Lifeboat Foundation

A multinational team headed by University College London scientists has discovered a new mechanism that slows down and maybe even prevents the normal aging of immune cells, one of the nine “hallmarks of aging.”

The discovery in-vitro (cells) and validated in mice was “unexpected,” according to the researchers, who believe harnessing the mechanism might extend the life of the immune system, enabling people to live healthier and longer lives, and would also have therapeutic use for diseases such as cancer and dementia. Their findings were recently published in the journal Nature Cell Biology.

Explaining the study, lead author, Dr. Alessio Lanna, Honorary Professor at UCL Division of Medicine, said: Immune cells are on constant high-alert, always ready to fight pathogens. To be effective they also must persist for decades in the body – but the strategies employed to execute this life-long protection are largely unknown.

New foundation aims for scientific and rhetorical value – and to run the debug cycle for longevity research.

The Longevity Investors Conference is quickly turning into one of the highlights in the longevity calendar, and we were delighted to be able to interview some of the speakers in a few ‘backstage’ moments.

Continue reading “Aubrey de Grey on longevity at scale” »

Dr. Michael Rose is an evolutionary biologist and authority in gerontology. His many years of research and keen insight establish unique methods to frame the problems of aging. Michael made scientific history with experiments manipulating the life spans of fruit flies. As a pragmatist, Michael sees beyond today’s quick fixes to examine what could be the most important changes in the longevity industry to slow down and stop aging. His view is that genomics in conjunction with machine learning is the future of longevity.

The latest trailer for Immortality, a narrative FMV game from Sam Barlow, creator of Her Story. Immortality releases July 26 on Game Pass, Steam, and GOG.

Catch everything that was revealed at the PC Gaming Show: https://www.pcgamer.com/how-to-watch-pc-gaming-show-2022/

Continue reading “Immortality trailer (PC Gaming Show 2022)” »

(https://hannalabweb.weizmann.ac.il/) is a Senior Scientist and Professor in the Department of Molecular Genetics at the Weizmann Institute of Science in Israel, where his lab, and the interdisciplinary group of scientists within it, are focused on understanding the complexity of early embryonic stem cell biology and early developmental dynamics, as well as advancing human disease modeling.

More specifically, Dr. Hanna’s lab investigates the detailed process of cellular reprogramming, in which induced pluripotent stem cells are generated from somatic cells, and they investigate how pluripotency is maintained throughout development in mouse and human. In their studies they employ a diverse arsenal of biological experimentation methods, high throughput screening, advanced microscopy and genomic analyses seeking to combine biological experimentation with computational biology, theory and modeling, to elucidate various biological questions.

Continue reading “Dr. Jacob Hanna, MD, Ph.D. — Synthetic Embryo R&D In Regenerative Medicine & Developmental Biology” »

Mount Sinai researchers have cataloged thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease.

In a study published in Cell Reports, the team described how the rate of RNA editing in the brain increases as individuals age, with implications for dissecting the pathology of altered A-to-I editing across a range of neurodevelopmental and aging disorders.

“Our work provides more nuanced and accurate insights into the contribution of RNA modifications by A-to-I editing during human brain development,” says senior author Michael Breen, Ph.D., Assistant Professor of Psychiatry, and Genetics and Genomic Sciences, at the Icahn School of Medicine at Mount Sinai, and a member of the Seaver Center for Autism Research and Treatment.

Researchers from North Carolina State University have developed a new method for determining which genes are relevant to the aging process. The work was done in an animal species widely used as a model for genetic and biological research, but the finding has broader applications for research into the genetics of aging.

“There are a lot of genes out there that we still don’t know what they do, particularly in regard to aging,” says Adriana San Miguel, corresponding author of a paper on the work and an assistant professor of chemical and biomolecular engineering at NC State.

That’s because this field faces a very specific technical challenge: by the time you know whether an organism is going to live for a long time, it’s old and no longer able to reproduce. But the techniques we use to study genes require us to work with animals that are capable of reproducing, so we can study the role of specific genes in subsequent generations.

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Continue reading “Dietary Fiber And SCFAs Are Relatively Higher in Centenarians-A Pathway To Longevity?” »

Do you want to live a better, healthier and longer life? Me too.

Lets go back to 1937, when Albert Szent-Györgyi won a Nobel Prize for his discovery of ascorbic acid—vitamin C—that enables the body to efficiently use carbohydrates, fats, and protein (I use it a lot during cold and flu season, you?). It was a massively consequential discovery, as it not only saved and extended countless lives, but it also contributed to the foundations of modern nutrition. Szent-Györgyi, himself, was blessed with a long life; he died in 1986 at the age of 93. But he might just as well be known for what he said on his 90th birthday: “I wish I could be 75 again!”

No doubt, that comment elicits more than a few eyerolls today. Especially since the CDC has recently downgraded American life expectancy to just 77 years. But could 75 someday be the new 40—an age by which, like Szent-Györgyi, we’re only hitting our stride? Well, if the burgeoning activity of the life extension industry is any indication, we may actually be on the cusp of making it so—and enjoying life to the fullest right up to the extended end. Which brings us to the morbid thought of mortality—that end state most of us seek to delay, if not dodge.