Lifeboat Foundation

Many people associate aging with a decline in cognitive function, health issues, and reduced activity. Uncovering mental processes that can boost the well-being of the older adults could be highly beneficial, as it could help to devise more effective activities aimed at improving their quality of life.

Researchers at University of Brescia and the Catholic University of the Sacred Heart recently carried out a study investigating the contribution of creativity and humor to the well-being of the elderly. Their findings, published in Neuroscience Letters, show that these two distinct human experiences share common psychological and neurobiological processes that promote well-being in older adults.

“Our recent study belongs to a line of research aimed at investigating the cognitive resources which are still available to elderly people and at understanding how such resources can support well-being,” Alessandro Antonietti, co-author of the paper, told Medical Xpress.

Yale researchers are using chemical “chameleons” to sneak up on drug-resistant brain tumors.

A Yale Cancer Center team has synthesized a compound, KL-50, that they say selectively targets drug-resistant glioblastomas while leaving healthy tissue alone.

Yale scientists say KL-50, their lead “chameleon” compound, effectively targets tumors without harming healthy surrounding tissue.

Continue reading “This well-timed ‘chameleon’ sneaks up on drug-resistant brain cancers” »

Longevity equals crazy here. I did leave a comment.

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A new study used machine learning to predict potential new antibiotics in the global microbiome, which study authors say marks a significant advance in the use of artificial intelligence in antibiotic resistance research…

For this study, the researchers collected genomes and meta-genomes stored in publicly available databases and looked for DNA snippets that could have antimicrobial activity. To validate those predictions, they used chemistry to synthesize 100 of those molecules in the laboratory and then test them to determine if they could actually kill bacteria, including ‘some of the most dangerous pathogens in our society’, de la Fuente said.

🧬❤️👩‍🔬 https://www.news-medical.net/news/20240609/New-study-reveals…al-role-in

In a recent study published in the journal Nature Medicine, a team of researchers in China conducted a prospective analysis of metabolic multimorbidity clusters based on 21 metabolic parameters to investigate gut microbiome signatures associated with metabolism and age to better understand the relationship between metabolism, age, and the long term risk of cardiovascular disease.

Study: Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk. Image Credit: Kateryna Kon / Shutterstock.

Continue reading “New study reveals gut microbiome’s critical role in aging and heart disease” »

Year 2022 This can lead to even greater understanding of the human brain with organiods in mice.

Neuron al organoids derived from human induced pluripotent stem cells can be transplanted and integrated into the rodent cortex for the study of brain development and function. Here the authors demonstrate use of transparent graphene microelectrodes and two photon imaging for longitudinal, multimodal monitoring of functional connectivity between human iPSC derived neuronal organoids and the mouse cortex.

For all the good antibiotics do for the world, one of the biggest downsides to their use is the way they indiscriminately kill both the ‘good’ and the ‘bad’

A single course of this life-saving medicine can not only destroy disease-causing invaders in the human body; it can also have an “immense” impact on the gut and its resident collection of microbes.

This impact can sometimes lead to an overgrowth of certain bacteria or fungi. For instance, women have up to a 30 percent chance of developing a yeast infection after antibiotic treatment.

Researchers at Columbia University College of Dental Medicine have developed an exosome-based platform, “safeEXO-Cas,” that significantly enhances the delivery of CRISPR/Cas9 genome editing components to specific cells and tissues.

New details on how certain gluten-derived molecules trigger leaky gut syndrome in affected individuals. Celiac disease is a chronic autoimmune condition that occurs in around one per cent of the world’s population. It is triggered by the consumption of gluten proteins from wheat, barley, rye and some oats. A gluten-free diet protects celiac patients from severe intestinal damage. Together with colleagues, chemist Dr Veronica Dodero from Bielefeld University was able to determine new details on how certain gluten-derived molecules trigger leaky gut syndrome in celiac disease.