Lifeboat Foundation

A good summary article about the MitoSENS AMA on Reddit Futurology yesterday.

Aubrey de Grey, who should need little introduction here, is cofounder of the SENS Research Foundation, while Matthew O’Connor leads the foundation’s in-house research efforts. O’Connor’s focus is on the allotopic expression of mitochondrial genes, the complicated form of gene therapy needed to copy versions of these genes from the vulnerable mitochondrial genome into the much more secure nuclear genome, but altered in such a way that the resulting proteins can find their way back to the mitochondria where they are needed. Earlier today de Grey and O’Connor stopped by /r/futurology at Reddit to answer questions on this and other SENS rejuvenation research initiatives. One of the many benefits brought by this modern age of near zero cost communication is the way in which the barrier between researchers, supporters, and the public at large has faded to the point of non-existence. Any interested party can in a few minutes find out who is working in any specific areas of interest and reach out with questions or offers of support. Any researcher can find out where the interested parties congregate to talk about their research and join in. That was science fiction just a few decades ago. The world moves at a fast pace.

Once allotopic expression of the thirteen crucial mitochondrial genes involved in oxidative phosphorylation is realized, undergoing this gene therapy will ensure that the accumulation of mitochondrial DNA damage that occurs over the years no longer contributes to degenerative aging as it does today. It will be an actual, working narrowly focused rejuvenation therapy. As an incidental benefit, this technology will also provide cures for a range of inherited mitochondrial diseases. This work has been underway both at the SENS Research Foundation and in allied labs for some years now, and the biotech company Gensight has been founded on success in allotopic expression of the gene ND4. The SENS Research Foundation in-house team recently achieved success for the mitochondrial genes ATP6 and ATP8, and had a paper accepted by a noted journal, which all in all is a great step forward in a field that has proven to be quite challenging.

Continue reading “Aubrey de Grey and Matthew O’Connor of the SENS Research Foundation Answer Questions on Mitochondrial Research at /r/futurology” »

https://www.youtube.com/watch?v=benzXbi4zu4&noredirect=1

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Medical supply transportation is a serious problem in remote regions, where it may take weeks to transport a vaccine where it’s most needed. But a British student has developed a simple device that might help get supplies where they need to go and save millions of lives in the process.

Will Broadway of Loughborough University created the tank as a way to extend the life of fragile medical supplies, like vaccines, samples, and organs.

The device uses a simple ammonia reaction that creates a cooling effect when charged. It can keep vaccines within a stable temperature realm for up to 30 days. While it’s currently designed for vaccines, Broadway next wants to make it transport organs and tissues to people in need.

Continue reading “A Refrigerator Backpack Could Help Transport Vaccines And Organs” »

The human ‘connectome’.

The Aubrey de Grey and Matthew O’Connor SENS AMA on reddit Monday 12th 11am PST.

I am Dr. Aubrey De Grey, biologist, gerontologist PhD and author of the book Ending Aging and Chief Science Officer at the SENS Research Foundation. I am here with researcher Dr. Matthew O’Connor from the MitoSENS project who is an expert on “allotopic expression” of mitochondrial genes. His team has been working on engineering mitochondrial genes to be expressed from the nucleus and targeted to the mitochondia as part of the MitoSENS approach to one of the damages of aging.

Each cell in the body is dependent on the efficient generation of cellular energy by mitochondria to stay alive. Critical to this process are genes encoded within the mitochondrial genome. Over time however, mutations in these genes occur as a result of constant exposure to reactive oxygen species produced by oxidative phosphorylation, the mitochondrial energy generation process. Unlike genes within the nucleus, mitochondria lack an efficient system to repair damaged DNA. This leads to accumulated mutations, resulting in mitochondrial defects and an increase in oxidative stress throughout the body. Closely correlated with this is the observation that organisms which age more slowly also consistently display lower rates of mitochondrial free radical damage. Thus, reversing and/or preventing damage to mitochondrial DNA may be a key factor in slowing the aging process.

Continue reading “Aubrey de Grey & Matthew O’Connor AMA! • /r/Futurology” »

Acciaroli vila italiana, onde um em cada 10 pessoas vivem além de 100 anos.

Depois de passar seis meses na área, pesquisadores da Universidade de Sapineza de Roma e da Escola de Medicina Sandiego encontraram que os idosos da região têm invulgarmente boa circulação sanguínea para a sua idade.

A equipe de pesquisa analisou amostras de sangue de mais de 80 residentes, e descobriu extraordinariamente baixos níveis de adrenomedullin, um hormônio que alarga os vasos sanguíneos.

Continue reading “Scientists ‘find key to longevity’ in Italian village where one in 10 people live beyond 100 years” »

Ray Kurzweil is a futurist, a director of engineering at Google and a co-founder of the Singularity University think tank at NASA Ames Research Center in Mountain View. He is a nonfiction author and creator of several inventions.

Kurzweil met with the Silicon Valley Business Journal to discuss how technology’s exponential progress is rapidly reshaping our future through seismic shifts in information technology and computing power, energy, nanotechnology, robotics, health and longevity.

Biohacking, nootropics, and the notion of optimizing one’s human performance are on a rapid rise. Nootrobox founders Geoffrey Woo and Michael Brandt are some of the foremost thinkers in this space, and they are here to have intellectual conversations that will make you THINK.

Episode 9 features Aubrey de Grey, the Chief Scientist Officer of the SENS Research Foundation. In this episode, Geoff, Michael, and Aubrey discuss the nuances of aging and health and their differing opinions and tactics of how to fully optimize these notions.

Continue reading “THINKING Podcast” »

No shock to me.

Diamandis claimed that we are gearing towards a future possible of “interface mind-machine, where in human brain’s consciousness could be uploaded to computer and then transferred to a new body—probably a cultured in the lab. He estimates that it will just take 20–30 years to be realized.

The reality of extended life longevity to almost immortality is actually not too hard to believe these days. After all science and technology never failed to amuse us to make the once impossible possible.

Continue reading “We Might Be Getting Closer To ‘Immortality’ Through Medical Nanotechnology” »