Lifeboat Foundation

Zika. Ebola. Dengue. Influenza. Chikungunya. These are but a few among the growing cadre of viruses that today pose serious health threats to U.S. troops, as well as to civilian populations in the United States and around the world. Vaccines exist for but a few of these infectious diseases. And since these viruses have an uncanny ability to mutate and morph as they reproduce inside their hosts, those few vaccines that do exist are quickly outdated, providing little protection against the latest viral strains. That’s why flu vaccine manufacturers, for example, must produce new versions annually, at enormous expense and with variable year-to-year efficacy.

Ideally, to outpace evolving pathogens, a therapy or a vaccine would adapt in real time, shape-shifting as fast as its targets do. To pursue that radical approach, DARPA today launched its INTERfering and Co-Evolving Prevention and Therapy (INTERCEPT) program.

“We need a new paradigm to stay ahead of these moving targets,” said Jim Gimlett, DARPA program manager. “With INTERCEPT, the goal is to develop viral therapies that are effective against a broad spectrum of viral strains, and that can co-evolve and outpace new strains.”

A common drug could hold the key to long life, in flies at least, according to research.

At low doses, lithium prolonged the life of fruit flies in lab experiments.

Scientists say the finding is “encouraging” and could eventually lead to new drugs to help people live longer and healthier lives.

A new programming language allows scientists to custom-code bacteria that can measure the health of other cells, and administer drugs when necessary.

Very nice goal to have “all things connected” in Toyota’s and Microsoft’s case is “Singularity” lite meaning physical structures are connected; however, bio connection does not exist (only consumer profile information is available and integrated). This could be considered an interim state for Singularity.

The company called Toyota Connected has a goal of simplifying technology so it’s easier to use, perhaps even getting rid of distracting and complicated touch screens that now are in most cars and replacing them with heads-up or voice-activated technology, said Zack Hicks, the company’s CEO who also is Toyota Motor America’s chief information officer. Like other automakers, Toyota Connected will research connecting cars to each other and to homes, as well as telematics features that learn and anticipate a driver’s habits. The company, like other automakers, will explore transmitting a driver’s health data to a doctor or driving patterns to an insurance company so people are insured based on where they travel, Toyota said.

Scientists just got one step closer to understanding the nuts and bolts of how your mind handles emotions. An MIT team has identified two neural connections in the brain’s amygdala regions that process positive and negative emotional events. By tagging neuron groups with a light-sensitive protein, they discovered that the neurons form parallel but complex channels that respond differently to given situations. Some neurons within one of those connection will be excited by a feeling, while others will be inhibited — the combination of those reactions in a given channel may determine the emotion you experience.

It’s still early days. The researchers need to explore specific neuron populations in-depth to see how they’re connected, and they have to clearly define the larger neural circuits. If they succeed, though, they might help explain how mental health issues operate. Anxiety and depression might not fire the neurons that normally go off when you’re happy, for instance. The discoveries could lead to more effective treatments that restore your natural reactions.

Continue reading “Scientists identify neurons that help you process emotions” »

1st of many steps in the gene editing oversight.

PRINCETON, N.J., March 29, 2016 /PRNewswire/ — WIRB-Copernicus Group^® (WCG™), one of the world’s leading providers of solutions that measurably improve the quality and efficiency of clinical research, today announced that it has assembled a team of world-renowned experts to advise the company regarding the latest advances in gene therapy research. The WCG Gene Therapy™ Advisory Board will convene today in Princeton, NJ.

“Human gene therapy is one of the fastest-growing areas of medical research, and also one of the most promising,” said WCG Chairman and Chief Executive Officer Donald A. Deieso, Ph.D. “The advances made by scientists and clinicians in the field of gene therapy have enabled us to target disease at the genetic level, redefining the concept of precision medicine.” He added, “More than that, gene transfer researchers have succeeded – over the course of a single lifetime – in transforming the world’s most persistent and lethal viruses into disease-fighting allies in the quest to improve human health.”

Continue reading “WIRB-Copernicus Group Establishes WCG Gene Therapy Advisory Board” »

New diet craze:

This article explores how low-carb and ketogenic diets affect the brain.

What Are Low-Carb and Ketogenic Diets?

Continue reading “What Is a Ketogenic Diet and Can It Really Boost Brain Health?” »

Hmmm;

Researchers are testing mild electrical stimulation to improve brain function and mental health, but warn do-it-yourselfers to be wary of treating themselves with models available online.

Dr. Fidel Vila-Rodriguez, director of the Non-Invasive Neurostimulation Therapies (NINET) Lab at the University of B.C., is starting to lend devices for home use to people with Parkinson’s disease and depression that will deliver a weak electrical current through electrodes placed on their temples.

Continue reading “Experts wary of electrical brain stimulation at home” »

Despite all our advances in cancer research, our best strategy of fighting the disease is still brute force, with only a fraction of the drugs administered actually reaching the tumour cells, and most being absorbed into healthy tissue. When cancer spreads, the likelihood of medication reaching it gets even lower, which is why secondary, or metastatic, tumours can be so deadly.

But now, researchers have used cancer’s own tricks against it, by developing dissolvable nanoparticles that target the heart of metastatic tumours directly. And they’ve already seen unprecedented success in mouse studies, with 40–50 percent of the animals being “functionally cured”, and tumour-free after eight months — the equivalent of about 24 years for a human patient. The team is so excited by these results, they hope to fast-track the research and begin human trails in 2017.

“I would never want to overpromise to the thousands of cancer patients looking for a cure, but the data is astounding,” said one of the researchers, Mauro Ferrari, from the Houston Methodist Research Institute. “We’re talking about changing the landscape of curing metastatic disease, so it’s no longer a death sentence.”

Continue reading “Silicon ‘nano-balls’ have wiped out metastatic breast cancer in mice” »