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Category: biotech/medical – Page 1,133

A new drug-resistant fungus is spreading in hospitals. Is it ‘The Last of Us’ in real life?

“Clinical cases of infections caused by C. auris almost doubled in 2021, according to research published this month in the Annals of Internal Medicine. And the number of cases resistant to echinocandins, the first-line treatment for C. auris infections, tripled. While the fungus generally isn’t a threat for healthy people, it can be dangerous for those with weakened or compromised immune systems, and people using feeding tubes or catheters—in other words, a large proportion of patients in hospitals. The fungus can cause a bloodstream infection whose symptoms include fever, chills, sweats, and low blood pressure. It’s still rare in the U.S., but roughly one in three patients with an invasive infection will die from it; the fungus poses an “urgent threat,” according to the US Centers for Disease Control and Prevention.”

Here’s a scenario that may sound familiar to fans of the postapocalyptic TV drama ‘The Last of Us’: a hard-to-kill fungus is beginning to spread among—and infect—vulnerable populations. Only this time, it’s real.

This Massive Meatball Was Made With Woolly Mammoth DNA

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In a sense, the extinct woolly mammoth has returned —as a meatball. On Tuesday, an Australian cultured meat start-up revealed a sphere of lab-grown meat, produced with a DNA sequence from the elephant-like mammal.

But you won’t find this product in grocery stores; the creation is not meant to be eaten, at least for now. Instead, the “mammoth meatball” aims to highlight the environmental impacts of standard agricultural practices and present cultured meat as a viable option for food production down the line.

“We wanted to get people excited about the future of food being different to potentially what we had before,” Tim Noakesmith, a co-founder of Vow, the company behind the meatball, tells Mike Corder of the Associated Press (AP). “We thought the mammoth would be a conversation starter. … What we wanted to do was see if we could create something that was a symbol of a more exciting future that’s not only better for us, but also better for the planet.”

A Disease Reversal Therapy That No Body Try Before

Previously Fahy has reported as much as a 15 year epigenetic clock reset. Again though, this won’t get you beyond your maximum natural limit, but younger and healthier now leads to the next bridge.

Dr Greg Fahy talks about the thymus magic. What are the out of expectation benefits of reprogramming our thymus(Not TRIIM or TRIIM-X) in this short clip.

Gregory M. Fahy is a cryobiologist and biogerontologist, and is also Vice President and Chief Scientific Officer at Twenty-First Century Medicine, Inc. Fahy is the world’s foremost expert in organ cryopreservation by vitrification. Fahy introduced the modern successful approach to vitrification for cryopreservation in cryobiology and he is widely credited, along with William F. Rall, for introducing vitrification into the field of reproductive biology.

Fahy is also a well-known biogerontologist and is the originator and Editor-in-Chief of The Future of Aging: Pathways to Human Life Extension, a multi-authored book on the future of biogerontology. He currently serves on the editorial boards of Rejuvenation Research and the Open Geriatric Medicine Journal and served for 16 years as a Director of the American Aging Association and for 6 years as the editor of AGE News, the organization’s newsletter.

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Serine + Vitamin B6: The Best Way To Reduce Homocysteine? (Also, Homocysteine Activates mTORC1)

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Alzheimer’s May Not Actually Be a Brain Disease, Expert Says

The pursuit of a cure for Alzheimer’s disease is becoming an increasingly competitive and contentious quest with recent years witnessing several important controversies.

In July 2022, Science magazine reported that a key 2006 research paper, published in the prestigious journal Nature, which identified a subtype of brain protein called beta-amyloid as the cause of Alzheimer’s, may have been based on fabricated data.

One year earlier, in June 2021, the US Food and Drug Administration had approved aducanumab, an antibody-targeting beta-amyloid, as a treatment for Alzheimer’s, even though the data supporting its use were incomplete and contradictory.

Predicting neuroblastoma outcomes with molecular evolution

A research team led by the German Cancer Research Center in Heidelberg, Germany, has discovered that the genetic sequence of a tumor can be read like a molecular clock, traced back to its most recent common ancestor cell. Extracting the duration of tumor evolution can give an accurate predictor of neuroblastoma outcomes.

In a paper published in Nature Genetics titled “Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome,” the team details the steps they took in identifying a genomic clock tested against a sequenced population combined with analysis and mathematical modeling, to identify evolution markers, traceability and a likely origin point of infant neuroblastomas.

Cancer cells start out life as heroic healthy tissues, with the sort of all for one, one for all, throw yourself on a grenade to save your mates–type attitude that is taking place throughout the body every day. At some point, something goes wrong, and a good cell goes bad.

New IVF method: More expensive, not more effective

The use of time-lapse monitoring in IVF does not result in more pregnancies or shorten the time it takes to get pregnant. This new method, which promises to “identify the most viable embryos,” is more expensive than the classic approach. Research from Amsterdam UMC, published today in The Lancet, shows that time-lapse monitoring does not improve clinical results.

Patients undergoing an IVF treatment often have several usable embryos. The laboratory then makes a choice as to which embryo will be transferred into the uterus. Crucial to this decision is the cell division pattern in the first three to five days of embryo development. In order to observe this, embryos must be removed from the incubator daily to be checked under a microscope. In time-lapse incubators, however, built-in cameras record the development of each embryo. This way embryos no longer need to be removed from the stable environment of the incubator and a computer algorithm calculates which embryo has shown the most optimal growth pattern.

More and more IVF centers, across the world, use time-lapse for the evaluation and selection of embryos. Prospective parents are often promised that time-lapse monitoring will increase their chance of becoming pregnant. Despite frequent use of this relatively expensive method, there are hardly any large clinical studies evaluating the added value of time-lapse monitoring for IVF treatments.

First single molecule microscopic visualization of the full-length human BRCA2 protein binding to DNA

Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.

Mutations in the breast cancer susceptibility gene, BRCA2, can significantly increase an individual’s lifetime risk of developing cancer. Approximately one in every 400 people carry a BRCA gene mutation accounting for a significant proportion of cancer that is heritable. The study was published on March 28 in the Proceedings of the National Academy of Sciences.

“If you carry a BRCA mutation, you have this incredibly high risk for breast and , and also for men, prostate and ,” said Yale Cancer Center member and co-author of the paper, Ryan Jensen, Ph.D., who is also an associate professor of therapeutic Radiology at Yale School of Medicine.

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