A study led by Professor Shimpei Gotoh (Department of Clinical Application), introduces a new culturing method to generate alveolar organoids suitable for medium-and high-throughput screening and identified several chemicals with synergistic effects on AT1 cell differentiation. The work is published in the journal Stem Cell Reports.
Some molecules respond to external light pulses by changing their structure and holding certain states that can be switched from one to another. These are commonly referred to as photoswitches and usually have two possible states. Recently, however, scientists from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) have developed a molecule that takes the possibilities of photoswitches a step further.
More than two decades ago, scientists predicted that at ultra-low temperatures, many atoms could undergo ‘quantum superchemistry’ and chemically react as one. They’ve finally shown it’s real.
What do margaritas, vinegar, and ant stings have in common? They contain chemical ingredients that NASA’s James Webb Space Telescope has identified surrounding two young protostars known as IRAS 2A and IRAS 23385. Although planets are not yet forming around those stars, these and other molecules detected there by Webb represent key ingredients for making potentially habitable worlds.
An international team of astronomers used Webb’s MIRI (Mid-Infrared Instrument) to identify a variety of icy compounds made up of complex organic molecules like ethanol (alcohol) and likely acetic acid (an ingredient in vinegar). This work builds on previous Webb detections of diverse ices in a cold, dark molecular cloud.
What is the origin of complex organic molecules (COMs)?
“We hope our work will contribute to informed decisions regarding regulatory measures or behavioral interventions to minimize chemical exposure and protect human health,” Tesar said in a statement.
1.8 million. That’s how many people globally have multiple sclerosis, according to the World Health Organization. The agency also found around one in 100 children worldwide have been diagnosed with autism.
“Rigorous safety tests are in place for human health that are evaluated by [the] U.S. Environmental Protection Agency for approval and compliance with all regulatory guidelines,” Brian Sansoni, senior vice president for Communications, Outreach and Membership for the American Cleaning Institute, told Forbes. The ACI represents top cleaning product manufacturers like the Clorox Company and Procter & Gamble. “ACI member company manufacturers make product safety a top priority.” Quats have been known to be effective at killing bacteria, germs, viruses and mold. “The use of cleaning products, disinfectants and their chemistries contribute to public health in homes, schools, healthcare settings and communities every single day,” the ACI said.
As transistors get smaller, they become increasingly inefficient and susceptible to errors, as electrons can leak through the device even when it is supposed to be switched off, by a process known as quantum tunneling. Researchers are exploring new types of switching mechanisms that can be used with different materials to remove this effect.
In the nanoscale structures that Professor Jan Mol, Dr. James Thomas, and their group study at Queen Mary’s School of Physical and Chemical Sciences, quantum mechanical effects dominate, and electrons behave as waves rather than particles. Taking advantage of these quantum effects, the researchers built a new transistor.
The transistor’s conductive channel is a single zinc porphyrin, a molecule that can conduct electricity. The porphyrin is sandwiched between two graphene electrodes, and when a voltage is applied to the electrodes, electron flow through the molecule can be controlled using quantum interference.
Now Flinders University researchers have discovered a light-responsive, inexpensive sulfur-derived polymer receptive to low power, visible light lasers—which promises a more affordable and safer production method in nanotech, chemical science and patterning surfaces in biological applications.
Details of the novel system have just been published in Angewandte Chemie International Edition, featuring a laser-etched version of the famous “Mona Lisa” painting and micro-Braille printing even smaller than a pin head.
“This could be a way to reduce the need for expensive, specialized equipment, including high-power lasers with hazardous radiation risk, while also using more sustainable materials. For instance, the key polymer is made from low-cost elemental sulfur, an industrial byproduct, and either cyclopentadiene or dicyclopentadiene,” says Matthew Flinders Professor of Chemistry Justin Chalker, from the Flinders University.
Anyone who wants to produce medication, plastics or fertilizer using conventional methods needs heat for chemical reactions – but not so with photochemistry, where light provides the energy. The process to achieve the desired product also often takes fewer intermediate steps.
Researchers from the University of Basel are now going one step further and are demonstrating how the energy efficiency of photochemical reactions can be increased tenfold. More sustainable and cost-effective applications are now tantalizingly close.
Industrial chemical reactions usually occur in several stages across various interim products. Photochemistry enables shortcuts, meaning fewer intermediate steps are required. Photochemistry also allows you to work with less hazardous substances than in conventional chemistry, as light produces a reaction in substances which do not react well under heat. However, to this point there have not been many industrial applications for photochemistry, partly because supplying energy with light is often inefficient or creates unwanted by-products.
A recent study reveals how hydrogen gas, often touted as the energy source of tomorrow, provided energy in the past, at the origin of life 4 billion years ago. Hydrogen gas is clean fuel. It burns with oxygen in the air to provide energy with no CO2.
Hydrogen is a key to sustainable energy for the future. Though humans are just now coming to realize the benefits of hydrogen gas (H2 in chemical shorthand), microbes have known that H2 is a good fuel for as long as there has been life on Earth. Hydrogen is ancient energy.
The very first cells on Earth lived from H2 produced in hydrothermal vents, using the reaction of H2 with CO2 to make the molecules of life. Microbes that thrive from the reaction of H2 and CO2 can live in total darkness, inhabiting spooky, primordial habitats like deep-sea hydrothermal vents or hot rock formations deep within the Earth’s crust, environments where many scientists think that life itself arose.
There are trillions of microbes in the human gastrointestinal tract, each of which expresses its own genome, and carries out a variety of biochemical processes. Gut microbes can generate a variety of molecules that can have a significant impact on human health, such as vitamins, specially modified bile acids, and short-chain fatty acids (SCFAs).
SCFAs have fewer than six carbon atoms, and are found in a few major forms, including acetate, propionate, and butyrate. When we eat fibers that are tough to digest, gut microbes metabolize them instead, and generate SCFAs. Many links have been found between butyrate and human health; it is thought to have roles in the maintainence of epithelial barriers, prevention of gut inflammation in the gut and colorectal cancer, and oxidative stress relief.
