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Presynapses locally recycle synaptic vesicles to efficiently communicate information. During use and recycling, proteins on the surface of synaptic vesicles break down and become less efficient. In order to maintain efficient presynaptic function and accommodate protein breakdown, new proteins are regularly produced in the soma and trafficked to presynaptic locations where they replace older protein-carrying vesicles. Maintaining a balance of new proteins and older proteins is thus essential for presynaptic maintenance and plasticity. While protein production and turnover have been extensively studied, it is still unclear how older synaptic vesicles are trafficked back to the soma for recycling in order to maintain balance. In the present study, we use a combination of fluorescence microscopy, hippocampal cell cultures, and computational analyses to determine the mechanisms that mediate older synaptic vesicle trafficking back to the soma. We show that synaptic vesicles, which have recently undergone exocytosis, can differentially utilize either the microtubule or the actin cytoskeleton networks. We show that axonally trafficked vesicles traveling with higher speeds utilize the microtubule network and are less likely to be captured by presynapses, while slower vesicles utilize the actin network and are more likely to be captured by presynapses. We also show that retrograde-driven vesicles are less likely to be captured by a neighboring presynapse than anterograde-driven vesicles. We show that the loss of synaptic vesicle with bound molecular motor myosin V is the mechanism that differentiates whether vesicles will utilize the microtubule or actin networks. Finally, we present a theoretical framework of how our experimentally observed retrograde vesicle trafficking bias maintains the balance with previously observed rates of new vesicle trafficking from the soma.

Cytoskeleton-based trafficking mechanics have long been explored because of their essential role in neuronal function and maintenance (Westrum et al., 1983; Okada et al., 1995; Sorra et al., 2006; Perlson and Holzbaur, 2007; Tao-Cheng, 2007; Hirokawa et al., 2009; Staras and Branco, 2010; Tang et al., 2013; Wu et al., 2013; Maeder et al., 2014; Guedes-Dias et al., 2019; Gramlich et al., 2021; Watson et al., 2023). Protein trafficking via cytoskeleton transport is essential for synaptogenesis (Perlson and Holzbaur, 2007; Santos et al., 2009; Klassen et al., 2010; Wu et al., 2013; Guedes-Dias et al., 2019; Guedes-Dias and Holzbaur, 2019; Kurshan and Shen, 2019; Watson et al., 2023) and to replace older proteins with newer proteins for efficient function (Cohen et al., 2013; Dörrbaum et al., 2018, 2020; Heo et al., 2018; Truckenbrodt et al., 2018; Jähne et al., 2021; Watson et al., 2023).

Researchers have developed a revolutionary material that can help eliminate microplastics, one of the most pervasive artificial contaminants in nature, from our waterways.

Scientists at the Indian Institute of Science have created a sustainable hydrogel — a polymer-based material that can adapt its structure to its environment even after absorbing water — with a “unique intertwined polymer network” that binds the microplastics and breaks them down using UV light, the institute summarized on its website.

Continue reading “Scientists develop breakthrough gel material that could remove one of the most common pollutants — here’s how it works” »

The lab’s latest AI news is something different, though. Instead of designing a model to master a single game, DeepMind has teamed up with researchers from the University of British Columbia to develop an AI agent capable of playing a whole bunch of totally different games.

Called SIMA (scalable i nstructable m ulti-world a gent), the project also marks a shift from competitive to cooperative play as the AI operates by following human instructions.

But SIMA wasn’t created simply to help sleepy players grind out levels or farm up resources. The researchers instead hope that by better understanding how SIMA learns in these virtual playgrounds, we can make AI agents more cooperative and helpful in the real world.

“There has been extensive talk about how larger trees respond to the effects of climate change,” said Dr. Thomas Murphy. “But these results show we need to factor in the response of young trees as well, especially if they are being envisioned as an integral part of the solution.”

Can climate change be fought using saturated soils, and what impacts would these soils have on newly planted trees? This is what a recent study published in Forest Ecology and Management hopes to address as a team of researchers from the University of Plymouth investigated how various soil saturation levels could influence the survival rates of newly planted trees meant to combat climate change. This study holds the potential to help scientists, conservationists, and legislators better understand the steps that can be taken to combat climate change without causing further harm to the environment.

The study involved planting acorns in four different soils: totally flooded, high saturation, medium saturation, and low saturation, with the water levels being just over eight-and-a-half inches (220 millimeters) beneath the acorns. In the end, the researchers discovered a zero-survivability rate for the totally flooded acorns while finding increased survivability rates for high saturation, medium saturation, and low saturation at 43 percent, 77 percent, and 83 percent, respectively. For the higher saturated acorns, the researchers also found decreased levels of leaf photosynthesis, root: shoot ratio, and decreased chances of late season shoot growth, as well.

Continue reading “The Impact of Soil Saturation on Woodland Creation: Insights from UK Uplands” »

A ‘cage of cages’ is how scientists have described a new type of porous material, unique in its molecular structure, that could be used to trap carbon dioxide and another, more potent greenhouse gas.

Synthesized in the lab by researchers in the UK and China, the material is made in two steps, with reactions assembling triangular prism building blocks into larger, more symmetrical tetrahedral cages – producing the first molecular structure of its kind, the team claims.

The resulting material, with its abundance of polar molecules, attracts and holds greenhouse gasses such as carbon dioxide (CO₂) with strong affinity. It also showed excellent stability in water, which would be critical for its use in capturing carbon in industrial settings, from wet or humid gas streams.

Disruptive innovations in technology, such as humanoid robots and electric vehicles, will lead to significant changes in labor, economy, and society, posing both opportunities and challenges for the future Questions to inspire discussion What are the predictions about the future of electric vehicles? —Tony Seba and hi.

“This study has given us an historical picture of how the emerging modern reef responded to huge environmental stress,” said Dr. Jody Webster.

What events caused the Great Barrier Reef to become what it is today, specifically over the course of the last six to eight thousand years, or just after the last Ice Age? This is what a recent study published in Quaternary Science Reviews hopes to address as a team of international researchers conducted an in-depth scientific analysis on various aspects of the Great Barrier Reef to ascertain the environmental factors that contributed to the Reef’s present conditions. This study holds the potential to help scientists better understand how reefs evolve over time and the environment’s role in their evolution.

For the study, the researchers drilled almost two dozen coral samples and analyzed them using a variety of methods, including computer tomography, scanning electron microscopy, and X-ray diffraction to ascertain yearly growth patterns within the coral samples. In the end, they determined that environmental factors, including increased water temperatures, ocean turbulence, and rising sea levels, led to increased nutrients, which contributed to the growth of the Great Barrier Reef, and is consistent with previous studies.

Continue reading “Historical Perspective: The Dynamic Birth of the Modern Great Barrier Reef” »

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Perovskites are among the most researched topics in materials science. Recently, a research team led by Prof. LOH Kian Ping, Chair Professor of Materials Physics and Chemistry and Global STEM Professor of the Department of Applied Physics of The Hong Kong Polytechnic University (PolyU), Dr Kathy LENG, Assistant Professor of the same department, together with Dr Hwa Seob CHOI, Postdoctoral Research Fellow and the first author of the research paper, has solved an age-old challenge to synthesise all-organic two-dimensional perovskites, extending the field into the exciting realm of materials. This breakthrough opens up a new field of 2D all-organic perovskites, which holds promise for both fundamental science and potential applications.

This research was published in the journal Science (“Molecularly thin, two-dimensional all-organic perovskites”).

Perovskites are named after their structural resemblance to the mineral calcium titanate perovskite, and are well known for their fascinating properties that can be applied in wide-ranging fields such as solar cells, lighting and catalysis. With a fundamental chemical formula of ABX 3, perovskites possess the ability to be finely tuned by adjusting the A and B cations as well as the X anion, paving the way for the development of high-performance materials.