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Category: life extension – Page 42

Tracking Plasma Taurine: 13-Test Analysis

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Targeting protein restores aging blood cells, UF researchers find

GAINESVILLE, Fla. — As humans age, we develop chronic inflammation in our blood and tissues that gradually decreases the function of blood stem cells in our bone marrow. These defects harm blood cell production and the immune system, often leading to a slew of complications and weakening responses to chemotherapy.

Now, UF Health Cancer Center researchers have discovered a way to prevent this inflammation, called “inflammaging,” by systemically targeting a protein. The findings in mice, published Jan. 3 in Science Immunology, could pave the way for therapies aimed at preserving an aging blood system, with implications for cancer treatments and aging-related diseases, including anemias, infections, and blood cancers.

“We set out to determine if we could fully preserve and rejuvenate blood stem cell function during the course of aging, a goal that had remained largely elusive so far,” said Jason Butler, Ph.D., a professor and vice chief of research in the UF Division of Hematology and Oncology and a member of the UF Health Cancer Center, who led the new study.

Maintaining Telomeres Extends Lifespan in Mice

A recent study has found that the overexpression of telomerase reverse transcriptase (TERT), which is a subunit of telomerase, an enzyme essential for telomere maintenance, leads to lifespan extension in mice without significant side effects [1].

Protecting DNA

Telomere shortening is a well-known hallmark of aging. Telomeres are protective DNA sequences at the ends of the chromosomes. In most human cells, they become shorter with each division.

How NAD Keeps Your Cells Energized and Slows Down Aging

NAD, a vital molecule for cellular energy and DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Experimental drug speeds up myelin repair, restoring vision in mice

Researchers at the University of Colorado Anschutz Medical Campus have found a promising drug candidate that could help restore vision in individuals with multiple sclerosis (MS) and other neurological conditions that damage neurons.

The study was published this week in the journal Nature Communications.

The drug, LL-341070, enhances the brain’s ability to repair damaged — the protective sheath around nerve fibers. Damage to myelin is a hallmark of diseases like MS, as well as a natural consequence of aging, often resulting in , loss of motor skills, and cognitive decline.

Genetic Evolution: Shaping Our Future Through Engineering

Genetic engineering is a beacon of hope. It promises eternal life, curing diseases and feeding the growing world population. The possibilities are boundless. The invention is not that old. But their pace is rapid. Life without genetic engineering will no longer exist. We are at the beginning of a new evolution.

The Silent Front (Extra Long Documentary) — • The Silent Front: Spies and Secrets o…

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Sam Altman-backed Retro Biosciences to raise $1bn for project to extend human life

LEV is upon us.

OpenAI chief executive Sam Altman, who provided the initial $180mn to seed the start-up, will put in more money in the series A. The company is in talks with family offices, venture capitalists and sovereign wealth funds, as well as a US “hyperscaler” data centre to provide computing power to run the AI models it uses to create and test its treatments.

In partnership with OpenAI, the start-up has built a bespoke AI model that designs proteins to temporarily turn regular cells into stem cells, which it says can reverse their ageing process.

The San Francisco-based biotech will use the money to fund clinical trials for three drugs, including a potential treatment for Alzheimer’s disease, which will be tested in an early stage study in Australia this year. It is also working on drugs for rejuvenating blood and brain cells.

December 2024 Longevity Review

A review of the most interesting and impactful longevity related studies from December, including how gene therapy can increase telomere length and how the immune system can be used to clear senescent cells.

Contents:

1. Intro 0:00
2. Gene Therapy To Increase Telomere Length 0:48
3. Freeing The Immune System To Remove Senescent Cells 15:20
4. Using Probiotics To Help With Sarcopenia 27:39.

Canadian Content Study.
5. Extracellular Vesicles To Combat Neuroinflammation 35:59.

Link to the newsletter being discussed (both online and PDF versions):
/ december-2024–120640668

Links to studies reviewed in this newsletter:

Continue reading “December 2024 Longevity Review” | >

Logging off Life but Living on: How AI Is Redefining Death, Memory, and Immortality

While the idea of a digital afterlife is fascinating, it raises some big questions. For example, who owns your online accounts after you die?

This issue is already being discussed in courts and by governments around the world. In the United States, nearly all states have passed laws allowing people to include digital accounts in their wills.

In Germany, courts ruled that Facebook had to give a deceased person’s family access to their account, saying that digital accounts should be treated as inheritable property, like a bank account or house.

Mutations Drive Aging and Shape Epigenetic Clock

New research shows somatic mutations drive epigenetic changes tied to aging. This discovery reshapes our understanding of aging and challenges current anti-aging strategies.

Summary: A new study has uncovered a direct link between somatic mutations and epigenetic modifications, challenging established views on aging. Researchers found that random genetic mutations drive predictable changes in DNA methylation, offering new insights into the relationship between mutation accumulation and epigenetic clocks.

This suggests that epigenetic changes may track, rather than cause, aging, making it harder to reverse aging than previously thought. These findings redefine our understanding of aging at the molecular level and hold significant implications for future anti-aging therapies.