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Having healthy mitochondria, the organelles that produce energy in all our cells, usually portends a long healthy life whether in humans or in C. elegans, a tiny, short-lived nematode worm often used to study the aging process.

Researchers at the Buck Institute have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms. The compound, dubbed MIC, is a natural compound that extended lifespan in C. elegans, ameliorated pathology in neurodegenerative disease models of C. elegans, and improved mitochondrial function in mouse muscle cells. Results are published in the November 13, 2023, edition of Nature Aging.

Defective mitophagy is implicated in many age-related diseases. It’s tied to neurodegenerative disorders such as Parkinson’s and Alzheimer’s; it plays a role in cardiovascular diseases including heart failure; it influences metabolic disorders including obesity and type 2 diabetes; it is implicated in muscle wasting and sarcopenia and has a complex relationship with cancer progression.

Mitophagy-inducing compound (MIC), a natural compound in plants, may combat age-related diseases by promoting mitochondrial health through mitophagy.

Mohammed Haneefa Nizamudeen / iStock.

According to a statement by scientists, mitophagy is a process that removes and recycles damaged mitochondria in multicellular organisms.

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Continue reading “Conquer Aging or Die Trying Podcast, Episode #1: Crissman Loomis (@Unaging.com)” »

Imagine a skin cream that heals damage occurring throughout the day when your skin is exposed to sunlight or environmental toxins. That’s the potential of a synthetic, biomimetic melanin developed by scientists at Northwestern University.

In a new study, the scientists show that their synthetic melanin, mimicking the natural melanin in human skin, can be applied topically to injured skin, where it accelerates wound healing. These effects occur both in the skin itself and systemically in the body.

When applied in a cream, the synthetic melanin can protect skin from sun exposure and heals skin injured by sun damage or chemical burns, the scientists said. The technology works by scavenging free radicals, which are produced by injured skin such as a sunburn. Left unchecked, free radical activity damages cells and ultimately may result in skin aging and skin cancer.

Bryan Johnson daily routine. Cortesy of Fortune Magazine.

The video was originally included in an article published in Fortune Magazine on March 27, 2023.

Continue reading “Bryan Johnson explaining his daily routine in Fortune Magazine (con S/T en Español)” »

Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden. The discovery could lead to new treatments for a wide array of diseases relating to mitochondrial dysfunction, such as cancer and auto-immune disorders. Mitochondria are organelles that supply most of the chemical energy needed to power cells’ biochemical reactions.

The study is published in the journal PNAS. The researchers analyzed more than 130 proteins released by Coxiella burnetii when this bacterium invades host cells, and found at least one to be capable of prolonging cell longevity by acting directly on mitochondria.

After invading host cells, C. burnetii releases a hitherto unknown protein, which the authors call mitochondrial coxiella effector F (MceF). MceF interacts with glutathione peroxidase 4 (GPX4), an anti-oxidant enzyme located in the mitochondria, to improve mitochondrial function by promoting an anti-oxidizing effect that averts cell damage and death, which may occur when pathogens replicate inside mammalian cells.

Bryan Johnson is the world’s most famous biohacker – and perhaps the “most measured man in human history”. He’s on a mission to maximally reverse the quantified biological age of each of his 70 organs, extending his lifespan and healthspan, and then roll out his protocol on a platform to ensure others can benefit from his experience, research and experimentation.

Johnson’s ethos can be summed up pretty neatly as don’t die, and to that end, he has written a book, or novel, to be more accurate, entitled Don’t Die, the uncorrected advanced reading version of which is downloadable as a free ebook from his website. Johnson’s nom de plume for this venture is Zero, described in the book as the “first individual H. sapiens to surpass five hundred years of age,” who dies in 2,478 (in an accident, rather than from old age), just weeks away from “becoming Homo Deus.” Johnson credits Zero with the invention of Zeroism and the resurrection technology undie, as well as the fathering of “millions of biological and digital offspring who now live in the far reaches of the solar system and beyond”

Longevity. Technology: Because Don’t Die is a novel, Johnson can explore his philosophy in a different way, inviting us to observe the narrator, Scribe, on his last day on Earth, as he muses on humanity’s future evolution, the nature of death and free will and the impact of age reversal and programmable biology. Scribe is joined by a Pilgrim’s Progress-like cast of characters, including Cognitive Bias, Dark Humor and Game Play and Self Critical.

The Rejuvenation Startup Summit (Berlin, May 10–11, 2024) hosted by the Forever Healthy Foundation, is a vibrant networking event that aims to accelerate the development of the rejuvenation biotech industry.

Rejuvenation/longevity biotech is a new, emerging field of medicine. It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself. Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification, tissue stiffening, loss of stem cell function, genetic alterations, and impaired energy production.