Lifeboat Foundation

Four billion years ago, the Earth looked very different than it does today, devoid of life and covered by a vast ocean. Over the course of millions of years, in that primordial soup, life emerged. Researchers have long theorized how molecules came together to spark this transition. Now, scientists at Scripps Research have discovered a new set of chemical reactions that use cyanide, ammonia and carbon dioxide—all thought to be common on the early earth—to generate amino acids and nucleic acids, the building blocks of proteins and DNA.

“We’ve come up with a new paradigm to explain this shift from prebiotic to biotic chemistry,” says Ramanarayanan Krishnamurthy, Ph.D., an associate professor of chemistry at Scripps Research, and lead author of the new paper, published July 28, 2022 in the journal Nature Chemistry. “We think the kind of reactions we’ve described are probably what could have happened on early earth.”

In addition to giving researchers insight into the chemistry of the early earth, the newly discovered chemical reactions are also useful in certain manufacturing processes, such as the generation of custom labeled biomolecules from inexpensive starting materials.

Perovskite solar cells (PSCs) are promising solar technologies. Although low-cost wet processing has shown advantages in small-area PSC fabrication, the preparation of uniform charge transport layers with thickness of several nanometers from solution for meter-sized large area products is still challenging.

Recently, a research group led by Prof. LIU Shengzhong from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) has developed a facile surface redox engineering (SRE) strategy for vacuum-deposited NiO x to match the slot-die-coated perovskite, and fabricated high-performance large-area perovskite submodules.

This work was published in Joule (“Surface redox engineering of vacuum-deposited NiO x for top-performance perovskite solar cells and modules”).

A single chemical could be responsible for whether people go bald or not, a new study has found.

In the UK, approximately two thirds of men will face male pattern baldness. The study says the discovery of the chemical could “not only treat baldness, but ultimately speed wound healing”.

Researchers at the University of California, Riverside, found that a sole chemical is responsible for hair follicles dividing and dying.

The platform, still in the early development phase, is called Druglike, according to a press release that circulated on July 25. Its goals are ostensibly lofty, but the details are extremely sketchy, and Shkreli’s intentions have already drawn skepticism. It’s also unclear whether the enterprise will run Shkreli afoul of his lifetime ban from the pharmaceutical industry, which stemmed from the abrupt and callous 4,000 percent price hike of a life-saving drug that made him infamous.

Shkreli, who is named as a cofounder of Druglike, says the platform aims to make early-stage drug discovery more affordable and accessible. “Druglike will remove barriers to early-stage drug discovery, increase innovation and allow a broader group of contributors to share the rewards,” Shkreli said in the press release. “Underserved and underfunded communities, such as those focused on rare diseases or in developing markets, will also benefit from access to these tools.”

Generally, early-stage drug development can sometimes involve virtual screens to identify potential drug candidates. In these cases, pharmaceutical scientists first identify a “target”—a specific compound or protein that plays a critical role in developing a disease or condition. Then researchers look for compounds or small molecules that could interfere with that target, sometimes binding or “docking” directly to the target in a way that keeps it from functioning. This can be done in physical labs using massive libraries of compounds in high-throughput chemical screens. But it can also be done virtually, using specialized software and a lot of computing power, which can be resource-intensive.

A single chemical is key to controlling when hair follicle cells divide, and when they die. This discovery could not only treat baldness, but ultimately speed wound healing because follicles are a source of stem cells.

The Virus Zoo is my latest educational blog post! I’ve written up ~1 page ‘cheat sheets’ on the molecular biology of specific viruses. I cover genome, structure, and life cycle. So far, my zoo includes adeno-associated virus (AAV), adenovirus, and herpes simplex virus 1 (HSV-1). However, I plan to add more viruses as time goes on! Some others I would like to incorporate later are coronavirus, HIV, anellovirus, lentivirus, ebolavirus, and MS2 bacteriophage. Feel free to suggest other interesting viruses in the comments! All images were created by me. #virology #molecularbiology #biotechnology #genetherapy #virus #biochemistry #genetics

Genome and Structure:

AAV genomes are about 4.7 kb in length and are composed of ssDNA. Inverted terminal repeats (ITRs) form hairpin structures at ends of the genome. These ITR structures are important for AAV genomic packaging and replication. Rep genes (encoded via overlapping reading frames) include Rep78, Rep68, Rep52, Rep40.¹ These proteins facilitate replication of the viral genome. As a Dependoparvovirus, additional helper functions from adenovirus (or certain other viruses) are needed for AAVs to replicate.

Continue reading “The Virus Zoo: A Quick Primer on Molecular Virology” »

As more drivers adopt plug-in hybrid and electric vehicles, the demand for lithium-ion batteries will continue to explode over the next decade. But processes for extracting lithium can be time-consuming and chemical-intensive, and traditional sources—including brine and hard rock—could ultimately be depleted.

Scientists and engineers are now looking to unconventional water sources, including oil-and gas-produced water, geothermal brines, and rejected brines from seawater desalination. But how much lithium lies within these sources, and how to best extract it, remains an open question.

Asst. Prof. Chong Liu’s team now has the answer. By analyzing more than 122,000 unconventional water sources, she and her team discovered that there is, in fact, enough lithium within these sources to make it worthwhile to extract.

New research from Binghamton University, State University of New York offers a second life for CDs: Turn them into flexible biosensors that are inexpensive and easy to manufacture.

In a paper published this month in Nature Communications, Matthew Brown, Ph.D. ‘22, and Assistant Professor Ahyeon Koh from the Department of Biomedical Engineering show how a gold CD’s thin metallic layer can be separated from the rigid plastic and fashioned into sensors to monitor electrical activity in human hearts and muscles as well as lactate, glucose, pH and oxygen levels. The sensors can communicate with a smartphone via Bluetooth.

The fabrication is completed in 20 to 30 minutes without releasing toxic chemicals or needing expensive equipment, and it costs about $1.50 per device. According to the paper, “this sustainable approach for upcycling electronic waste provides an advantageous research-based waste stream that does not require cutting-edge microfabrication facilities, expensive materials or high-caliber engineering skills.”

Circa 2016

Penn State scientists made a coating that allows conventional textiles used in everyday clothing to patch themselves up. Derived from squid ring teeth, the coating can turn virtually any fabric into a self-healing one. Simply adding water is enough to kick start the repairing process.

Continue reading “Self-healing textiles means you don’t have to throw away your torn jeans — just add water” »