Lifeboat Foundation

Brain-machine interfaces (BMIs) are devices that enable direct communication/translation between biological neuronal networks (e.g. a brain or a spine) and external machines. They are currently being used as a tool for fundamental neuroscience research and also for treating neurological disorders and for manipulating neuro-prosthetic devices. As remarkable as today’s BMIs are, however, the next generation BMIs will require new hardware and software with improved resolution and specificity in order to precisely monitor and control the activities of complex neuronal networks. In this talk, I will describe my group’s effort to develop new neuroelectronic devices enabled by silicon nanotechnology that can serve as high-precision, highly multiplexed interface to neuronal networks. I will then describe the promises, as well as potential pitfalls, of next generation BMIs. Hongkun Park is a Professor of Chemistry and Chemical Biology and a Professor of Physics at Harvard University. He is also an Institute Member of the Broad Institute of Harvard and MIT and a member of the Harvard Center for Brain Science and Harvard Quantum Optics Center. He serves as an associate editor of Nano Letters. His research interests lie in exploring solid-state photonic, optoelectronic, and plasmonic devices for quantum information processing as well as developing new nano-and microelectronic interfaces for living cells, cell networks, and organisms. Awards and honors that he received include the Ho-Am Foundation Prize in Science, NIH Director’s Pioneer Award, and the US Vannevar Bush Faculty Fellowship, the David and Lucile Packard Foundation Fellowship for Science and Engineering, the Alfred P. Sloan Research Fellowship, and the Camille Dreyfus Teacher-Scholar Award. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

As our devices get smaller and smaller, the use of molecules as the main components in electronic circuitry is becoming ever more critical. Over the past 10 years, researchers have been trying to use single molecules as conducting wires because of their small scale, distinct electronic characteristics, and high tunability. But in most molecular wires, as the length of the wire increases, the efficiency by which electrons are transmitted across the wire decreases exponentially. This limitation has made it especially challenging to build a long molecular wire—one that is much longer than a nanometer—that actually conducts electricity well.

Columbia researchers announced today that they have built a nanowire that is 2.6 nanometers long, shows an unusual increase in conductance as the wire length increases, and has quasi-metallic properties. Its excellent conductivity holds great promise for the field of molecular electronics, enabling electronic devices to become even tinier. The study is published today in Nature Chemistry.

Scientists at Tokyo Institute of Technology designed a new type of molecular wire doped with organometallic ruthenium to achieve unprecedentedly higher conductance than earlier molecular wires. The origin of high conductance in these wires is fundamentally different from similar molecular devices and suggests a potential strategy for developing highly conducting “doped” molecular wires.

Since their conception, researchers have tried to shrink electronic devices to unprecedented sizes, even to the point of fabricating them from a few molecules. Molecular wires are among the building blocks of such minuscule contraptions, and many researchers have been developing strategies to synthesize highly conductive, stable wires from carefully designed molecules.

A team of researchers from Tokyo Institute of Technology, including Yuya Tanaka, designed a novel molecular wire in the form of a metal electrode-molecule-metal electrode (MMM) junction including a polyyne, an organic chain-like molecule, “doped” with a ruthenium-based unit Ru(dppe)₂. The proposed design, featured in the cover of the Journal of the American Chemical Society, is based on engineering the energy levels of the conducting orbitals of the atoms of the wire, considering the characteristics of gold electrodes.

Researchers say ointment could become standard medication, but long path ahead; chemical ‘jams’ communication between bacteria at injury site, making healing easier.

Circa 2020

A little while ago, we covered the idea of using photovoltaic materials to drive enzymatic reactions in order to produce specific chemicals. The concept is being considered mostly because doing the same reaction in a cell is often horribly inefficient, because everything else in the cell is trying to regulate the enzymes, trying to use the products, trying to convert the byproducts into something toxic, or up to something even more annoying. But in many cases, these reactions rely on chemicals that are only made by cells, leaving some researchers to suspect it still might be easier to use living things in the end.

Everything we know, think and feel—everything!—comes from our brains. But consciousness, our private sense of inner awareness, remains a mystery. Brain activities—spiking of neuronal impulses, sloshing of neurochemicals—are not at all the same thing as sights, sounds, smells, emotions. How on earth can our inner experiences be explained in physical terms?

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It’s the first comprehensive study to look at the association between endocrine-disrupting chemicals, including PFAS, and rates of non-alcoholic fatty liver disease in kids.

How does the human brain work and how is it different from computers? If you think this is too complex to explain in a few minutes, you will be surprised. In this energetic and insightful talk, neuro-scientist Dr. Henning Beck gives insights into thought processes and tells you how you can create new ideas.

Dr. Henning Beck, neuroscientist and author, supports businesses to use brain-based approaches in order to develop innovative and efficient workflows. He studied biochemistry in Tübingen from 2003 to 2008. After his diploma thesis, he started his research at the Hertie Institute for Clinical Brain Research and intensified his work at the Institute of Physiological Chemistry at the University of Ulm. Supported by a PhD scholarship granted by the Hertie Foundation he did his doctorate at the Graduate School of Cellular & Molecular Neuroscience in Tübingen. He expanded his scientific expertise by an International Diploma in Project Management at the University of California, Berkeley in 2013. Until 2014, he worked for start-ups in the San Francisco Bay Area to develop creative workspace designs and advanced communication styles based on neuroscientific principles.

Continue reading “What is a Thought? How the Brain Creates New Ideas | Henning Beck | TEDxHHL” »

As you’re reading this sentence, the cells in your brain, called neurons, are sending rapid-fire electrical signals between each other, transmitting information. They’re doing so via tiny, specialized junctions between them called synapses.

There are many different types of synapses that form between neurons, including “excitatory” or “inhibitory,” and the exact mechanisms by which these structures are generated remain unclear to scientists. A Colorado State University biochemistry lab has uncovered a major insight into this question by showing that the types of chemicals released from synapses ultimately guide which kinds of synapses form between neurons.

Soham Chanda, assistant professor in the Department of Biochemistry and Molecular Biology, led the study published in Nature Communications that demonstrates the possibility of changing the identity of synapses between neurons, both in vitro and in vivo, through enzymatic means. The other senior scientists who contributed to the project were Thomas Südhof of Stanford University and Matthew Xu-Friedman of the University at Buffalo.