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‘Inkable’ nanomaterial promises big benefits for bendable electronics

An international team of scientists is developing an inkable nanomaterial that they say could one day become a spray-on electronic component for ultra-thin, lightweight and bendable displays and devices.

The material, , could be incorporated into many components of future technologies including mobile phones and computers, thanks to its versatility and recent advances in nanotechnology, according to the team.

RMIT University’s Associate Professor Enrico Della Gaspera and Dr. Joel van Embden led a team of global experts to review production strategies, capabilities and potential applications of zinc oxide nanocrystals in the journal Chemical Reviews.

Nanotechnology could be used to treat lymphedema

The human body is made up of thousands of tiny lymphatic vessels that ferry white blood cells and proteins around the body, like a superhighway of the immune system. It’s remarkably efficient, but if damaged from injury or cancer treatment, the whole system starts to fail. The resulting fluid retention and swelling, called lymphedema, isn’t just uncomfortable—it’s also irreversible.

When fail, typically their ability to pump out the fluid is compromised. Georgia Institute of Technology researchers have developed a new treatment using nanoparticles that can repair lymphatic pumping. Traditionally, researchers in the field have tried to regrow lymphatic vessels, but repairing the pumping action is a unique approach.

“With many patients, the challenge is that the lymphatic vessels that still exist in the patient aren’t working. So it’s not that you need to grow new vessels that you can think of as tubes, it’s that you need to get the tubes to work, which for lymphatic vessels means to pump,” said Brandon Dixon, a professor in the George W. Woodruff School of Mechanical Engineering. “That’s where our approach is really different. It delivers a drug to help lymphatic vessels pump using a nanoparticle that can drain into the diseased vessels themselves.”

Semiconductor lattice marries electrons and magnetic moments

A model system created by stacking a pair of monolayer semiconductors is giving physicists a simpler way to study confounding quantum behavior, from heavy fermions to exotic quantum phase transitions.

The group’s paper, “Gate-Tunable Heavy Fermions in a Moiré Kondo Lattice,” published March 15 in Nature. The lead author is postdoctoral fellow Wenjin Zhao in the Kavli Institute at Cornell.

The project was led by Kin Fai Mak, professor of physics in the College of Arts and Sciences, and Jie Shan, professor of applied and engineering physics in Cornell Engineering and in A&S, the paper’s co-senior authors. Both researchers are members of the Kavli Institute; they came to Cornell through the provost’s Nanoscale Science and Microsystems Engineering (NEXT Nano) initiative.

New Ultralight Material Is Tougher than Steel and Kevlar

A joint research project’s findings have just been published in the journal Nature Materials from engineers from MIT, Caltech, and ETH Zurich that has yielded a “nano-architectured” material that could prove stronger than Kevlar and steel. This material, once scaled, could provide a means of developed lightweight, protective coverings, blast shields, and other impact-resistance materials and armors for various industries.

The material is less than a width of a human hair, but still able to prevent the tiny, high-speed particles from penetrating it. According to the researchers behind the project, when compared with steel Kevlar, aluminum rother impact-resistant materials of comparable weight, the new nanotech armor outperforms them all.

Electroactive bacterium generates well-defined nanosized metal catalysts with remarkable water-splitting performance

A biological method that produces metal nanoclusters using the electroactive bacterium Geobacter sulfurreducens could provide a cheap and sustainable solution to high-performance catalyst synthesis for various applications such as water splitting.

Metal nanoclusters contain fewer than one hundred atoms and are much smaller than nanoparticles. They have unique electronic properties but also feature numerous active sites available for catalysis on their surface. There are several synthetic methods for making nanoclusters, but most require multiple steps involving and harsh temperature and pressure conditions.

Biological methods are expected to deliver ecofriendly alternatives to conventional chemical synthesis. Yet, to date, they have only led to large nanoparticles in a wide range of sizes. “We found a way to control the size of the nanoclusters,” says Rodrigo Jimenez-Sandoval, a Ph.D. candidate in Pascal Saikaly’s group at KAUST.

Controlling the degree of twist in nanostructured particles for the first time

Micron-sized “bow ties,” self-assembled from nanoparticles, form a variety of different curling shapes that can be precisely controlled, a research team led by the University of Michigan has shown.

The development opens the way for easily producing materials that interact with twisted light, providing new tools for machine vision and producing medicines.

While biology is full of twisted structures like DNA, known as chiral structures, the degree of twist is locked in—trying to change it breaks the structure. Now, researchers can engineer the degree of twist.

Detect, bind and cut: Biomolecular action at the nanoscale

Researchers at Kanazawa University report in ACS Nano how high-speed atomic force microscopy can be used to study the biomolecular mechanisms underlying gene editing.

The DNA of prokaryotes—single-cell organisms, for example bacteria—is known to contain sequences that are derived from DNA fragments of viruses that infected the prokaryote earlier. These sequences, collectively referred to as CRISPR, for “clustered regularly interspaced short palindromic repeats,” play a major role in the antiviral defense system of bacteria, as they enable the recognition and subsequent neutralization of infecting viruses. The latter is done through the enzyme Cas9 (“CRISPR-associated protein 9”), a biomolecule that can locally unwind DNA, check for the existence of the CRISPR sequence and, when found, cut the DNA.

In recent years, CRISPR/Cas9 has emerged as a genome editing tool based on the notion that the Cas9 protein can be activated with artificially created CRISPR-like sequences. Sometimes, however, the wrong target is “caught” by Cas9—when the wrongly identified DNA sequence is too similar to the intended target sequence. It is therefore of crucial importance to fully understand how Cas9 binds to, “interrogates,” and cuts DNA. Mikihiro Shibata from Kanazawa University and colleagues have now succeeded in video-recording the DNA binding and cleaving dynamics of Staphylococcus aureus (a particular bacterium) Cas9 by means of high-speed atomic force microscopy (HS-AFM). Their observations will help to reach a more complete understanding of CRISPR-Cas9 mechanisms.

DNA synthesis technologies to close the gene writing gap

NPL, in collaboration with London Biofoundry and BiologIC Technologies Ltd, have released an analysis on existing and emerging DNA Synthesis technologies in Nature Reviews Chemistry, featuring the work on the front cover.

The study, which was initiated by DSTL, set out to understand the development trajectory of DNA Synthesis as a major industry drive for the UK economy over the next 10 years. The demand for synthetic DNA is growing exponentially. However, our ability to make, or write, DNA lags behind our ability to sequence, or read, it. The study reviewed existing and emerging DNA synthesis technologies developed to close this gene writing gap.

DNA or genes provide a universal tool to engineer and manipulate living systems. Recent progress in DNA synthesis has brought up limitless possibilities in a variety of industry sectors. Engineering biology, therapy and diagnostics, , defense and nanotechnology are all set for unprecedented breakthroughs if DNA can be provided at scale and low cost.