Lifeboat Foundation

A team of Canadian researchers from Université de Montréal has designed and validated a new class of drug transporters made of DNA that are 20,000 times smaller than a human hair and that could improve how cancers and other diseases are treated.

Reported in a new study in Nature Communications, these molecular transporters can be chemically programmed to deliver optimal concentration of drugs, making them more efficient than current methods.

Researchers from North Carolina State University have developed a new method for determining which genes are relevant to the aging process. The work was done in an animal species widely used as a model for genetic and biological research, but the finding has broader applications for research into the genetics of aging.

“There are a lot of genes out there that we still don’t know what they do, particularly in regard to aging,” says Adriana San Miguel, corresponding author of a paper on the work and an assistant professor of chemical and biomolecular engineering at NC State.

That’s because this field faces a very specific technical challenge: by the time you know whether an organism is going to live for a long time, it’s old and no longer able to reproduce. But the techniques we use to study genes require us to work with animals that are capable of reproducing, so we can study the role of specific genes in subsequent generations.

Scientists from the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL) and Lawrence Berkeley National Laboratory (Berkeley Lab) are providing researchers with a guide to how to best measure the efficiency of producing hydrogen directly from solar power.

Photoelectrochemical (PEC) water-splitting, which relies on sunlight to split water into its component elements—oxygen and hydrogen—stands out as potentially one of the most sustainable routes to clean energy. Measurements of how efficient the PEC process is on an identical system can vary wildly from different laboratories, however, from a lack of standardized methods. The newly developed best-practices guide published in Frontiers in Energy Research is intended to provide confidence in comparing results obtained at different sites and by different groups.

The publication provides a road map for the PEC community as researchers continue to refine the technology. These best practices were verified by both laboratories via round-robin testing using the same testing hardware, PEC photoelectrodes, and measurement procedures. Research into photovoltaics has allowed a certification of cell efficiencies, but PEC water-splitting efficiency measurements do not yet have a widely accepted protocol.

There’s an age-old adage in biology: structure determines function. In order to understand the function of the myriad proteins that perform vital jobs in a healthy body—or malfunction in a diseased one—scientists have to first determine these proteins’ molecular structure. But this is no easy feat: protein molecules consist of long, twisty chains of up to thousands of amino acids, chemical compounds that can interact with one another in many ways to take on an enormous number of possible three-dimensional shapes. Figuring out a single protein’s structure, or solving the protein-folding problem, can take years of finicky experiments.

But earlier this year an artificial intelligence program called AlphaFold, developed by the Google-owned company DeepMind, predicted the 3D structures of almost every known protein —about 200 million in all. DeepMind CEO Demis Hassabis and senior staff research scientist John Jumper were jointly awarded this year’s $3-million Breakthrough Prize in Life Sciences for the achievement, which opens the door for applications that range from expanding our understanding of basic molecular biology to accelerating drug development.

DeepMind developed AlphaFold soon after its AlphaGo AI made headlines in 2016 by beating world Go champion Lee Sedol at the game. But the goal was always to develop AI that could tackle important problems in science, Hassabis says. DeepMind has made the structures of proteins from nearly every species for which amino acid sequences exist freely available in a public database.

Matthew Cobb is a zoologist and author whose background is in insect genetics and the history of science. Over the past decade or so, as CRISPR was discovered and applied to genetic remodeling, he started to get concerned—afraid, actually—about three potential applications of the technology. He’s in good company: Jennifer Doudna, who won the Nobel Prize in Chemistry in 2020 for discovering and harnessing CRISPR, is afraid of the same things. So he decided to delve into these topics, and As Gods: A Moral History of the Genetic Age is the result.

Summing up fears

The first of his worries is the notion of introducing heritable mutations into the human genome. He Jianqui did this to three human female embryos in China in 2018, so the three girls with the engineered mutations that they will pass on to their kids (if they’re allowed to have any) are about four now. Their identities are classified for their protection, but presumably their health is being monitored, and the poor girls have probably already been poked and prodded incessantly by every type of medical specialist there is.

A team of researchers from the National University of Singapore (NUS) have made a serendipitous scientific discovery that could potentially revolutionize the way water is broken down to release hydrogen gas—an element crucial to many industrial processes.

The team, led by Associate Professor Xue Jun Min, Dr. Wang Xiaopeng and Dr. Vincent Lee Wee Siang from the Department of Materials Science and Engineering under the NUS College of Design and Engineering (NUS CDE), found that light can trigger a new mechanism in a catalytic material used extensively in water electrolysis, where water is broken down into hydrogen and oxygen. The result is a more energy-efficient method of obtaining hydrogen.

This breakthrough was achieved in collaboration with Dr. Xi Shibo from the Institute of Sustainability for Chemicals, Energy and Environment under the Agency for Science, Technology and Research (A*STAR); Dr. Yu Zhigen from the Institute of High Performance Computing under A*STAR; and Dr. Wang Hao from the Department of Mechanical Engineering under the NUS CDE.

Ice buildup on powerlines and electric towers brought the northern US and southern Canada to a standstill during the Great Ice Storm of 1998, leaving many in the cold and dark for days and even weeks. Whether it is on wind turbines, electric towers, drones, or airplane wings, dealing with ice buildup typically depends on techniques that are time consuming, costly and/or use a lot of energy, along with various chemicals. But, by looking to nature, McGill researchers believe that they have found a promising new way of dealing with the problem. Their inspiration came from the wings of Gentoo penguins who swim in the ice-cold waters of the south polar region, with pelts that remain ice-free even when the outer surface temperature is well below freezing.

We initially explored the qualities of the lotus leaf, which is very good at shedding water but proved less effective at shedding ice,” said Anne Kietzig, who has been looking for a solution for close to a decade. She is an associate professor in Chemical Engineering at McGill and the director of the Biomimetic Surface Engineering Laboratory. “It was only when we started investigating the qualities of penguin feathers that we discovered a material found in nature that was able to shed both water and ice.”

A group of scientists led by the U.S. Department of Energy’s National Renewable Energy Laboratory (NREL) in Golden and involving the University of Colorado Boulder has developed a new, eco-friendly method to produce ammonia, the main ingredient of fertilizer, using light.

The researchers discovered that light energy can be used to change dinitrogen (N2), a molecule made of two nitrogen atoms, to ammonia (NH3), a compound of nitrogen and hydrogen. The researchers hope the newly discovered, light-driven chemical process that creates ammonia can lead to future developments that will enhance global agricultural practices while decreasing the dependence of farmers on fossil fuels.

Traditionally there have been two main ways to transform nitrogen, the most common gas in Earth’s atmosphere, for use by living organisms. One is a biological process that occurs when atmospheric nitrogen is “fixed” by bacteria found in the roots of some plants like legumes and then converted to ammonia by an enzyme called nitrogenase.

“By now it has become a common futurist prediction and science fiction plot device that intelligent and sentient life forms can be created which are not biochemical in nature and are thus fundamentally different from all currently known life,” distinguished Princeton astrophysicist Edwin Turner wrote in an email to The Daily Galaxy. “Whether or not this would actually be possible,” he explains, “depends on the nature and origin of consciousness, a topic about which we have little more than entertaining whistling-in-the-dark guesses at this point and no clear path toward obtaining any better understanding of this deep mystery.”

Aliens Shaped by Natural Selection

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