Lifeboat Foundation

The visible impacts of depression and stress that can be seen in a person’s face—and contribute to shorter lives—can also be found in alterations in genetic activity, according to newly published research.

In a series of studies involving both C. elegans worms and human cohorts, researchers from the Indiana University School of Medicine and the Scripps Research Institute have identified a series of genes that may modulate the effects of good or bad mood and response to stress on lifespan. In particular, the research pointed to a gene known as ANK3 as playing a key role in affecting longevity. The research was published May 24, 2016 in the Nature Publishing Group journal Molecular Psychiatry, the top ranked journal in the field of psychiatry.

“We were looking for genes that might be at the interface between mood, stress and longevity”, said Alexander B. Niculescu III, M.D., Ph.D., professor of psychiatry and medical neuroscience at the IU School of Medicine. “We have found a series of genes involved in mood disorders and stress disorders which also seem to be involved in longevity.

Continue reading “Researchers identify genes linked to the effects of mood and stress on longevity” »

(Medical Xpress)—A large team of researchers from a host of research facilities across Japan has found some genetic variants in some cancer cells that lead to enhanced PD-L1 protein production—which results in increased protection against attacks by the immune system. In their paper published in the journal Nature, the team describes their sequencing study involving adult T-cell leukemia/lymphoma cases, what they found and the possibility that such variants could be used as identifying markers in cancer patients.

Prior studies have shown that an increase in the expression of the protein PD-L1 by cancer cells confers enhanced protection against attacks by the human immune system—PD-1 receptors on T cells bind with PD-L1 causing the immune cells to become unresponsive, preventing them from attacking tumors. In this new effort, the researchers conducted a genetic analysis of a particular type of cancer cell to learn more about the genetic process involved in causing an increase in expression of PD-L1.

The team conducted whole-genome sequencing on samples given by 49 adult patients suffering from leukemia or lymphoma, looking specifically for variations that might account for an increase in expression of PD-L1. In so doing, they found that variations such as duplications, inversions or translocations in 13 of the samples, representing 27 percent of those tested, existed on a certain part of chromosome 9, which prior research had found was the part of the genome responsible for the expression of PD-L1. They report that such alterations seemed to cut off the gene’s 3’ untranslated region of the protein and in some cases led to rearranging the gene’s open reading frame, which allowed more of the protein to be expressed.

Continue reading “Genetic variants isolated that lead to enhanced PD-L1 protein production in cancer cells” »

“The possibility to selectively activate genes using various engineered variants of the CRISPR-Cas9 system left many researchers questioning which of the available synthetic activating Cas9 proteins to use for their purposes. The main challenge was that all had been uniquely designed and tested in different settings; there was no side-by-side comparison of their relative potentials,” said George Church, Ph.D., who is Core Faculty Member at the Wyss Institute for Biologically Inspired Engineering at Harvard University, leader of its Synthetic Biology Platform, and Professor of Genetics at Harvard Medical School. “We wanted to provide that side-by-side comparison to the biomedical research community.”

In a study published on 23 May in Nature Methods, the Wyss Institute team reports how it rigorously compared and ranked the most commonly used artificial Cas9 activators in different cell types from organisms including humans, mice and flies. The findings provide a valuable guide to researchers, allowing them to streamline their endeavors.

The team also included Wyss Core Faculty Member James Collins, Ph.D., who also is the Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at the Massachusetts Institute of Technology (MIT)’s Department of Biological Engineering and Norbert Perrimon, Ph.D., a Professor of Genetics at Harvard Medical School.

Continue reading “A Guide to CRISPR Gene Activation” »

Harvard you’re wrong. Why? Harvard needs to explain to all the families with genetic mutations tied to various types of cancer, cancer survivors who carry a genetic mutation, or the workers who were exposed at work to radiation or carcinogens how their smoking caused their cancer when they never smoked in their entire life. However, how do you explain that to the countless million patients, survivors, and loved ones who lost someone to cancer that never smoked or were exposed to smoking.

As many as 40 percent of cancer cases, and half of cancer deaths, come down to things people could easily change, researchers said Thursday.

While Americans often worry about whether chemicals, pollution or other factors out of their control cause cancer, the new analysis shows otherwise: People are firmly in charge of much of their own risk of cancer.

Continue reading “Here’s How to Prevent Half of Cancer Deaths” »

This new SF Weekly story is one of the best long features on transhumanism I’ve ever read. It covers a myriad of futurist subjects. It’s out in print today too.

When John Lennon released “Imagine” in 1971, his lyrics about a brotherhood of man living life in peace struck many people as a simple, even anodyne, response to the Vietnam War. Although politically liberal, Lennon was no doctrinal Marxist — only three years earlier, his song “Revolution” had shrugged off people who “go carrying pictures of Chairman Mao.” But the song struck many evangelical Christians as ghoulish, and for some, “Imagine” eventually came to be a sort of national anthem for the repressively secular, globalist state that was thought to be emerging: the anti-Christian New World Order that later became talk-radio conspiracy theorist Alex Jones’ fever dream.

Left Behind, a series of 16 books written between 1995 and 2007 that details a possible end-of-the-world scenario, starting from when all good Christians go to heaven in an instant (the Rapture) until the Second Coming of Jesus Christ, specifically calls out “Imagine” as a weapon in Satan’s arsenal of seductive propaganda. The Antichrist in Left Behind is a suave, cosmopolitan Romanian named Nicolae Carpathia — the product of the fused sperm of two gay atheist academics, as it happens — who uses the global confusion in the aftermath of the Rapture to become Secretary General of the U.N. and eventually dictator of a world government that tattoos its citizens with the Mark of the Beast, damning them for eternity.

Continue reading “The Future Is Now for the Transhumanist Party” »

As specialists gather in private to discuss a grand plan for constructing a human genome, Drew Endy and Laurie Zoloth argue that such an enormous moral gesture should not be discussed behind closed doors.

Credit: Mario Tama/Getty Images.

At Harvard today, an invitation-only group of about 150 scientists, lawyers, and entrepreneurs, met to discuss if and how to construct from scratch an entire human genome – the heritable genetic material that in nature is transferred from parents to children.

George Church, a professor of genetics at Harvard Medical School and an organizer of the proposed project, said there had been a misunderstanding. The project was not aimed at creating people, just cells, and would not be restricted to human genomes, he said. Rather it would aim to improve the ability to synthesize DNA in general, which could be applied to various animals, plants and microbes.

The project poses ethical issues about whether humans could be created without parents.

What are epigenetic modifications, and how might they play out across generations?

By Jen Christiansen on May 12, 2016.

Very nice.

The Food and Drug Administration has given so-called “breakthrough” status to a treatment that uses the once-feared polio virus to target aggressive forms of brain cancer, in the hope of speeding it to market.

The therapy, developed at Duke University, hopes to use the virus’ debilitating properties to help fight cancer instead of harming its host, CBS News reported Thursday.

Continue reading “FDA fast-tracks treatment that uses polio virus to fight brain cancer” »