Lifeboat Foundation

YES!!!

Scientists at the Department of Energy’s National Renewable Energy Laboratory (NREL) have discovered a new approach for developing a rechargeable non-aqueous magnesium-metal battery.

A proof-of-concept paper published in Nature Chemistry detailed how the scientists pioneered a method to enable the reversible chemistry of magnesium metal in the noncorrosive carbonate-based electrolytes and tested the concept in a prototype cell. The technology possesses potential advantages over lithium-ion batteries—notably, higher energy density, greater stability, and lower cost.

Continue reading “Research overcomes major technical obstacles in magnesium-metal batteries” »

The first large-scale age-map of the Milky Way shows that a period of star formation lasting around 4 billion years created the complex structure at the heart of our galaxy. The results will be presented by Marina Rejkuba at the European Week of Astronomy and Space Science (EWASS) in Liverpool on Tuesday, 3rd April.

The Milky Way is a spiral galaxy with a bulge at the centre, thousands of light years in diameter, that contains about a quarter of the total mass of stars. Previous studies have shown that the bulge hosts two components: a population of metal-poor stars that have a spherical distribution, and a population of metal-rich stars that form an elongated bar with a “waist”, like an x or a bi-lobed peanut. However, analyses of the ages of the stars to date have produced conflicting results. Now, an international team led by astronomers from the European Southern Observatory (ESO) have analysed the colour, brightness and spectral information on chemistry of individual stars to produce the age-map of the Milky Way.

The team have used simulated and observed data for millions of stars from the VISTA Variables in the Via Lactea (VVV) infrared survey of the inner Milky Way and compared them with measurements of the metal content of around 6000 stars across the inner bulge from a spectroscopic survey carried out with the GIRAFFE/FLAMES spectrograph on the ESO Very Large Telescope (GIBS).

Not only can synthetic molecules mimic the structures of their biological models, they can also take on their functions and may even successfully compete with them, as an artificial DNA sequence designed by Ludwig-Maximilians-Universitaet (LMU) in Munich chemist Ivan Huc now shows.

Chemist Ivan Huc finds the inspiration for his work in the molecular principles that underlie biological systems. As the leader of a research group devoted to biomimetic supramolecular chemistry, he creates ‘unnatural’ molecules with defined, predetermined shapes that closely resemble the major biological polymers, proteins and DNA found in cells. The backbones of these molecules are referred to as ‘foldamers’ because, like origami patterns, they adopt predictable shapes and can be easily modified. Having moved to LMU from his previous position at Bordeaux University last summer, Huc has synthesized a helical molecule that mimics surface features of the DNA double helix so closely that bona fide DNA-binding proteins interact with it.

This work is described in a paper published in Nature Chemistry. The new study shows that the synthetic compound is capable of inhibiting the activities of several DNA-processing enzymes, including the ‘integrase’ used by the human immunodeficiency virus (HIV) to insert its genome into that of its host cell. The successful demonstration of the efficacy of the synthetic DNA mimic might lead to a new approach to the treatment of AIDS and other retroviral diseases.

Continue reading “Biomimetic chemistry—DNA mimic outwits viral enzyme” »

Today, our IBM Research team published the first real world demonstration of a rocking Brownian motor for nanoparticles in the peer-review journal Science. The motors propel nanoscale particles along predefined racetracks to enable researchers to separate nanoparticle populations with unprecedented precision. The reported findings show great potential for lab-on-a-chip applications in material science, environmental sciences or biochemistry.

No More Fairy Tales

Continue reading “IBM Scientists First to Demo Rocking Brownian Motors for Nanoparticles” »

Editor’s Note: The American Chemical Society is also issuing a press release today embargoed for 5am Eastern Time that can be requested at [email protected] or call 504−670−6721.

NEW ORLEANS, March 19, 2018 — Up until now, local inflammation and scar tissue from the so-called “foreign body response” has prevented the development of in-body sensors capable of continuous, long-term monitoring of body chemistry. But today scientists are presenting results showing tiny biosensors that become one with the body have overcome this barrier, and stream data to a mobile phone and to the cloud for personal and medical use.

“While fitness trackers and other wearables provide insights into our heart rate, respiration and other physical measures, they don’t provide information on the most important aspect of our health: our body’s chemistry,” explained Natalie Wisniewski, Ph.D. “Based on our ongoing studies, tissue-integrated sensor technology has the potential to enable wearables to live up to the promise of personalized medicine, revolutionizing the management of health in wellness and disease.” Dr. Wisniewski, who leads the team of biosensor developers, is the chief technology officer and co-founder of Profusa Inc., a San Francisco Bay Area-based life science company.

Continue reading “Injectable Body Sensors Take Personal Chemistry to a Cell Phone Closer to Reality” »

Self-organized criticality emerges in dynamical complex systems driven out of equilibrium and characterizes a wide range of classical phenomena in physics, geology, and biology. We report on a quantum coherence–controlled self-organized critical transition observed in the light localization behavior of a coherence-driven nanophotonic configuration. Our system is composed of a gain-enhanced plasmonic heterostructure controlled by a coherent drive, in which photons close to the stopped-light regime interact in the presence of the active nonlinearities, eventually synchronizing their dynamics. In this system, on the basis of analytical and corroborating full-wave Maxwell-Bloch computations, we observe quantum coherence–controlled self-organized criticality in the emergence of light localization arising from the synchronization of the photons. It is associated with two first-order phase transitions: one pertaining to the synchronization of the dynamics of the photons and the second pertaining to an inversionless lasing transition by the coherent drive. The so-attained light localization, which is robust to dissipation, fluctuations, and many-body interactions, exhibits scale-invariant power laws and absence of finely tuned control parameters. We also found that, in this nonequilibrium dynamical system, the effective critical “temperature” of the system drops to zero, whereupon one enters the quantum self-organized critical regime.

The self-organization of many nonequilibrium complex systems toward an “ordered” state is a profound concept in basic science, ranging from biochemistry to physics (2–4). Examples include the group movement of flocks of birds , motions of human crowds , neutrino oscillations in the early universe , and the formation of shapes (“morphogenesis”) in biological organisms (8, 9). An intriguing trait of this nonequilibrium, driven-dissipative systems (2, 3) is that their self-organization can lead them to a phase transition and to critical behavior—a phenomenon known as self-organized criticality (SOC) (10). Unlike equilibrium phase-transition phenomena, such as superconductivity or ferromagnetism, where an exogenous control parameter (for example, temperature or pressure) needs to be precisely tuned for the phase transition to occur, no such fine-tuning is needed in SOC systems (10–13): They can self-organize and reach their critical state even when driven far away from it.

https://www.rd.com/health/wellness/signs-body-is-aging-faster-than-you/

But it remains to be seen whether drug regulators will go along with a new way of making medicines. To do so, agencies like the U.S. Food and Drug Administration will need to rewrite their rules for validating the safety of medicines. Instead of signing off on the production facility and manufactured drug samples, regulators would have to validate that reactionware produces the desired medication. Cronin agrees it’s a hurdle. But he argues that future printed reactors could simply include a final module containing standard validation tests that produce a visual readout, much like a pregnancy test. “I think it’s manageable.”

Digitized chemistry on demand could also undermine drug counterfeiters.