Famed anti-aging research pioneer David Sinclair took to twitter earlier this week to formally respond to allegations of unethical business practices and government overreach concerning the recent ban of the popular anti-aging supplement, NMN.
https://www.youtube.com/watch?v=QykUAQmSzpU
Slowing speed of aging will increase life expectancy.
Peter Diamandis, the founder of the Singularity University and the X Prize Foundation has a goal for the next decade: to add 20 or 30 healthy years to people’s life. Or, in other words, making 100 years old the new 60s. He presents his vision during “Priorities”, a summit that took place on September 2022 in New York and organized by the FII Institute. Here are the highlights.
Continue reading “Peter Diamandis: In 10 Years Tech Will Reset Your Age” »
Researchers at UC San Francisco (UCSF) have engineered molecules that act like “cellular glue,” allowing them to direct in precise fashion how cells bond with each other. This discovery represents a major step toward building tissues and organs, a long-sought goal of regenerative medicine [1].
Longevity. Technology: Adhesive molecules are found naturally throughout the body, holding its tens of trillions of cells together in highly-organised patterns. They form structures, create neuronal circuits and guide immune cells to their targets. Adhesion also facilitates communication between cells to keep the body functioning as a self-regulating whole.
Now a new study, published in Nature, details how the researchers engineered cells containing customised adhesion molecules that bound with specific partner cells in predictable ways to form complex multicellular ensembles.
Awareness about aging and early symptom of disease can extend life to much more year.
There has been plenty going on here at Lifespan.io, so we thought it was time to give you a little update on what’s been happening.
Continue reading “Raising Awareness that Aging is a Problem Worth Solving” »
LEV Foundation’s flagship research program is a sequence of large mouse lifespan studies, each involving the administration of (various subsets of) at least four interventions that have, individually, shown promise in others’ hands in extending mean and maximum mouse lifespan and healthspan.
We focus on interventions that have shown efficacy when begun only after the mice have reached half their typical life expectancy, and mostly on those that specifically repair some category of accumulating, eventually pathogenic, molecular or cellular damage. The first study in this program is starting in January 2023.
Is digital immortality possible by uploading your mind? Dr. Paul Thagard discusses Neuralink, artificial intelligence, mind uploading, simulation theory, and the challenges involved with whole brain emulation.
Dr. Paul Thagard is a philosopher, cognitive scientist, and author of many interdisciplinary books. He currently teaches as a Distinguished Professor Emeritus of Philosophy at the University of Waterloo, where he founded and directed the Cognitive Science Program.
Continue reading “Paul Thagard — Substrate-Independent Minds” »
In a new review article published in Frontiers in Cell and Developmental Biology, researchers have suggested adding cellular enlargement to the hallmarks of aging [1].
Different cell types are known to have different shapes and sizes, which are dictated by their functions. In humans, sperm cells (male gametes) and ova (female gametes) have the smallest and largest diameters, respectively. On the other hand, some neurons are the longest cells: their axons can be over a meter long.
Nevertheless, within a specific cell type, the size variation is negligible. It has been long observed that healthy cells tend to maintain their size and that size changes are characteristic of pathological conditions. Cancer cells are often smaller than normal cells, while senescence leads to cellular enlargement [2].
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In this video Professor Sebastiano discusses the results that he and his team have had in rejuvenating human cells and how the process could be applied as well as their experience rejuvenating a muscle in an old mouse.
Unity CEO Anirvan Ghosh, Ph.D./courtesy of Unity Biotechnology
Senolytic therapies are, at this point, as revolutionary as checkpoint inhibitors but with broader effectiveness. This approach delays the onset of diseases of aging by removing senescent cells from the body, thus enabling people to remain healthier longer or to regain some degree of function lost to disease.
Senolytics is a new field and most of the research is still in academic centers – most notably, the Mayo Clinic. Approval of any therapeutics is years – perhaps even a decade – away.
During aging, mice, like humans, become inactive and lose muscle mass and strength. A team of scientists led by Johan Auwerx at EPFL have now discovered that when mice age, their muscles become packed with ceramides. Ceramides, known for their use in skin care products, are sphingolipids, a class of fat molecules that are not used to produce energy but rather perform different tasks in the cell.
The researchers found that, in aging, there is an overload of the protein SPT and others, all of which are needed to convert fatty acids and amino acids to ceramides. “The sphingolipids and ceramides are complex yet very interesting fat class, and there is high potential to further study their role in aging, as they perform many diverse functions,” says Dr. Pirkka-Pekka Laurila, a medical doctor and the lead author of the study.
Next, the scientists wanted to see whether reducing ceramide overload could prevent age-related decline in muscle function. They treated old mice with ceramide blockers, such as myriocin and the synthetic blocker Takeda-2, and used adeno-associated viruses to block ceramide synthesis specifically in muscle. The ceramide blockers prevented loss of muscle mass during aging, made the mice stronger, and allowed them to run longer distances while improving their coordination.
