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Archive for the ‘biological’ category: Page 9

Jun 26, 2024

Synaptic Characteristic of Hafnia-Based Ferroelectric Tunnel Junction Device for Neuromorphic Computing Application

Posted by in categories: biological, robotics/AI

Owing to the 4th Industrial Revolution, the amount of unstructured data, such as voice and video data, is rapidly increasing. Brain-inspired neuromorphic computing is a new computing method that can efficiently and parallelly process rapidly increasing data. Among artificial neural networks that mimic the structure of the brain, the spiking neural network (SNN) is a network that imitates the information-processing method of biological neural networks. Recently, memristors have attracted attention as synaptic devices for neuromorphic computing systems. Among them, the ferroelectric doped-HfO2-based ferroelectric tunnel junction (FTJ) is considered as a strong candidate for synaptic devices due to its advantages, such as complementary metal-oxide-semiconductor device/process compatibility, a simple two-terminal structure, and low power consumption. However, research on the spiking operations of FTJ devices for SNN applications is lacking. In this study, the implementation of long-term depression and potentiation as the spike timing-dependent plasticity (STDP) rule in the FTJ device was successful. Based on the measured data, a CrossSim simulator was used to simulate the classification of handwriting images. With a high accuracy of 95.79% for the Mixed National Institute of Standards and Technology (MNIST) dataset, the simulation results demonstrate that our device is capable of differentiating between handwritten images. This suggests that our FTJ device can be used as a synaptic device for implementing an SNN.

Keywords: FTJ; SNN; STDP; neuromorphic computing; synaptic devices.

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Jun 25, 2024

The genetic engineering Swiss army knife

Posted by in categories: bioengineering, biological, genetics

In molecular biology, few molecules have had as profound an impact as Cas9. Madeleine King, Kayla Perry, Mitchell McAndrew and Audrone Lapinaite discuss how this multifunctional molecular tool of genetic engineering is revolutionizing multiple fields.

Jun 25, 2024

| Proceedings of the National Academy of Sciences

Posted by in categories: biological, climatology, physics, robotics/AI, sustainability

Physics meets machine learning.


The Progress and Promise for Science in Indonesia Regional Special Feature focuses on biodiversity and climate change, highlighting research based on the unique geology and biology of a nation comprising more than 17,600 islands, containing about 10 percent of the world’s remaining tropical forests, and home to over 300,000 species of wildlife.

Jun 25, 2024

Unravelling the operation of organic artificial neurons for neuromorphic bioelectronics

Posted by in categories: biological, chemistry, mapping, robotics/AI

Organic electrochemical artificial neurons (OANs) are the latest entry of building blocks, with a few different approaches for circuit realization. OANs possess the remarkable capability to realistically mimic biological phenomena by responding to key biological information carriers, including alkaline ions, noise in the electrolyte, and biological conditions. An organic artificial neuron with a cascade-like topology made of OECT inverters has shown basic (regular) firing behavior and firing frequency that is responsive to the concentration of ionic species (Na+, K+) of the host liquid electrolyte33. An organic artificial neuron consisting of a non-linear building block that displays S-shape negative differential resistance (S-NDR) has also been recently demonstrated34. Due to the realization of the non-linear circuit theory with OECTs and the sharp threshold for oscillations, this artificial neuron displays biorealistic firing properties and neuronal excitability that can be found in the biological domain such as input voltage-induced regular and irregular firing, ion and neurotransmitter-induced excitability and ion-specific oscillations. Biohybrid devices comprising artificial neurons and biological membranes have also shown to operate synergistically, with membrane impedance state modulating the firing properties of the biohybrid in situ. More recently, a circuit leveraging the non-linear properties of antiambipolar OMIECs, which exhibit negative differential transconductance, has been realized35. These neurons show biorealistic properties such as various firing modes and responsivity to biologically relevant ions and neurotransmitters. With this neuron, ex-situ electrical stimulation has been shown in a living biological model. Therefore, the class of OANs perfectly complements the broad range of features already demonstrated by solid-state spiking circuits (Supplementary Table 1), offering opportunities for both hybrid interfacing between these technologies and new developments in neuromorphic bioelectronics.

Despite the promising recent realizations of organic artificial neurons, all approaches still remain in the qualitative demonstration domain and a rigorous investigation of circuit operation is still missing. Indeed, quantitative models exist only for inorganic, solid-state artificial neurons without the inclusion of physical soft-matter parameters and the biological wetware (i.e., aqueous electrolytes, alkaline ions, biomembranes)36,37. This gap in knowledge significantly impedes the simulation of larger-scale functional circuits, and therefore the design and development of integrated organic neuromorphic electronics, biohybrids, OAN-based neural networks, and intelligent bioelectronics.

In this work, we unravel the operation of organic artificial neurons that display non-linear phenomena such as S-shape negative differential resistance (S-NDR). By combining experiments, numerical simulations of non-linear iontronic circuits, and newly developed analytical expressions, we investigate, reproduce, rationalize, and design the wide biorealistic repertoire of organic electrochemical artificial neurons including their firing properties, neuronal excitability, wetware operation, and biohybrid formation. The OAN operation is efficiently rationalized to include how neuronal dynamics are probed by biochemical stimuli in the electrolyte medium. The OAN behavior is also extended on the biohybrid formation, with a solid rationale of the in situ interaction of OANs with biomembranes. Non-linear simulations of OANs are rooted in a physics-based framework, considering ion type, ion concentration, organic mixed ionic–electronic parameters, and biomembrane properties. The derived analytical expressions establish a direct link between OAN spiking features and its physical parameters and therefore provide a mapping between neuronal behavior and materials/device parameters. The proposed approach open opportunities for the design and engineering of advanced biorealistic OAN systems, establishing essential knowledge and tools for the development of neuromorphic bioelectronics, in-liquid neural networks, biohybrids, and biorobotics.

Jun 25, 2024

An artificial visual neuron with multiplexed rate and time-to-first-spike coding

Posted by in categories: biological, robotics/AI, transportation

Human visual neurons rely on event-driven, energy-efficient spikes for communication, while silicon image sensors do not. The energy-budget mismatch between biological systems and machine vision technology has inspired the development of artificial visual neurons for use in spiking neural network (SNN). However, the lack of multiplexed data coding schemes reduces the ability of artificial visual neurons in SNN to emulate the visual perception ability of biological systems. Here, we present an artificial visual spiking neuron that enables rate and temporal fusion (RTF) coding of external visual information. The artificial neuron can code visual information at different spiking frequencies (rate coding) and enables precise and energy-efficient time-to-first-spike (TTFS) coding. This multiplexed sensory coding scheme could improve the computing capability and efficacy of artificial visual neurons. A hardware-based SNN with the RTF coding scheme exhibits good consistency with real-world ground truth data and achieves highly accurate steering and speed predictions for self-driving vehicles in complex conditions. The multiplexed RTF coding scheme demonstrates the feasibility of developing highly efficient spike-based neuromorphic hardware.

Jun 25, 2024

Neuromorphic nanoelectronic materials

Posted by in categories: biological, chemistry, nanotechnology, quantum physics, robotics/AI

Memristive and nanoionic devices have recently emerged as leading candidates for neuromorphic computing architectures. While top-down fabrication based on conventional bulk materials has enabled many early neuromorphic devices and circuits, bottom-up approaches based on low-dimensional nanomaterials have shown novel device functionality that often better mimics a biological neuron. In addition, the chemical, structural and compositional tunability of low-dimensional nanomaterials coupled with the permutational flexibility enabled by van der Waals heterostructures offers significant opportunities for artificial neural networks. In this Review, we present a critical survey of emerging neuromorphic devices and architectures enabled by quantum dots, metal nanoparticles, polymers, nanotubes, nanowires, two-dimensional layered materials and van der Waals heterojunctions with a particular emphasis on bio-inspired device responses that are uniquely enabled by low-dimensional topology, quantum confinement and interfaces. We also provide a forward-looking perspective on the opportunities and challenges of neuromorphic nanoelectronic materials in comparison with more mature technologies based on traditional bulk electronic materials.

Jun 23, 2024

Feeling the Beat: Music’s Global Language of Emotion

Posted by in categories: biological, media & arts

A study shows music evokes consistent emotional and physical responses globally, driven by inherent biological mechanisms, not culture. Music influences feelings in different body parts based on the emotion it conveys, supporting its role in social bonding.

New research shows that music evokes similar emotions and bodily sensations around the world. The study, by the Turku PET Centre in Finland, was published in the Proceedings of the National Academy of Sciences.

Music can be felt directly in the body. When we hear our favorite catchy song, we are overcome with the urge to move to the music. Music can activate our autonomic nervous system and even cause shivers down the spine. A new study from the Turku PET Centre in Finland shows how emotional music evokes similar bodily sensations across cultures.

Jun 22, 2024

Advances in nanoscale force measurement opens doors to unprecedented biological insights

Posted by in categories: biological, nanotechnology

New research has revealed a new way to measure incredibly minute forces at the nanoscale in water, pushing the boundaries of what scientists know about the microscopic world.

Jun 21, 2024

Why Does Biological Evolution Work? A Minimal Model for Biological Evolution and Other Adaptive Processes

Posted by in categories: biological, computing, space

Stephen Wolfram explores simple models of biological organisms as computational systems. A study of progressive development, multiway graphs of all possible paths and the need for narrowing the framework space.

Jun 18, 2024

Decoding Mental Health With Advanced Brain Gene Maps

Posted by in categories: biological, genetics, health, mapping, neuroscience

Groundbreaking maps reveal the complex gene regulation in brains with and without mental disorders, enhancing the understanding of mental illnesses and potential treatments.

A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain’s biological pathways and cellular functions. The research, supported by the National Institutes of Health (NIH), used postmortem brain tissue from over 2,500 donors to map gene regulation networks across different stages of brain development and multiple brain-related disorders.

“These groundbreaking findings advance our understanding of where, how, and when genetic risk contributes to mental disorders such as schizophrenia, post-traumatic stress disorder, and depression,” said Joshua A. Gordon, M.D., Ph.D., director of NIH’s National Institute of Mental Health (NIMH). “Moreover, the critical resources, shared freely, will help researchers pinpoint genetic variants that are likely to play a causal role in mental illnesses and identify potential molecular targets for new therapeutics.”

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