Lifeboat Foundation

For the first time, scientists identify individual brain cells linked to the linguistic essence of a word.

We identified five themes centred on the impact of diagnosis: (i) Denial and acceptance (three sub-themes: Denial of diagnosis; Acceptance of diagnosis; Conflict between denial and acceptance); (ii) Stigma of diagnosis and selective disclosure; (iii) The process of diagnosis, (iv) Losing, maintaining, and finding a sense of the self (two sub-themes: The lost self; Constructing and maintaining a sense of self); and (v) Receiving, finding, and providing support.

Figure 1 shows a created a diagram on the potential connections between the themes and subthemes. The process of diagnosis spans the entire experience and has a bearing on denial, conflict and acceptance. Stigma also feeds into denial, conflict and lack of identity. Acceptance of a diagnosis is heavily based on the experience and process of healthcare services, and through supportive peer spaces that reinforce and maintains a clear sense of self/identity.

Objective: Cognitive loss in older adults is a growing issue in our society, and there is a need to develop inexpensive, simple, effective in-home treatments. This study was conducted to explore the use of olfactory enrichment at night to improve cognitive ability in healthy older adults.

Methods: Male and female older adults (N = 43), age 60–85, were enrolled in the study and randomly assigned to an Olfactory Enriched or Control group. Individuals in the enriched group were exposed to 7 different odorants a week, one per night, for 2 h, using an odorant diffuser. Individuals in the control group had the same experience with de minimis amounts of odorant. Neuropsychological assessments and fMRI scans were administered at the beginning of the study and after 6 months.

Results: A statistically significant 226% improvement was observed in the enriched group compared to the control group on the Rey Auditory Verbal Learning Test and improved functioning was observed in the left uncinate fasciculus, as assessed by mean diffusivity.

Why is Facebook (Meta) harassing my account?

Decision on case of ex-Facebook moderator, who claims the work left him with PTSD, hailed as win for accountability of big tech in Africa.

In this study we show that residual muscle–tendon afferents enable a person with transtibial amputation to directly neuromodulate biomimetic locomotion, enabling neuroprosthetic adaptations to varying walking speeds, terrains and perturbations. Such versatile and biomimetic gait has not been attainable in contemporary bionic legs without the reliance upon predefined intrinsic control frameworks^1,2. Central to the improved neural controllability demonstrated in this study are muscle–tendon sensory organs^26,27 that deliver proprioceptive afferents. The surgically reconstructed, agonist–antagonist muscles emulate natural agonistic contraction and antagonistic stretch, thereby generating proprioceptive afferents corresponding to residual muscle movements.

During the ground contact phase of walking, the reconstructed muscle–tendon dynamics of the AMI do not precisely emulate intact biological muscle dynamics. The residual muscles of the AMI contract and stretch freely within the amputated residuum, only pulling against one another and not against the external environment. In distinction, for intact biological limbs, the muscle–tendons span the ankle joint, exerting large forces through an interaction with the external environment. These interactive muscle–tendon dynamics in intact biological limbs are believed to play a critical role in spinal reflexes, in addition to providing feedback for volitional motor control¹². Therefore, for this study, the demonstrated capacity of augmented afferents to enable biomimetic gait neuromodulation is surprising given that their total magnitude is largely reduced compared with those of intact biological limbs^26,27,45,46.

Neurological disorders, such as trauma, stroke, epilepsy, and various neurodegenerative diseases, often lead to the permanent loss of neurons, causing significant impairments in brain function. Current treatment options are limited, primarily due to the challenge of replacing lost neurons.

Direct neuronal reprogramming, a complex procedure that involves changing the function of one type of cell into another, offers a promising strategy.

In cell culture and in living organisms, glial cells—the non-neuronal cells in the central nervous system—have been successfully transformed into functional neurons. However, the processes involved in this reprogramming are complex and require further understanding. This complexity presents a challenge, but also a motivation, for researchers in the field of neuroscience and regenerative medicine.

The results of this study link volume loss of hippocampal output structures, and in particular the subiculum, to functional cognitive impairment and to amyloid and tau copathologies in Lewy body diseases:

Background and Objectives.

Hydrogel boosts motor function:

Hydrogel made with hyaluronic acid-graft-dopamine and a designer peptide improved motor function in animals after spinal cord injury.

A study published in the journal Nature Human Behaviour challenges the belief that identical physical actions are governed by the same motor memory, regardless of the decision-making process involved. Researchers from the National Institute of Information and Communications Technology (NICT) and HONDA R&D Co., Ltd. have discovered that the brain differentiates and stores motor memories based on the level of uncertainty experienced during decision-making.

In a football (soccer) penalty shootout, a player may decide to confidently kick the ball to the right corner upon observing the goalkeeper moving in the opposite direction. Alternatively, the player might make the same kick while being unsure about the goalkeeper’s movement.

Although the physical action—kicking the ball to the right—is identical in both scenarios, this new study reveals that the brain tags these actions differently based on the decision uncertainty involved. This discovery suggests that motor memories are not simply repetitions of the same action but are influenced by the cognitive processes leading up to them.