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Nanoelectrodes record thousands of connected mammalian neurons from inside

A nanoelectrode array that can simultaneously obtain intracellular recordings from thousands of connected mammalian neurons in vitro.


How our brain cells, or neurons, use electrical signals to communicate and coordinate for higher brain function is one of the biggest questions in all of science.

For decades, researchers have used electrodes to listen in on and record these signals. The patch clamp electrode, an electrode in a thin glass tube, revolutionized neurobiology in the 1970’s with its ability to penetrate a neuron and to record quiet but telltale signals from inside the cell. But this tool lacks the ability to record a ; it can measure only about 10 cells in parallel.

Now, researchers from Harvard University have developed an electronic that can perform high-sensitivity intracellular recording from thousands of connected simultaneously. This breakthrough allowed them to map synaptic connectivity at an unprecedented level, identifying hundreds of synaptic connections.

Alzheimer’s memory loss reversed by new head device using electromagnetic waves

A new, non-invasive brain stimulation treatment shows promise in enhancing memories and cognitive function in those with Alzheimer’s disease. Transcranial electromagnetic treatment (TEMT) increases functional connectivity within the cingulate cortex. TEMT is also able to penetrate the brain to break up amyloid-beta and tau deposits, slowing the progression of Alzheimer’s disease.

Bullying And The Shaping of The Adolescent Brain

There has been a continuously increasing volume of data which has demonstrated that victimization, the clinical term for bullying, affects hundreds of millions of children and adolescents which can sometimes last for years and even decades. This is seen as a global health challenge by the World Health Organization and the United Nations. However, researchers maintain there is still a limited understanding of how this act can affect the developing brain physically.

Most of the research into the neurobiological processes that might contribute to these negative health outcomes has occurred in the past decade, much of it focused on bullying’s impact on the body’s stress response system. A paper published last December in the journal Molecular Psychiatry sheds some light on a different area: brain architecture. The trauma stemming from chronic bullying can affect the structure of the brain, according to longitudinal magnetic resonance imaging (MRI) data collected by an international team based at King’s College London. The findings echo previous research, which has demonstrated similar changes in children and adults who experienced what’s known as “child maltreatment” — neglect or abuse by adult caregivers.

Long-term changes to the brain’s structure and chemistry are an indicator “of how sinister bullying is” says Tracy Vaillancourt, a developmental psychologist at the University of Ottawa. Along with others in the field, she is hopeful that studies like the one from King’s College will be a catalyst for further research which could ultimately be used to inform policy decisions and support anti-bullying interventions.