Lifeboat Foundation

Imagine walking on a treadmill and time is the speed at which the belt moves. As you age, the speed of the belt increases, representing time passing faster and faster as we age. However, what if we could speed up and run faster than the belt? This is widely known as the concept of Longevity Escape Velocity (LEV), which is essentially the idea of outrunning time itself.

Longevity Escape Velocity refers to a future scenario in which medical progress and innovation allows scientists to extend human lifespan at a rate greater than the passage of time. Imagine a world where each passing year not only adds another year to our lives but also enhances our health, vitality, and functional abilities. This concept, popularised by Biomedical gerontologist Dr. Aubrey de Grey, centres around the idea of developing rejuvenation therapies that repair age-related damage at the cellular and molecular levels, with the aim of effectively reversing the aging process.

Organisations such as Dr Aubrey de Grey’s LEV Foundation are playing a huge role in attempting to achieve this extraordinary milestone by striving to speed up the development of life extending therapies and endeavouring to make them accessible to all. It can be argued that they tend to focus on high risk, high reward research that other institutions might overlook due to its experimental nature, however without those that dare to think big, developments in longevity science will not make the strides needed to make a real impact in our future.

It turns out that an amino acid that our body produces may play a huge role in longevity. Here’s what scientists say about taurine.

An injection of a specific blood factor can replicate exercise’s brain benefits, offering potential treatments for age-related cognitive decline.

Pre-clinical trials by University of Queensland scientists have found that an injection of a specific blood factor can replicate the benefits of exercise in the brain.

Dr. Odette Leiter and Dr. Tara Walker from UQ’s Queensland Brain Institute led a team that discovered platelets, the tiny blood cells critical for blood clotting, secrete a protein that rejuvenates neurons in aged mice in a similar way to physical exercise.

How would it feel to control objects with your mind? Or hear colors? Or maybe even live forever? Well, if you want to find out, all you have to do is become a cyborg. How would being part machine affect us? Would it cause a greater divide between the rich and the poor? And is this the next step in human evolution?

Transcript and sources: https://whatifshow.com/what-if-we-become-cyborgs/

Continue reading “What If We Became Cyborgs?” »

Transhumanism — advocates strongly for humans to develop and make widely available sophisticated technologies that enhance human physiology and intellect greatly. In layman’s terms, transhumanists would like for human beings to become cyborgs; cybernetic organisms.

As such, transhumanist concepts feature greatly in science fiction. Cyborgs are commonly seen in all forms of science fiction media…

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This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs that have been damaged by disease, injured by trauma, or worn by time. I include a full spectrum of chemical, gene, and protein-based medicines, cell-based therapies, and biomechanical interventions that achieve that goal.

As part of a trio of stories on advances in stem cell gene therapy, this piece discusses how to alter blood stem cells using mRNA technology. Previous installments describe how the same platform could reinvent how we prepare patients for bone marrow transplants and correct pathogenic DNA.

At present, the only way to cure genetic blood disorders such as sickle cell anemia and thalassemia is to reset the immune system with a stem cell transplantation. Only a fraction of patients elects this procedure, as the process is fraught with significant risks, including toxicity and transplant rejection. A preclinical study published in Science explores a solution that may be less toxic yet equally effective: mRNA technology. The cell culture and mouse model experiments offer a compelling avenue for future research to enhance or replace current stem cell transplantations altogether.

In a groundbreaking endeavor, researchers at the University of Rochester have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse’s lifespan.

Naked mole rats, known for their long lifespans and exceptional resistance to age-related diseases, have long captured the attention of the scientific community. By introducing a specific gene responsible for enhanced cellular repair and protection into mice, the Rochester researchers have opened exciting possibilities for unlocking the secrets of aging and extending human lifespan.

“Our study provides a proof of principle that unique longevity mechanisms that evolved in long-lived mammalian species can be exported to improve the lifespans of other mammals,” says Vera Gorbunova, the Doris Johns Cherry Professor of biology and medicine at Rochester. Gorbunova, along with Andrei Seluanov, a professor of biology, and their colleagues, report in a study published in Nature that they successfully transferred a gene responsible for making high molecular weight hyaluronic acid (HMW-HA) from a naked mole rat to mice. This led to improved health and an approximate 4.4 percent increase in median lifespan for the mice.

I recently just read a post about the “University of Queensland researchers discovered that the protein ATFS-1 aids in cell longevity by balancing new mitochondria creation and repair.”

It reminded me of this:

I recently came across an article about nurturing your mitochondria. One of the benefits to doing this relates to aging — apparently looking after your mitochondria will help counteract much of what we associate with aging, such as declining energy levels.

Continue reading “Cancer, Mitochondria and Healthy Aging?” »