Lifeboat Foundation

Life’s evolutionary timescale is typically calibrated to the oldest fossil occurrences. However, the veracity of fossil discoveries from the early Archaean period has been contested^11,12. Relaxed Bayesian node-calibrated molecular clock approaches provide a means of integrating the sparse fossil and geochemical record of early life with the information provided by molecular data; however, constraining LUCA’s age is challenging due to limited prokaryote fossil calibrations and the uncertainty in their placement on the phylogeny. Molecular clock estimates of LUCA^13,14,15 have relied on conserved universal single-copy marker genes within phylogenies for which LUCA represented the root. Dating the root of a tree is difficult because errors propagate from the tips to the root of the dated phylogeny and information is not available to estimate the rate of evolution for the branch incident on the root node. Therefore, we analysed genes that duplicated before LUCA with two (or more) copies in LUCA’s genome¹⁶. The root in these gene trees represents this duplication preceding LUCA, whereas LUCA is represented by two descendant nodes. Use of these universal paralogues also has the advantage that the same calibrations can be applied at least twice. After duplication, the same species divergences are represented on both sides of the gene tree^17,18 and thus can be assumed to have the same age. This considerably reduces the uncertainty when genetic distance (branch length) is resolved into absolute time and rate. When a shared node is assigned a fossil calibration, such cross-bracing also serves to double the number of calibrations on the phylogeny, improving divergence time estimates. We calibrated our molecular clock analyses using 13 calibrations (see ‘Fossil calibrations’ in Supplementary Information). The calibration on the root of the tree of life is of particular importance. Some previous studies have placed a younger maximum constraint on the age of LUCA based on the assumption that life could not have survived Late Heavy Bombardment (LHB) (~3.7–3.9 billion years ago (Ga))¹⁹. However, the LHB hypothesis is extrapolated and scaled from the Moon’s impact record, the interpretation of which has been questioned in terms of the intensity, duration and even the veracity of an LHB episode^20,21,22,23. Thus, the LHB hypothesis should not be considered a credible maximum constraint on the age of LUCA. We used soft-uniform bounds, with the maximum-age bound based on the time of the Moon-forming impact (4,510 million years ago (Ma) ± 10 Myr), which would have effectively sterilized Earth’s precursors, Tellus and Theia¹³. Our minimum bound on the age of LUCA is based on low δ⁹⁸ Mo isotope values indicative of Mn oxidation compatible with oxygenic photosynthesis and, therefore, total-group Oxyphotobacteria in the Mozaan Group, Pongola Supergroup, South Africa^24,25, dated minimally to 2,954 Ma ± 9 Myr (ref. ²⁶).

Our estimates for the age of LUCA are inferred with a concatenated and a partitioned dataset, both consisting of five pre-LUCA paralogues: catalytic and non-catalytic subunits from ATP synthases, elongation factor Tu and G, signal recognition protein and signal recognition particle receptor, tyrosyl-tRNA and tryptophanyl-tRNA synthetases, and leucyl-and valyl-tRNA synthetases²⁷. Marginal densities (commonly referred to as effective priors) fall within calibration densities (that is, user-specified priors) when topologically adjacent calibrations do not overlap temporally, but may differ when they overlap, to ensure the relative age relationships between ancestor-descendant nodes. We consider the marginal densities a reasonable interpretation of the calibration evidence given the phylogeny; we are not attempting to test the hypothesis that the fossil record is an accurate temporal archive of evolutionary history because it is not²⁸.

“We think these objects came from the inner and/or outer main asteroid belt, and the implication of that is that this is another mechanism for getting some ice into the inner solar system,” said Aster Taylor.

What are dark comets and how are they responsible for delivering water to the Earth? This is what a recent study published in Icarus hopes to address as a team of international researchers investigated the origins of dark comets and their evolution throughout the history of the solar system, including how much water they could have potentially brought to Earth in the past. This study holds the potential to help astronomers better understand dark comets and the formation and evolution of planetary bodies throughout the solar system.

Dark comets are often described as being a combination of asteroids and classified based on their unique behaviors, specifically their ability to accelerate without the aid of gravitational means, which researchers have previously hypothesized to be invisible gas jets emanating like traditional comets. Additionally, their physical characteristics consist of dark surfaces that could be hiding an icy subsurface, whereas traditional comets exhibit icy characteristics directly on their surface.

Continue reading “Dark Comets and the Potential Delivery of Water to Earth” »

In 2006, just a few years after the fruit fly genome had been sequenced, geneticists at the University of California, Davis, made a startling discovery: Several new genes had cropped up, seemingly out of nowhere.

These “de novo genes” weren’t simply new variants of existing ones; they had sprung forth from the supposedly inert spaces in between the coding sections of DNA—regions long dismissed as the junkyards of the double helix. Since the days of Darwin, such sprightly biological change agents had never before been seen.

A young graduate student at the time, Li Zhao was so intrigued that upon graduating in 2011, she set out to join the lab of David Begun, where the discovery was first made. She soon revealed that these little genetic big bangs happen all the time­­—over the past decade, she and her team have identified more than 500 de novo genes in the Drosophila lineage alone.

“Of all currently known temperate exoplanets, LHS 1,140 b could well be our best bet to one day indirectly confirm liquid water on the surface of an alien world beyond our Solar System,” said Charles Cadieux.

The search for Earth’s twin just got a little closer as astronomers recently presented findings regarding a potential icy or watery “super-Earth” called LHS 1,140 b, which is located approximately 49 light-years from Earth and whose radius is approximately 1.7 times our planet, along with orbiting within its star’s habitable zone. What makes this finding unique is LHS 1,140 b was previously hypothesized to be a mini-Neptune and astronomers speculate could be completely covered in either ice or water.

The findings were recently accepted to The Astrophysical Journal Letters and hold the potential to help astronomers better understand the formation and evolution of exoplanets, and specifically Earth-sized exoplanets within their star’s habitable zone.

Continue reading “LHS 1140 b: From Mini-Neptune to Potential Water World” »

The largest animals do not have proportionally bigger brains — with humans bucking this trend — a new study published in Nature Ecology and Evolution has revealed.

Researchers at the University of Reading and Durham University collected an enormous dataset of brain and body sizes from around 1,500…

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Continue reading “Brain size riddle solved as humans exceed evolution trend” »

The largest animals do not have proportionally bigger brains—with humans bucking this trend—a study published in Nature Ecology & Evolution has revealed.

Researchers at the University of Reading and Durham University collected an enormous dataset of brain and body sizes from around 1,500 species to clarify centuries of controversy surrounding brain size evolution.

Bigger brains relative to body size are linked to intelligence, sociality, and behavioral complexity—with humans having evolved exceptionally large brains. The new research reveals the largest animals do not have proportionally bigger brains, challenging long-held beliefs about brain evolution.

A research team has constructed a coherent superposition of quantum evolution with two opposite directions in a photonic system and confirmed its advantage in characterizing input-output indefiniteness. The study was published in Physical Review Letters.

The notion that time flows inexorably from the past to the future is deeply rooted in people’s mind. However, the laws of physics that govern the motion of objects in the microscopic world do not deliberately distinguish the direction of time.

To be more specific, the basic equations of motion of both classical and quantum mechanics are reversible, and changing the direction of the time coordinate system of a dynamical process (possibly along with the direction of some other parameters) still constitutes a valid evolution process.

Stern, R.J., Gerya, T.V. Sci Rep 14, 8,552 (2024). https://doi.org/10.1038/s41598-024-54700-x.

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Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind. But a team led by Penn State researchers has found a way to reprogram disease evolution and design tumors that are easier to treat.

They created a modular genetic circuit that turns cancer cells into a “Trojan horse,” causing them to self-destruct and kill nearby drug-resistant cancer cells. Tested in human cell lines and in mice as proof of concept, the circuit outsmarted a wide range of resistance.

The findings were published today, July 4, in the journal Nature Biotechnology. The researchers also filed a provisional application to patent the technology described in the paper.