDDs),” explains lead author R. Theodore Smith, MD, Ph.D., Professor of Ophthalmology at the Icahn School of Medicine at Mount Sinai.

Summary: A new study will investigate the genetic and biological mysteries of extreme longevity and healthy aging.

Source: american federation for aging research.

Decades of research will be aided by the results of a study launched today – the most ambitious ever conducted to uncover and understand the genetic and biological mysteries of exceptional longevity and healthy aging.

Transhumanists are redefining what it means to be human. This talk takes a deeper look at the movement and its implications for the future.
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From bionic eyes to designing new senses and extending life expectancy, transhumanists are redefining what it means to be human. This talk takes a deeper look at the movement and its implications for the future of humanity.

Continue reading “Transhumanism & The Future of Humanity” »

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The common longevity supplement NMN has recently been banned by the FDA for several reasons which have sent ripples through the longevity, sparking outrage and several concerns as to where the longevity industry is heading.

Aging is a complex process that can lead to chronic diseases such as diabetes, cardiovascular disorders, muscular degeneration, atherosclerosis and neurodegeneration, and it is currently one of the major scientific concerns in the field of medicine [1].

Several strategies have been developed to date for the promotion of healthy aging and an increase in the duration of life. One of the recent strategies that can decrease the deleterious impact of aging and increase the regenerative property at the cellular level is cellular reprogramming.

Cellular reprogramming can convert a somatic cell into an induced pluripotent stem cell (iPSC). It not only helps to restore tissue and organ function but also helps to determine cell fate. This, in turn, helps in the maintenance of cellular identity through the expression of cell type-specific genes and suppression of lineage-inappropriate genes [2].

A bit concerning cellular reprogramming after a few minutes, and stating a goal just before 7:00 a stated goal of reversing aging across the entire human.

“There are no hard limits imposed by biology or by physics that says that we can’t live better longer,” Kristen Fortney, CEO of San Francisco-based BioAge Labs, told the outlet. Focused on discerning the markers of aging, BioAge Labs is using large amounts of biobank blood and tissue samples to do so.

The company has already found a drug target that slows aging-linked muscle loss in mice.

“There is a protein called apelin that circulates in the blood, and we saw that middle-aged people with higher levels of apelin in their blood were living longer, with better muscle function and better cognitive function as they age,” Fortney said, according to Express.