Lifeboat Foundation

Circa 2021 First breakthrough in immortality of the eyes of rats using the inducing of pluripotent stem cells in the eye. Which will eventually lead to immortality of the human eye.

The retina is neural tissue located in the posterior part of the eye and is an extension of the central nervous system (CNS), which has limited regenerative potential once damaged¹. Therefore, to maintain homeostasis of the retinal microenvironment and protect itself from harmful stimuli, the retina has a unique structure consisting of inner and outer blood-retinal barriers (BRBs)^2,3,4. The outer BRB is mainly composed of retinal pigment epithelial (RPE) cells, which support photoreceptor cells, the primary neurons in the retina, and play a significant role in the pathogenesis of retinal degenerative disorders, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP)^5,6,7,8,9. These disorders are commonly characterized by the irreversible loss of photoreceptor cells and RPE cells, and the only fundamental treatment for these retinal degenerative disorders is replacement of damaged or atrophied cells^10,11,12. Thus, regenerative treatments, such as stem cell transplantation, are emerging as attractive options for targeting retinal degeneration that was previously considered untreatable¹³.

RP refers to a set of hereditary retinal degenerative disorders that initially involve photoreceptors and leads to subsequent RPE cell damage; it affects 1 in 4,000 individuals worldwide⁹. Due to its inherent nature, extensive genetic studies are ongoing, and more than 50 causal genes have been identified¹⁴. Among the causal genes, PDE6B is a gene that encodes rod cGMP-phosphodiesterase, which is a critical component of the biochemical light transduction pathway⁹. Although various molecular and genetic studies have identified the pathomechanisms of RP, attempts to restore vision in patients with RP have failed. To overcome this issue, preclinical stem cell-based studies involving transient dosing or permanent implantation of pluripotent stem cells are being conducted^10,11,15,16.

Continue reading “Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats” »

Life (as we know it) is based on carbon. Despite its ubiquity, this important element still holds plenty of secrets, on earth and in the heavens above us. For example, astrophysicists like Columbia’s Daniel Wolf Savin who study interstellar clouds want to understand how the chemicals, including carbon, swirling within these nebulous aggregations of gas and dust form the stars and planets that dot our universe and give rise to organic life.

Next big thing Haifei Zhan and colleagues reckon that carbon nanothreads have a future in energy storage. (Courtesy: Queensland University of Technology) Computational and theoretical studies of diamond-like carbon nanothreads suggest that…

Computational and theoretical studies of diamond-like carbon nanothreads suggest that they could provide an alternative to batteries by storing energy in a strained mechanical system. The team behind the research says that nanothread devices could power electronics and help with the shift towards renewable sources of energy.

The traditional go-to device for energy storage is the electrochemical battery, which predates even the widespread use of electricity. Despite centuries of technological progress and near ubiquitous use, batteries remain prone to the same inefficiencies and hazards as any device based on chemical reactions – sluggish reactions in the cold, the danger of explosion in the heat and the risk of toxic chemical leakages.

Continue reading “Diamond nanothreads could beat batteries for energy storage” »

An electrochemically powered artificial muscle made from twisted carbon nanotubes contracts more when driven faster thanks to a novel conductive polymer coating. Developed by Ray Baughman of the University of Texas at Dallas in the US and an international team, the device overcomes some of the limitations of previous artificial muscles, and could have applications in robotics, smart textiles and heart pumps.

Carbon nanotubes (CNTs) are rolled-up sheets of carbon with walls as thin as a single atom. When twisted together to form a yarn and placed in an electrolyte bath, CNTs expand and contract in response to electrochemical inputs, much like a natural muscle. In a typical set-up, a potential difference between the yarn and an electrode drives ions from the electrolyte into the yarn, causing the muscle to actuate.

While such CNT muscles are highly energy efficient and extremely strong – they can lift loads up to 100,000 times their own weight – they do have limitations. The main one is that they are bipolar, meaning that the direction of their movement switches whenever the potential drops to zero. This reduces the overall stroke of the actuator. Another drawback is that the muscle’s capacitance decreases when the potential is changed quickly, which also causes the stroke to decrease.

Researchers in the US, Poland and Korea have observed photon avalanching – a chain-reaction-like process in which the absorption of a single photon triggers the emission of many – in tiny crystals just 25–30 nm in diameter. This highly nonlinear phenomenon had previously only been seen in bulk materials, and team leader James Schuck says that replicating it in nanoparticles could lead to “revolutionary new applications” in imaging, sensing and light detection (Nature 589 230).

Photon avalanching involves a process known as upconversion, whereby the energy of the emitted photons is higher than the energy of the photons that triggered the avalanche. Materials based on lanthanides (chemical elements with atomic numbers between 57 and 71) can support this process in part because their internal atomic structure enables them to store energy for long periods of time. Even so, achieving photon avalanching in lanthanide systems is difficult because high concentrations of lanthanide ions are needed to keep the avalanche going, and the relatively large volume of material required has previously restricted applications.

In the latest work, Schuck and colleagues at Columbia University, together with collaborators at Lawrence Berkeley National Laboratory, the Polish Academy of Sciences and Sungkyunkwan University, observed photon avalanching in lanthanide nanocrystals after exciting them with a laser at near-infrared wavelengths of either 1,064 or 1450 nm. The crystals are based on sodium yttrium fluoride in which 8% of the yttrium ions have been replaced with thulium. This doping fraction is much higher than the 0.2–1% typically found in previous work on photon avalanching.

An artificial nose, which is combined with machine learning and built with a 16-channel sensor array was found to be able to authenticate up to 20 individuals with an average accuracy of more than 97%.

“These techniques rely on the physical uniqueness of each individual, but they are not foolproof. Physical characteristics can be copied, or even compromised by injury,” explains Chaiyanut Jirayupat, first author of the study. “Recently, human scent has been emerging as a new class of biometric authentication, essentially using your unique chemical composition to confirm who you are.”

The team turned to see if human breath could be used after finding that the skin does not produce a high enough concentration of volatile compounds for machines to detect.

Decades of research has led to a thorough understanding of the main protein players and the broad strokes of membrane fusion for synaptic transmission. Bernard Katz was awarded the 1970 Nobel Prize in Medicine in part for demonstrating that chemical synaptic transmission consists of a neurotransmitter-filled synaptic vesicle fusing with the plasma membrane at nerve endings and releasing its content into the opposing postsynaptic cell. And Rizo-Rey’s longtime collaborator, Thomas Südhof, won the Nobel Prize in Medicine in 2013 for his studies of the machinery that mediates neurotransmitter release (many with Rizo-Rey as a co-author).

But Rizo-Rey says his goal is to understand the specific physics of how the activation process of thought occurs in much more detail. “If I can understand that, winning the Nobel Prize would just be a small reward,” he said.

Recently, using the Frontera supercomputer at the Texas Advanced Computing Center (TACC), one of the most powerful systems in the world, Rizo-Rey has been exploring this process, creating a multi-million atom model of the proteins, the membranes, and their environment, and setting them in motion virtually to see what happens, a process known as molecular dynamics.

Artificial Intelligence is touching almost every aspect of our lives. It’s reasonable to expect AI influence will only increase in the future. One of many fields heavily influenced by AI is the military. Particularly in the development of Supersoldiers. The notion of super-soldiers enhanced with biotechnology and cybernetics was once only possible in the realm of science fiction. But it may not be too long before these concepts become a reality.

A new worldwide arms race is pitting countries against each other to be the first to successfully create real genetically modified super soldiers by using tools such as CRISPR. Understandably many of these human enhancement technologies raise health and safety questions and it is more likely these enhancements will first gain traction in countries that do not place as much weight on ethical concerns.

Continue reading “The Rise of Supersoldiers — How AI Changes Everything” »

The need to find alternative sources for fertilizer have become urgent as chemical fertilizer shortages from the Ukrainian war threaten countries globally.

A Chinese military analyst suggested countermeasures for the Starlink satellite system developed by Musk’s SpaceX – including ways to hack or destroy the service.

Continue reading “As chemical fertilizer shortages persist, peecycling — the process of recycling human urine — could increase the yield of nutrient-rich crops” »