Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: life extension – Page 91

A.I. for longevity and long lived flies.

Kennedy Schaal presents “Using Advanced A.I. and Blockchain Technology to Targey Aging” at the Longevity+DeSci Summit NYC (EARD 2023) hosted by Lifespan.io. Summary ▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀▀ Kennedy Schaal is the founder and CEO of Rejuve Biotech, an AI-driven therapeutics discovery company solving the problems for longevity and age-associated diseases. By using advanced Artificial Intelligence to combine data from the Methuselah Flies with data from people, Rejuve. Bio can shorten the drug discovery pipeline and rapidly develop novel therapeutics to help people live longer. They have two high-impact and novel data sources, as well as unique artificial intelligence technology. First and foremost, they are the sole owner of data from the Methuselah Flies (fruit flies) that have been bred for longevity. Second, because flies have a shorter life cycle, they can be tested for longevity much faster than other animal models. Rejuve Biotech has the unique ability to test multiple interventions and treatment combinations over the course of a fruit fly’s life and in various aspects of its life (e.g., mating, disease resistance). In addition, they also have quick access to Crowdsourced Human Data collected by a partner company, Rejuve Network. Kennedy Schaal is an accomplished biotechnology executive with a strong leadership track record in applied genomic research and Artificial Intelligence at the frontier of longevity science. She is also a multi-published author on the science of longevity and applied genomics trials. Kennedy is also a world-leading expert on genomic selection and breeding for innovative Drosophila Methuselah Flies, which together with applied Artificial Intelligence solve many of today’s pain points in longevity research, with the potential for massive impact on the health and lifespan of people across the planet. Experienced Laboratory Director and Chief Biologist with a demonstrated history of working in the biotechnology industry. Strong research professional skilled in evolutionary biology, genetics, and the study of aging-related diseases.

Read more | >

according to a retrospective cohort study.

Poor vision is associated with risks for falls and fractures, but details about risks associated with specific eye diseases are less clear. In this retrospective U.K. cohort study, researchers identified nearly 600,000 patients (mean age, 74) with cataracts, glaucoma, or age-related macular degeneration (AMD) and compared them with age-and sex-matched control patients who did not have eye diseases. Falls and fractures were tracked for a median of about 4 years. Analyses were adjusted for a wide range of chronic diseases and medications that increase risk for falls.

Compared with controls, patients with eye diseases had significantly higher hazard ratios for falls and fractures: HRs ranged from 1.18 to 1.38 for the three eye-disease groups. The incidence rates for falls per 100,000 person-years were about 1,800 to 2,500 for the three eye-disease groups, compared with 620 to 850 for control groups. For fractures, the corresponding incidence rates for the three eye-disease groups were 970 to 1,290, compared with 380 to 500 for control groups.

The absolute and relative risks for falls and fractures were similar for all 3 eye-disease groups. An unexplained fall, particularly an injurious one, should prompt primary care clinicians to explore visual impairment as a potential cause or contributing factor.

Read more | >

When young, these neurons signal fatty tissues to release energy fueling the brain. With age, the line breaks down. Fat cells can no longer orchestrate their many roles, and neurons struggle to pass information along their networks.

Using genetic and chemical methods, the team found a marker for these neurons—a protein called Ppp1r17 (catchy, I know). Changing the protein’s behavior in aged mice with genetic engineering extended their life span by roughly seven percent. For an average 76-year life span in humans, the increase translates to over five years.

The treatment also altered the mice’s health. Mice love to run, but their vigor plummets with age. Reactivating the neurons in elderly mice revived their motivation, transforming them from couch potatoes into impressive joggers.

Read more | >

Take a deep dive with NFX into the hottest longevity startups, exploring the mindset of the Founders and why they’re on a mission to keep healthy people healthy, to redesigned healthcare that prevents us from falling into disability and disease over time.

Solving this holds incredible financial and societal value — we have only a few decades left.

Follow to learn more on longevity — https://www.nfx.com/library/bio

Read more | >

Those hoping to avoid one of the worst side effects of aging—bone, joint and muscle pain that doesn’t go away—might need to exercise a lot harder and more often than previously believed.

According to a new study, only high levels of activity at least once a week—playing tennis, running, swimming, digging with a spade, or doing hard physical labor as part of your job—appears to help ward off chronic musculoskeletal pain in the long-term.

The study, led by Dr. Nils Niederstrasser at the University of Portsmouth, examined the data of 5,802 people aged 50 or more over ten years.

Read more | >