Lifeboat Foundation

Macrophages, small but essential cells in the immune system, hold promise for cell-based therapies in numerous health conditions. Unlocking the full potential of macrophage therapies depends on our ability to observe their activities within the body. Now, researchers from Penn State have potentially developed a method to monitor these cells in action.

In a study published in the journal Small, the Penn State researchers report a novel ultrasound imaging technique to view macrophages continuously in mammal tissue, with potential for human application in the future.

“A macrophage is a type of immune cell that is important in nearly every function of the immune system, from detecting and clearing pathogens to wound healing,” said corresponding author Scott Medina, the William and Wendy Korb Early Career Associate Professor of Biomedical Engineering. “It is a component of the immune system that really bridges the two types of immunity: innate immunity, which responds to things very quickly but in a not very precise way, and adaptive immunity, which is much slower to come online but responds in a much more precise way.”

Security researchers bypassed Windows Hello fingerprint authentication on Dell Inspiron, Lenovo ThinkPad, and Microsoft Surface Pro X laptops in attacks exploiting security flaws found in the embedded fingerprint sensors.

Blackwing Intelligence security researchers discovered vulnerabilities during research sponsored by Microsoft’s Offensive Research and Security Engineering (MORSE) to assess the security of the top three embedded fingerprint sensors used for Windows Hello fingerprint authentication.

Continue reading “Windows Hello auth bypassed on Microsoft, Dell, Lenovo laptops” »

An advancement in neutron shielding, a critical aspect of radiation protection, has been achieved. This breakthrough is poised to revolutionize the neutron shielding industry by offering a cost-effective solution applicable to a wide range of materials surfaces.

A research team, led by Professor Soon-Yong Kwon in the Graduate School of Semiconductors Materials and Devices Engineering and the Department of Materials Science and Engineering at UNIST has successfully developed a neutron shielding film capable of blocking neutrons present in radiation. This innovative shield is not only available in large areas but also lightweight and flexible.

The team’s paper is published in the journal Nature Communications.

MIT researchers and colleagues have demonstrated a way to precisely control the size, composition, and other properties of nanoparticles key to the reactions involved in a variety of clean energy and environmental technologies. They did so by leveraging ion irradiation, a technique in which beams of charged particles bombard a material.

They went on to show that nanoparticles created this way have superior performance over their conventionally made counterparts.

“The materials we have worked on could advance several technologies, from fuel cells to generate CO₂-free electricity to the production of clean hydrogen feedstocks for the chemical industry [through electrolysis cells],” says Bilge Yildiz, leader of the work and a professor in MIT’s Department of Nuclear Science and Engineering and Department of Materials Science and Engineering.

Autoimmune disorders are among the most prevalent chronic diseases across the globe. Emerging treatments for autoimmune disorders focus on “adoptive cell therapies,” or those using cells from a patient’s own body to achieve immunosuppression. These therapeutic cells are recognized by the patient’s body as “self,” therefore limiting side effects, and are specifically engineered to localize the intended therapeutic effect.

In treating autoimmune diseases, current adoptive cell therapies have largely centered around the regulatory T cell (T_reg), which is defined by the expression of the Forkhead box protein 3, orFoxp3. Although T_regs offer great potential, using them for therapeutic purposes remains a major challenge. In particular, current delivery methods result in inefficient engineering of T cells.

T_regs only compose approximately 5%–10% of circulating peripheral blood mononuclear cells. Furthermore, T_regs lack more specific surface markers that differentiate them from other T cell populations. These hurdles make it difficult to harvest, purify and grow T_regs to therapeutically relevant numbers. Although there are additional tissue-resident T_regs in non-lymphoid organs such as in skeletal muscle and visceral adipose tissue, these T_regs are severely inaccessible and low in number.

A new device that can be swallowed like a pill can track vital signs such as breathing and heart rate from inside the body.

Left: Ben Pless Right: Traverso Lab at Brigham and Women’s Hospital.

“This device can help diagnose and monitor many health conditions without requiring hospital visits, which can make healthcare more accessible and supportive for patients,” says Giovanni Traverso, the lead author of the study, an associate professor of mechanical engineering at MIT and a gastroenterologist at Brigham and Women’s Hospital.

Continue reading “Swallowable device tracking vital signs inside the body in human trial” »

Metamaterials are products of engineering wizardry. They are made from everyday polymers, ceramics, and metals. And when constructed precisely at the microscale, in intricate architectures, these ordinary materials can take on extraordinary properties.

With the help of computer simulations, engineers can play with any combination of microstructures to see how certain materials can transform, for instance, into sound-focusing acoustic lenses or lightweight, bulletproof films.

But simulations can only take a design so far. To know for sure whether a metamaterial will stand up to expectation, physically testing them is a must. But there’s been no reliable way to push and pull on metamaterials at the microscale, and to know how they will respond, without contacting and physically damaging the structures in the process.

As information and communication technologies (ICT) process data, they convert electricity into heat. Already today, the global ICT ecosystem’s CO₂ footprint rivals that of aviation. It turns out, however, that a big part of the energy consumed by computer processors doesn’t go into performing calculations. Instead, the bulk of the energy used to process data is spent shuttling bytes between the memory to the processor.

In a paper published in the journal Nature Electronics, researchers from EPFL’s School of Engineering in the Laboratory of Nanoscale Electronics and Structures (LANES) present a new processor that tackles this inefficiency by integrating data processing and storage onto a single device, a so-called in-memory processor.

They broke new ground by creating the first in-memory processor based on a two-dimensional semiconductor material to comprise more than 1,000 transistors, a key milestone on the path to industrial production.

https://youtube.com/watch?v=pBk6TweYZHE

The most powerful telescope ever built.

The James Webb Space Telescope (JWST) is a space telescope that has been designed to study the universe in infrared light. It is the largest and most powerful telescope ever built, and it is the successor to the Hubble Space Telescope.
JWST was launched on December 25, 2021, and it is now operational. The telescope is located at the second Lagrange point (L2) of the Sun-Earth system, which is about 1.5 million kilometers (930,000 miles) from Earth.

Continue reading “James Webb Space Telescope” »