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Archive for the ‘nanotechnology’ category: Page 21

Feb 24, 2024

Genetically engineered T cells for cancer immunotherapy

Posted by in categories: biotech/medical, chemistry, computing, genetics, nanotechnology

Relying on sub-wavelength nanostructures, metasurfaces have been shown as promising candidates for replacing conventional free-space optical components by arbitrarily manipulating the amplitude, phase, and polarization of optical wavefronts in certain applications1,2,3. In recent years, the scope of their applications has been expanded towards complete spatio-temporal control through the introduction of active metasurfaces. These developments open up exciting new possibilities for dynamic holography4, faster spatial light modulators5, and fast optical beam steering for LiDAR6. Large efforts have been channeled into various modulation mechanisms7. Microelectromechanical and nanoelectromechanical systems (MEMS and NEMS)8,9,10,11 have the advantages of low-cost and CMOS-compatibility, but the speed is limited up to MHz. Phase-change materials12,13,14 have fast, drastic, and non-volatile refractive index change, but lack continuous refractive index tuning and have a limited number of cycles constraining applicability to reconfigurable devices. Through molecule reorientation, liquid crystal can have index modulation over 10%, while under relatively low applied voltages Tunable liquid crystal metasurfaces, U.S. patent number 10,665,953 [Application Number 16/505,687]15. Techniques of liquid crystal integration have also advanced after decades of development. However, the tuning speeds are limited to kHz range16. Thermal-optic effects can induce relatively large refractive index changes17,18, but the speed is inherently limited and the on-chip thermal management can be challenging. The co-integration of transparent conductive oxide and metallic plasmonic structures5,6 has been demonstrated in epsilon-near-zero (ENZ) regime to control the wavefront of reflected light, but the low reflection amplitude induced by the optical loss of the materials and the ENZ regime is unavoidable.

In modern photonics, a multitude of technologies for tunable optics and frequency conversion19,20 are realized with nonlinear materials that have low loss and a strong χ effect, such as lithium niobate21,22, aluminum nitride23, and organic electro-optic (OEO) materials24. Their ultrafast responses make it possible to use RF or millimeter-wave control25. Developments in computational chemistry have also led to artificially engineered organic molecules that have record-high nonlinear coefficients with long-term and high-temperature stability26,27. However, their potential in modifying free-space light has been relatively unexplored until recently. Several OEO material-hybrid designs have demonstrated improved tunability of metasurfaces28,29,30. Utilizing dielectric resonant structures and RF-compatible coplanar waveguides, a free-space silicon-organic modulator has recently accomplished GHz modulation speed31. However, all demonstrations to date require high operating voltages ± 60V, due to low resonance tuning capability (frequency shift / voltage), which hinders their integration with electronic chips.

In this work, we propose combining high-Q metasurfaces based on slot-mode resonances with the unique nano-fabrication techniques enabled by OEO materials, which drastically reduces the operating voltage. The low voltage is mainly achieved from the ability to place the electrodes in close proximity to each other while hosting high-Q modes in between and the large overlap of the optical and RF fields in OEO materials. In the following sections, we first provide the design concepts and considerations for achieving a reduced operating voltage. Next, we numerically demonstrate the advantage of a particular selected mode compared to other supported modes in the structure. Finally, we experimentally realize our concepts and characterize the performance of the electro-optic metasurface.

Feb 23, 2024

Dynamic light manipulation via silicon-organic slot metasurfaces

Posted by in categories: chemistry, computing, nanotechnology

Relying on sub-wavelength nanostructures, metasurfaces have been shown as promising candidates for replacing conventional free-space optical components by arbitrarily manipulating the amplitude, phase, and polarization of optical wavefronts in certain applications1,2,3. In recent years, the scope of their applications has been expanded towards complete spatio-temporal control through the introduction of active metasurfaces. These developments open up exciting new possibilities for dynamic holography4, faster spatial light modulators5, and fast optical beam steering for LiDAR6. Large efforts have been channeled into various modulation mechanisms7. Microelectromechanical and nanoelectromechanical systems (MEMS and NEMS)8,9,10,11 have the advantages of low-cost and CMOS-compatibility, but the speed is limited up to MHz. Phase-change materials12,13,14 have fast, drastic, and non-volatile refractive index change, but lack continuous refractive index tuning and have a limited number of cycles constraining applicability to reconfigurable devices. Through molecule reorientation, liquid crystal can have index modulation over 10%, while under relatively low applied voltages Tunable liquid crystal metasurfaces, U.S. patent number 10,665,953 [Application Number 16/505,687]15. Techniques of liquid crystal integration have also advanced after decades of development. However, the tuning speeds are limited to kHz range16. Thermal-optic effects can induce relatively large refractive index changes17,18, but the speed is inherently limited and the on-chip thermal management can be challenging. The co-integration of transparent conductive oxide and metallic plasmonic structures5,6 has been demonstrated in epsilon-near-zero (ENZ) regime to control the wavefront of reflected light, but the low reflection amplitude induced by the optical loss of the materials and the ENZ regime is unavoidable.

In modern photonics, a multitude of technologies for tunable optics and frequency conversion19,20 are realized with nonlinear materials that have low loss and a strong χ effect, such as lithium niobate21,22, aluminum nitride23, and organic electro-optic (OEO) materials24. Their ultrafast responses make it possible to use RF or millimeter-wave control25. Developments in computational chemistry have also led to artificially engineered organic molecules that have record-high nonlinear coefficients with long-term and high-temperature stability26,27. However, their potential in modifying free-space light has been relatively unexplored until recently. Several OEO material-hybrid designs have demonstrated improved tunability of metasurfaces28,29,30. Utilizing dielectric resonant structures and RF-compatible coplanar waveguides, a free-space silicon-organic modulator has recently accomplished GHz modulation speed31. However, all demonstrations to date require high operating voltages ± 60V, due to low resonance tuning capability (frequency shift / voltage), which hinders their integration with electronic chips.

In this work, we propose combining high-Q metasurfaces based on slot-mode resonances with the unique nano-fabrication techniques enabled by OEO materials, which drastically reduces the operating voltage. The low voltage is mainly achieved from the ability to place the electrodes in close proximity to each other while hosting high-Q modes in between and the large overlap of the optical and RF fields in OEO materials. In the following sections, we first provide the design concepts and considerations for achieving a reduced operating voltage. Next, we numerically demonstrate the advantage of a particular selected mode compared to other supported modes in the structure. Finally, we experimentally realize our concepts and characterize the performance of the electro-optic metasurface.

Feb 23, 2024

Photon upconversion: Steering light with supercritical coupling

Posted by in categories: energy, nanotechnology, physics

National University of Singapore researchers and their collaborators have unveiled a novel concept termed “supercritical coupling” that enables a several-fold increase in photon upconversion efficiency. This discovery not only challenges existing paradigms, but also opens a new direction in the control of light emission.

Photon upconversion, the process of converting low-energy photons into higher-energy ones, is a crucial technique with broad applications, ranging from super-resolution imaging to advanced photonic devices. Despite considerable progress, the quest for efficient upconversion has faced challenges due to inherent limitations in the irradiance of lanthanide-doped nanoparticles and the critical coupling conditions of optical resonances.

The concept of “supercritical coupling” plays a pivotal role in addressing these challenges. This fundamentally new approach, proposed by a research team led by Professor Liu Xiaogang from the Department of Chemistry, NUS and his collaborator, Dr. Gianluigi Zito from the National Research Council of Italy leverages on the physics of “bound states in the continuum” (BICs).

Feb 23, 2024

“None of Us Expected This” — Scientists Have Discovered 2D Waveguides

Posted by in categories: nanotechnology, particle physics

The U.S. Naval Research Laboratory (NRL), working together with Kansas State University, has announced the discovery of slab waveguides made from the two-dimensional material hexagonal boron nitride. This milestone has been documented in the journal Advanced Materials.

Two-dimensional (2D) materials are a class of materials that can be reduced to the monolayer limit by mechanically peeling the layers apart. The weak interlayer attractions, or van der Waals attraction, allows the layers to be separated via the so-called “Scotch tape” method. The most famous 2D material, graphene, is a semimetallic material consisting of a single layer of carbon atoms. Recently, other 2D materials including semiconducting transition metal dichalcogenides (TMDs) and insulating hexagonal boron nitride (hBN) have also garnered attention. When reduced near the monolayer limit, 2D materials have unique nanoscale properties that are appealing for creating atomically thin electronic and optical devices.

Feb 22, 2024

Angle-dependent holograms made possible by metasurfaces

Posted by in categories: augmented reality, holograms, nanotechnology

Recently, a research team from Pohang University of Science and Technology (POSTECH) has employed metasurfaces to fabricate angle-dependent holograms with multiple functions. This technology allows holograms to display multiple images based on the observer’s viewing angle. The findings were published in Nano Letters.

Objects can appear distinct depending on the viewer’s position, a concept that can be harnessed in to generate cinematic and realistic 3D holograms presenting different images based on the viewing angle. However, the current challenge lies in controlling light dispersion according to the angle, making the application of nano-optics in this context a complex endeavor.

The team addressed this challenge by leveraging metasurfaces, artificial nanostructures capable of precisely manipulating the characteristics of light. These metasurfaces are incredibly thin and lightweight, approximately one-hundredth the thickness of a human hair, making them promising for applications in miniaturized displays such as virtual and augmented reality devices.

Feb 21, 2024

Self-propelling nanobots shrink bladder tumours in mice by 90%

Posted by in categories: bioengineering, biotech/medical, nanotechnology

Imagine an army of self-propelling, radioisotope-covered particles 2,500 to 10,000 times smaller than a speck of dust that, upon injection into the body, search for and attach themselves to cancerous tumours, destroying them. Sounds like science fiction? Not so for mice with bladder cancer.

Researchers in Spain report that nanoparticles containing radioactive iodine and which propel themselves upon reaction with urea have the ability to distinguish cancerous bladder tumours from healthy tissue. These “nanobots” penetrate the tumour’s extracellular matrix and accumulate within it, enabling the radionuclide therapy to reach its precise target. In a study conducted at the Institute for Bioengineering of Catalonia (IBEC) in Barcelona, mice receiving a single dose of this treatment had a 90% reduction in the size of bladder tumours compared with untreated animals.

This novel approach may one day revolutionize the treatment of bladder cancer. Bladder cancer is the tenth most common cancer in the world, with over 600,000 new cases diagnosed in 2022 and more than 220,000 deaths globally, according to the World Health Organization’s Global Cancer Observatory.

Feb 21, 2024

From Sci-Fi to Reality: Scientists Develop Unbreakable, Bendable Optical Sensor

Posted by in categories: nanotechnology, robotics/AI, wearables

Researchers at Osaka University have developed a groundbreaking flexible optical sensor that works even when crumpled. Using carbon nanotube photodetectors and wireless Bluetooth technology, this sensor enables non-invasive analysis and holds promise for advancements in imaging, wearable technology, and soft robotics. Credit: SciTechDaily.com.

Researchers at Osaka University have created a soft, pliable, and wireless optical sensor using carbon nanotubes and organic transistors on an ultra-thin polymer film. This innovation is poised to open new possibilities in imaging technologies and non-destructive analysis techniques.

Recent years have brought remarkable progress in imaging technology, ranging from high-speed optical sensors capable of capturing more than two million frames per second to compact, lensless cameras that can capture images with just a single pixel.

Feb 20, 2024

Treating liver cancer with microrobots piloted by a magnetic field

Posted by in categories: biotech/medical, nanotechnology, robotics/AI

Canadian researchers led by Montreal radiologist Gilles Soulez have developed a novel approach to treat liver tumors using magnet-guided microrobots in an MRI device.

The idea of injecting microscopic robots into the bloodstream to heal the human body is not new. It’s also not science fiction. Guided by an , miniature biocompatible robots, made of magnetizable iron oxide nanoparticles, can theoretically provide in a very targeted manner.

Until now, there has been a technical obstacle: the force of gravity of these microrobots exceeds that of the magnetic force, which limits their guidance when the tumor is located higher than the injection site. While the magnetic field of the MRI is high, the magnetic gradients used for navigation and to generate MRI images are weaker.

Feb 20, 2024

New mechanism enables the electrical control of the magnetization in magnetic nanodevices

Posted by in categories: nanotechnology, physics

The development of innovative magnetic nanodevices is one step closer to reality thanks to the observation by RIKEN physicists of a type of rotation that can be realized in materials consisting of light elements.

The ability to use to turn revolving mechanical parts led to the development of electric motors and caused an explosion in . Now, physicists are trying to do the same thing but on a nanoscale. However, the development of innovative magnetic nanodevices requires the efficient electrical generation of rotation, or torque.

Usually, torque is generated in by converting electric charge to spin by using the strong spin–orbit interaction of a heavy-metal . The resulting spin current is then injected into adjacent ferromagnetic layers. But heavy-element materials are often incompatible with scalable production processes, and their high resistance makes them unsuitable for some applications.

Feb 20, 2024

A Sprinkle of Gold Dust Could Help Reverse Symptoms of Parkinson’s Disease

Posted by in categories: biotech/medical, nanotechnology, neuroscience

Scientists are investigating whether an oral drug sprinkled with gold nanoparticles could one day treat neurodegenerative diseases like Parkinson’s and multiple sclerosis.

The experimental medicine, called CNM-Au8, has now shown success in boosting the brain’s metabolism in phase II clinical trials.

Research on the safety and efficacy of the daily drug is still ongoing, but the initial results have researchers hopeful. The medicine contains suspended nanoparticles of gold that can apparently pass the blood-brain barrier and improve energy supply to neurons, preventing their decline.

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