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Category: chemistry – Page 45

Dr. Aliza Apple, Ph.D. — VP, Catalyze360 AI/ML and Global Head, Lilly TuneLab, Eli Lilly

Accelerating Promising Biotech Innovation — Dr. Aliza Apple, Ph.D. — Vice President, Catalyze360 AI/ML and Global Head, Lilly TuneLab, Eli Lilly and Company.

Dr. Aliza Apple, Ph.D. is a Vice President of Catalyze360 AI (https://www.lilly.com/science/partners/catalyze-360 and Global Head of Lilly TuneLab (https://tunelab.lilly.com/) at Eli Lilly where she leads the strategy, build and launch of Lilly’s external-facing AI/ML efforts for drug discovery.

Lilly Catalyze360 represents a comprehensive approach to enabling the early-stage biotech ecosystem, agnostic of the therapeutic area, designed to accelerate emerging and promising science, strategically removing barriers to support biotech innovation.

In her previous role at Lilly, Dr. Apple served as the COO and head of Lilly Gateway Labs West Coast, where she supported the local biotech ecosystem through early engagement and providing tailored offerings to meet their needs.

Prior to Lilly, Dr. Apple served as a co-founder at Santa Ana Bio, a venture-backed precision biologics company focused on autoimmune disease, and as an advisor to the founders of Firefly Biologics.

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Researchers discover a hidden atomic order that persists in metals even after extreme processing

For decades, it’s been known that subtle chemical patterns exist in metal alloys, but researchers thought they were too minor to matter—or that they got erased during manufacturing. However, recent studies have shown that in laboratory settings, these patterns can change a metal’s properties, including its mechanical strength, durability, heat capacity, radiation tolerance, and more.

Now, researchers at MIT have found that these chemical patterns also exist in conventionally manufactured metals. The surprising finding revealed a new physical phenomenon that explains the persistent patterns.

In a paper published in Nature Communications today, the researchers describe how they tracked the patterns and discovered the physics that explains them. The authors also developed a simple model to predict chemical patterns in metals, and they show how engineers could use the model to tune the effect of such patterns on metallic properties, for use in aerospace, semiconductors, nuclear reactors, and more.

Research shines light on ‘double-yielding’ behavior in soft materials

For decades, scientists have observed, but been unable to explain, a phenomenon seen in some soft materials: When force is applied, these materials exhibit not one, but two spikes in energy dissipation, known as overshoots. Because overshoots are generally thought to indicate the point at which a material yields, or transitions from solid-like to fluid-like behavior, the dual response was therefore assumed to indicate “double yielding”—the idea that to fully fluidize a material, it needed to yield twice.

Now, researchers at the University of Illinois Urbana-Champaign have shown that this behavior is different than previously hypothesized. Their paper, “Resolving Dual Processes in Complex Oscillatory Yielding,” is published in Physical Review Letters.

In the study, chemical and biomolecular engineering professor Simon A. Rogers and his team, led by then-graduate student James J. Griebler show that the two-step response is the result of two independent processes: first, a softening of the material’s elastic structure, and later, true yielding.

Astronomers discover the most ‘pristine’ star in the known universe

Not all stars are created equally. Astronomers believe that the first stars to form after the Big Bang were mostly made of only hydrogen and helium with trace amounts of lithium, as the heavier elements formed later on by nuclear fusion inside the stars. When these stars went supernova, heavier elements spread throughout space and formed more stars. Each successive generation contained more heavy elements, and these elements also became successively heavier.

While most stars still contain mostly hydrogen and helium, they now contain many as well, especially as they get older. These elements show up in spectrographic data when astronomers gather light from these . Stars are considered “pristine” when the data shows a lack of heavy elements—meaning they are likely very rare, older stars from earlier generations. And now, a group of astronomers, led by Alexander Ji from the University of Chicago, believe they have found the most pristine star on record. The group has documented their findings on the arXiv preprint server.

The star, referred to as SDSS J0715-7334, is a red giant purported to have the lowest metallicity—or heavy element content—ever found. The team’s detailed spectral and shows that SDSS J0715-7334 has a total metallicity “Z” of less than 7.8 × 10-7. This is compared to the next lowest metallicity star currently known, a star located in the Milky Way with a total metallicity of around 1.4 × 10-6.

Cassini proves complex chemistry in Enceladus ocean

Scientists digging through data collected by the Cassini spacecraft have found new complex organic molecules spewing from Saturn’s moon Enceladus. This is a clear sign that complex chemical reactions are taking place within its underground ocean. Some of these reactions could be part of chains that lead to even more complex, potentially biologically relevant molecules.

Published in Nature Astronomy, this discovery further strengthens the case for a dedicated European Space Agency (ESA) mission to orbit and land on Enceladus.

In 2005, Cassini found the first evidence that Enceladus has a hidden ocean beneath its icy surface. Jets of water burst from cracks close to the moon’s south pole, shooting ice grains into space. Smaller than grains of sand, some of the tiny pieces of ice fall back onto the moon’s surface, while others escape and form a ring around Saturn that traces Enceladus’s orbit.

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