Lifeboat Foundation

Exciting.

The search for the chemical origins of life represents a long-standing and continuously debated enigma. Despite its exceptional complexity, in the last decades the field has experienced a revival, also owing to the exponential growth of the computing power allowing for efficiently simulating the behavior of matter—including its quantum nature—under disparate conditions found, e.g., on the primordial Earth and on Earth-like planetary systems (i.e., exoplanets). In this minireview, we focus on some advanced computational methods capable of efficiently solving the Schrödinger equation at different levels of approximation (i.e., density functional theory)—such as ab initio molecular dynamics—and which are capable to realistically simulate the behavior of matter under the action of energy sources available in prebiotic contexts.

Some classical computers have error correction built into their memories based on bits; quantum computers, to be workable in the future, will need error correction mechanisms, too, based on the vastly more sensitive qubits.

Cornell researchers have recently taken a step toward fault-tolerant quantum computing: they constructed a simple model containing exotic particles called non-Abelian anyons, compact and practical enough to run on modern quantum hardware. Realizing these particles, which can only exist in two dimensions, is a move towards implementing it in the real world.

Thanks to some creative thinking, Yuri Lensky, a former Bethe/Wilkins/Kavli Institute at Cornell (KIC) postdoctoral fellow in physics in the College of Arts and Sciences (A&S), collaborating with Eun-Ah Kim, professor of physics (A&S), came up with a simple “recipe” that could be used for robustly computing with non-Abelian anyons, including specific instructions for executing the effect experimentally on devices available today.

Hoping to improve on those earlier efforts, Matthew Daugherty, a biochemist at the University of California San Diego, and colleagues used sophisticated computer software to trace the evolution of hundreds of human genes by searching for similar sequences in hundreds of other species. Genes that seemed to have appeared first in vertebrates and had no predecessors in earlier animals were good candidates for having jumped across from bacteria, particularly if they had counterparts in modern microbes. Among the dozens of potentially alien genes, one “blew me away,” Daugherty recalls.

The gene, called IRBP (for interphotoreceptor retinoid-binding protein), was already known to be important for seeing. The protein it encodes resides in the space between the retina and the retinal pigment epithelium, a thin layer of cells overlying the retina. In the vertebrate eye, when light hits a light-sensitive photoreceptor in the retina, vitamin A complexes become kinked, setting off an electrical pulse that activates the optic nerve. IRBP then shifts these molecules to the epithelium to be unkinked. Finally, it shuttles the restored molecules back to the photoreceptor. “IRBP,” Zhu explains, “is essential for the vision of all vertebrates.”

Vertebrate IRBP most closely resembles a class of bacterial genes called pepsidases, whose proteins recycle other proteins. Since IRBP is found in all vertebrates but generally not in their closest invertebrate relatives, Daugherty and his colleagues propose that more than 500 million years ago microbes transferred a pepsidase gene into an ancestor of all living vertebrates. Once the gene was in place, the protein’s recycling function was lost and the gene duplicated itself twice, explaining why IRBP has four copies of the original pepsidase DNA. Even in its microbial forebears, this protein may have had some ability to bind to light-sensing molecules, Daugherty suggests. Other mutations then completed its transformation into a molecule that could escape from cells and serve as a shuttle.

Every time a person dies, writes Russian novelist Vasily Grossman in Life and Fate, the entire world that has been built in that individual’s consciousness dies as well: “The stars have disappeared from the night sky; the Milky Way has vanished; the sun has gone out… flowers have lost their color and fragrance; bread has vanished; water has vanished.” Elsewhere in the book, he writes that one day we may engineer a machine that can have human-like experiences; but if we do, it will have to be enormous—so vast is this space of consciousness, even within the most “average, inconspicuous human being.”

And, he adds, “Fascism annihilated tens of millions of people.” Trying to think those two thoughts together is a near-impossible feat, even for the immense capacities of our consciousness. But will machine minds ever acquire anything like our ability to have such thoughts, in all their seriousness and depth? Or to reflect morally on events, or to equal our artistic and imaginative reach? Some think that this question distracts us from a more urgent one: we should be asking what our close relationship with our machines is doing to us.

Jaron Lanier, himself a pioneer of computer technology, warns in You Are Not a Gadget that we are allowing ourselves to become ever more algorithmic and quantifiable, because this makes us easier for computers to deal with. Education, for example, becomes less about the unfolding of humanity, which cannot be measured in units, and more about tick boxes.

The GPT phenomenon and the future of humanity in the face of advances in Artificial Intelligence.

The Age of Artificial Intelligence is an increasingly present reality in our daily lives. With the rise of technologies such as Natural Language Processing (NLP) and Artificial Neural Networks (ANN), the possibility of creating machines capable of performing tasks that were previously exclusive to humans has emerged.

One of these technologies is the Generative Pre-trained Transformer, better known as GPT. It’s the Large Language Model (LLM) developed by OpenAI.

OpenAI was founded in San Francisco, California in 2015 by Sam Altman, Reid Hoffman, Jessica Livingston, Elon Musk, Ilya Sutskever, Peter Thiel, among others, who collectively pledged $1 billion. Musk resigned from the board in 2018, but continued to be a donor to the project.

Continue reading “Intelligence Explosion — Part 1/3” »

This paper aims to promote a quantum framework that analyzes Industry 4.0 cyber-physical systems more efficiently than traditional simulations used to represent integrated systems. The paper proposes a novel configuration of distributed quantum circuits in multilayered complex networks that enable the evaluation of industrial value creation chains. In particular, two different mechanisms for the integration of information between circuits operating at different layers are proposed, where their behavior is analyzed and compared with the classical conditional probability tables linked to the Bayesian networks. With the proposed method, both linear and nonlinear behaviors become possible while the complexity remains bounded. Applications in the case of Industry 4.0 are discussed when a component’s health is under consideration, where the effect of integration between different quantum cyber-physical digital twin models appears as a relevant implication.

Subject terms: Quantum simulation, Qubits.

Cyber-physical systems (CPS) are integrations of computational and physical components that can interact with humans through new and different modalities. A key to future technological development is precisely this new and different capacity of interaction together with the new possibilies that these systems pose for expanding the capabilities of the physical world through computation, communication and control¹. When CPS are understood within the industrial practice fueled by additional technologies such as Internet of Things (IoT), people refer to the Industry 4.0 paradigm². The design of many industrial engineering systems has been performed by separately considering the control system design from the hardware and/or software implementation details.

Playlist: https://www.youtube.com/playlist?list=PLnK6MrIqGXsJfcBdppW3CKJ858zR8P4eP
Download PowerPoint: https://github.com/hywong2/Intro_to_Quantum_Computing.
Book (Free with institution subscription): https://link.springer.com/book/10.1007/978-3-030-98339-0
Book: https://www.amazon.com/Introduction-Quantum-Computing-Layper…atfound-20

Can quantum computing replace classical computing? State, Superposition, Measurement, Entanglement, Qubit Implementation, No-cloning Theorem, Error Correction, Caveats.

Ludovico Lami of QuSoft and the University of Amsterdam and Mark M. Wilde of Cornell have achieved a major breakthrough in the field of quantum computing by developing a formula that predicts the impact of environmental noise. This formula is critical in the creation of quantum computers that can wo.

How can flesh and blood brains give rise to pains and pleasures, dreams and desires, sights and sounds? Some believe this ‘hard problem’ of consciousness can never be solved. Can we expect any breakthroughs as the science of the mind progresses?

Our annual debate this year considers whether the problem of consciousness really is intractable. Our illustrious panel is neuroscientist Anil Seth and philosophers Louise Antony, Maja Spener and Philip Goff, with the BBC’s Ritula Shah chairing.

Continue reading “‘Can Consciousness be Explained?’ — Royal Institute of Philosophy Annual Debate 2023” »