Lifeboat Foundation

Vanderbilt researchers have developed a new nanoparticle that can more get drugs inside cells to boost the immune system and fight diseases such as cancer.

The research is led by John Wilson, associate professor of chemical and biomolecular engineering and biomedical engineering, as well as a corresponding author on the paper about the research that was recently published in the journal Nanoscale.

Wilson, who is Principal Investigator of the Immunoengineering Lab at Vanderbilt and a Chancellor Faculty Fellow, and his team created a polymeric nanoparticle that can penetrate cell membranes and get drugs into the cytosol—or liquid—inside cells.

Dr. John Swierk: “This is also the first study to explicitly look at inks sold in the United States and is probably the most comprehensive because it looks at the pigments, which nominally stay in the skin, and the carrier package, which is what the pigment is suspended in.”

Do the ingredients in tattoo inks match the labels on their respective bottles? This is what a recent study published in Analytical Chemistry hopes to address as a team of researchers from Binghamton University investigated the accuracy of ink ingredients and what’s labeled on their containers. This study holds the potential to help scientists, artists, and their customers better understand the health risks, to include allergic reactions and other risks, of using the wrong ink ingredients for tattoos.

For the study, the researchers examined ingredients from 54 inks emanating from nine common brands within the United States with the goal of ascertaining their exact chemical compositions compared to what was labeled on their respective bottles. In the end, the researchers identified that 45 of the 54 inks possessed a myriad of pigments and/or additives that were not properly labeled on the bottles that could pose health risks to customers receiving ink tattoos, including allergic skin reactions and other long-term health risks, including non-skin-related risks, such as cancer. Despite the alarming findings, the researchers could not ascertain which unlisted ingredients were intentionally or accidentally added to the inks.

Continue reading “Ink Alert: Discrepancies Found in Tattoo Ink Composition” »

The speed of innovation in bioelectronics and critical sensors gets a new boost with the unveiling of a simple, time-saving technique for the fast prototyping of devices.

A research team at KTH Royal Institute of Technology and Stockholm University reported a simple way to fabricate electrochemical transistors using a standard Nanoscribe 3D micro printer. Without cleanroom environments, solvents, or chemicals, the researchers demonstrated that 3D micro printers could be hacked to laser print and micropattern semiconducting, conducting, and insulating polymers.

Anna Herland, professor in Micro-and Nanosystems at KTH, says the printing of these polymers is a key step in prototyping new kinds of electrochemical transistors for medical implants, wearable electronics and biosensors.

A new study from a team of McGill University and Vanderbilt University researchers is shedding light on our understanding of the molecular origins of some forms of autism and intellectual disability.

For the first time, researchers were able to successfully capture atomic resolution images of the fast-moving ionotropic glutamate receptor (iGluR) as it transports calcium. iGluRs and their ability to transport calcium are vitally important for many brain functions such as vision or other information coming from sensory organs. Calcium also brings about changes in the signaling capacity of iGluRs and nerve connections, which are key cellular events that lead to our ability to learn new skills and form memories.

IGluRs are also key players in brain development and their dysfunction through genetic mutations has been shown to give rise to some forms of autism and intellectual disability. However, basic questions about how iGluRs trigger biochemical changes in the brain’s physiology by transporting calcium have remained poorly understood.

Explaining isolated steps on the road from simple chemicals to complex living organisms is not enough. Looking at the big picture could help to bridge rifts in this fractured research field.

Studying a rock is like reading a book. The rock has a story to tell, says Frieder Klein, an associate scientist in the Marine Chemistry & Geochemistry Department at the Woods Hole Oceanographic Institution (WHOI).

The rocks that Klein and his colleagues analyzed from the submerged flanks of the St. Peter and St. Paul Archipelago in the St. Paul’s oceanic transform fault, about 500 km off the coast of Brazil, tell a fascinating and previously unknown story about parts of the geological carbon cycle.

Transform faults, where tectonic plates move past each other, are one of three main plate boundaries on Earth and about 48,000 km in length globally, with the others being the global mid-ocean ridge system (about 65,000 km) and subduction zones (about 55,000 km).

Longstanding challenges in biomedical research such as monitoring brain chemistry and tracking the spread of drugs through the body require much smaller and more precise sensors. A new nanoscale sensor that can monitor areas 1,000 times smaller than current technology and can track subtle changes in the chemical content of biological tissue with sub-second resolution, greatly outperforming standard technologies.

The device, developed by researchers at the University of Illinois Urbana-Champaign, is silicon-based and takes advantage of techniques developed for microelectronics manufacturing. The small device size enables it to collect chemical content with close to 100% efficiency from highly localized regions of tissue in a fraction of a second. The capabilities of this new nanodialysis device are reported in the journal ACS Nano.

“With our nanodialysis device, we take an established technique and push it into a new extreme, making biomedical research problems that were impossible before quite feasible now,” said Yurii Vlasov, a U. of I. electrical & computer engineering professor and a co-lead of the study. “Moreover, since our devices are made on silicon using microelectronics fabrication techniques, they can be manufactured and deployed on large scales.”

The search for habitable exoplanets involves looking for planets with similar conditions to the Earth, such as liquid water, a suitable temperature range and atmospheric conditions. One crucial factor is the planet’s position in the habitable zone, the region around a star where liquid water could potentially exist on the planet’s surface. NASA’s Kepler telescope, launched in 2009, revealed that 20–50% of visible stars may host such habitable Earth-sized rocky planets. However, the presence of liquid water alone does not guarantee a planet’s habitability. On Earth, carbon compounds such as carbon dioxide (CO₂), methane (CH4), and carbon monoxide (CO) played a crucial role in shaping the climate and biogeochemistry and could have contributed to the emergence of life.

Taking this into consideration, a recent study by Associate Professor Kazumi Ozaki from Tokyo Institute of Technology, along with Associate Researcher Yasuto Watanabe from The University of Tokyo, aims to expand the search for habitable planets. Published in the Astrophysical Journal(External site) on 10 January 2024, the researchers used atmospheric modeling to identify conditions that could result in a CO-rich atmosphere on Earth-like planets that orbit sun-like (F-, G-, and K-type) stars. This phenomenon, known as CO runaway, is suggested by atmospheric models to have possibly occurred in early planetary atmospheres, potentially favoring the emergence of life.

“The possibility of CO runaway is critical in resolving the fundamental problem regarding the origin of life on Earth because various organic compounds suitable for the prebiotic chemistry are more likely to form in a CO-rich atmosphere than in a CO2-rich atmosphere,” explains Dr. Ozaki.

RuO2 has been established as the benchmark catalyst for the oxygen evolution reaction (OER). However, the low precious metal content compared to other OER industrial catalysts like RuO2, Pt/C, and IrO2 makes a hybrid heterosurface of RuO2 and F-doped graphene (RuO2@FGr) an excellent catalyst with a high current density. Moreover, the advantage of graphene support increases stability. We investigated the mechanism of the OER on RuO2@FGr using density functional theory (DFT) and the computational hydrogen electrode model (CHEM). In CHEM, the adsorption energy of the reactive intermediates is considered for the reduction potential calculation. This is followed by free energy calculation and, eventually, overpotential calculation using standard or reversible hydrogen electrodes (SHE/RHE). Computational OER activity calculated in the gas phase using density functional theory (DFT) cannot explain the contribution of the condensed phase, water organization energy, the kinetics of the elementary steps, and electrochemical contribution. The current study will address the issue by implementing an implicit solvation model and the electrostatic contribution by considering the charge extrapolation model. We used molecular RuO2 to mimic the exact experimental weight percentage. Fluorine intercalation doping improves the binding of oxygen-based intermediate species to the reactive surface due to a shift in the d-band center toward the Fermi level. The graphene sheet behaves as a conductor after fluorine doping, and the electron density contribution near the Fermi level is clearly distinguished from the projected density of states (PDOS). Using the implicit solvation model with altered parameters, we find improvements in the reaction barrier for hydroperoxo formation. An overpotential of 0.40 V vs RHE is obtained for the cavity shape parameter and charge density cutoff parameter of 0.8 and 0.0035 Å–3. For completion, we implement the constant potential model (CPM) to extrapolate our results calculated at the nonzero potential environment to 0.0 V potential. The mean energy path computed using the climbing image nudged elastic band provides the activation and reaction energy, and the values are extrapolated to 0.0 V RHE using the CPM correction. Implementing both thermochemical and electrochemical corrections simultaneously, we can find a reasonable overpotential of the studied catalytic reaction.