Lifeboat Foundation

Senolytic compounds hold promise to reverse aging in humans. Researcher James Kirkland publishes a list of senolytics in a review published yesterday. Two of the senolytics are currently in clinical trials. [Cover photo: Can Senolytic Drugs Reverse Aging? Credit: Getty Images.]

Imagine if you were able to reverse aging and bring your body back to its original health and vigor.

Researchers have already discovered a group of drugs called senolytics which perform this miraculous transformation in mice and are testing them in humans as we speak.

Continue reading “New Senolytic Drugs Reverse Aging — ‘Can Transform Medicine’ Says Leading Researcher” »

UCLA scientists working with middle-aged fruit flies say they were able to improve the insects’ health while markedly slowing down their aging process. The team thinks its technique could eventually help delay the onset of Parkinson’s disease, Alzheimer’s disease, cancer, stroke, cardiovascular disease, and other age-related diseases in humans.

The researchers zeroed in on mitochondria, which often become damaged with age. When cells can’t eliminate the damaged mitochondria, they can become toxic and contribute to a wide range of age-related diseases, said David Walker, Ph.D., a UCLA professor of integrative biology and physiology, and the study’s senior author.

Dr. Walker and his colleagues found that as fruit flies reach middle age—about one month into their two-month lifespan—their mitochondria change from their original small, round shape.

Continue reading “UCLA Team Genetically Manipulates Mitochondria to Extend Fruit Flies’ Lifespan” »

During the recent Longevity and Cryopreservation Summit in Madrid, LEAF board member Paul Spiegel discussed the social ramifications of increased lifespans thanks to emerging technologies. He spoke of the need for society to adapt to deal with longer lives. We invite you to watch the talk he gave and also to read an interview providing deeper insight on the necessary changes in the pension system.

But first, a few words about Paul. Paul graduated cum laude from the University of California, Berkeley in 1979 and from Boalt Hall School of Law in 1983. He has attended Harvard Law School, the University of Paris, Sorbonne, and International Christian University in Tokyo.

Continue reading “Paul Spiegel: Beyond Retirement – A New Social Compact for the Age of Longevity” »

The secret to a long life? A protein that acts as a cellular ‘time machine’ is found to extend the lifespan of fruit flies by 20%.

Biologists have turned back the clock on ageing in the cells of fruit flies, by increasing levels of a protein called Drp1.

Continue reading “Cellular ‘time machine’ could offer Parkinson’s treatment” »

Oxford scientists are collaborating with artificial Intelligence company Insilico Medicine to prevent unnecessary animal sacrifice and derive more data from experiments in age related research.

The MouseAge.org initiative is being managed by UK charity; Biogerontology Research Foundation and will also include researchers from Harvard and Youth Laboratories in the development of tools for cross-species analysis and novel biomarkers of ageing and various diseases in mice.

Insilico Medicine which provides advanced machine learning services to skin care companies, is using the field of ‘omics’ to introduce a broad range of deep-learned biomarkers of ageing and age-related diseases.

Continue reading “Oxford scientists collaborate with A.I firm on ageing related diseases” »

By treating one of the root causes of aging – senescent cells – a new class of drugs, known as senolytics, has the potential to treat a wide range of age-related diseases rather than the traditional approach of dealing with them one at a time. We all age, but the research suggests that we may not have to suffer from age-related ill health.

So what are senescent cells?

As we age, increasing amounts of our cells enter into a state known as senescence. Normally, these cells destroy themselves by a self-destruct process known as apoptosis and are disposed of by the immune system. Unfortunately, as we age, increasing numbers of these cells evade apoptosis and linger in the body.

Unable to accept his own end, he decides to freeze his body. Sixty years later, in the year 2084, he becomes the first cryogenically frozen man to be revived in history. Marc discovers a startling future, but the biggest surprise is that his past has accompanied him in unexpected ways.

In case you’ve missed the news, Lifespan.io has another crowdfunding campaign running right now!

Before I’m too late for the party, I’d like to let you know that Lifespan.io’s crowdfunding campaign AgeMeter for the development of a diagnostic system to measure functional human age has been extended by two weeks. Presently, 70% of the necessary funds have been collected, i.e. a little over 20.000 dollars out of 30.000. It would be great if yet this other campaign made it to its goal, so if you haven’t made your donation yet, please do—remember, there’s no such thing as a donation which is too small: Broadly speaking, as long as the amount you donate is a positive real number, it is much appreciated! The AgeMeter campaign will end on September 16, 2017.

Continue reading “News from Lifespan.io campaigns” »

A new study published by scientists at the Salk Institute recently shows how that changes in the nucleolus of progeria cells and normally aged cells share some characteristics that may allow them to be used as a biomarker for biological age[1].

What is Progeria?

Hutchinson-Gilford progeria is a rare genetic disease that causes people to suffer from aging-like symptoms on an accelerated timescale compared to regular aging. Whilst it shares similarities with regular aging it is not accelerated aging per se, but the outcome is much the same.