Lifeboat Foundation

A universal therapy that targets mis-folded proteins is a very significant step forward if clinical trials in humans translate from animals. Obviously there is more work to be done but it this is the kind of technology we need in order to intervene against biological aging.

It is not hard to see that a therapy like this followed up by another that regenerates the brain eg, the Conboy Lab work by promoting neurogenesis could be a way to repair and restore the brain to healthy function.

A drug that breaks up different types of brain plaque shows promising results in animals and could prevent Alzheimer’s and Parkinson’s disease.

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You may remember neuroscientist Miguel Nicolelis — he built the brain-controlled exoskeleton that allowed a paralyzed man to kick the first ball of the 2014 World Cup. What’s he working on now? Building ways for two minds (rats and monkeys, for now) to send messages brain to brain. Watch to the end for an experiment that, as he says, will go to “the limit of your imagination.”

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Research on a cell signalling pathway common to mammals has now uncovered a signalling pathway and specific protein, which might act as a regulator in regeneration.

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Two-hit model of non-alcoholic fatty liver disease (credit: ILSI Europe)

In an open-access paper in the British Journal of Nutrition, a coalition of 17 experts explain how elevated unresolved chronic inflammation is involved a range of chronic diseases, and how nutrition influences inflammatory processes and helps reduce chronic risk of diseases.

According to the authors, “the nutrition status of the individual with for example a deficiency or excess of certain micronutrients (e.g. folate, vitamin B12, vitamin B6, vitamin 1, vitamin E, zinc) may lead to an ineffective or excessive inflammatory response.

Continue reading “Controlling inflammation to reduce chronic disease risk” »

As 3-D printing gains steam and moves beyond plastics, it could be applied to many other industries, revolutionising medicine on the way.

An Ohio based pharmaceutical company Aprecia has now developed a 3-D printing technology which creates a more porous pill structure — allowing higher dose pills to dissolve quicker and making them easier to swallow for some patients. The same technology also allows precise doses to be layered in the same structure. A UCL team have also developed a technique for printing different shapes, which affects drug release.

“For the last 50 years, we have manufactured tablets in factories and shipped them to hospitals, for the first time, this process means we can produce tablets much closer to the patient.”

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Baidu’s AskADoctor initiative is an ambitious project that recently emerged from Baidu’s deep learning division. We’ve gotta say, initial impressions seem very promising.

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Although inflammation has rather a bad reputation, it is a vital process which allows us to effectively fight off infection. Like many things however, there appears to be a balancing act, and when inflammation becomes maladaptive and persistent — it does more harm than good.

It seems that in the process of destroying adversaries, immune responses can create collateral damage which can set the stage for later cancerous developments.

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“The undisputed queen of personalized prosthetics.”

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While exploring which biological processes might predict successful in centenarians, a team from Newcastle and Tokyo have identified two prominent factors that facilitate health longevity — low level inflammation and telomere length.

“Centenarians and supercentenarians are different — put simply, they age slower. They can ward off diseases for much longer than the general population.”

After measuring a number of health markers in 1,554 people including: those over 105, between 100 and 105 and a group near their 100th birthday along with their offspring, these two elements emerged as consistent longevity predictors.

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