Thor Balkhed/Linköping University.
Made of collagen protein from pig’s skin, the implant resembles the human cornea and is more than a pipe dream for an estimated number of 12.7 million people around the world who are blind due to their diseased corneas. The implant is a promising alternative to the transplantation of donated human corneas, which are scarce in under-developed and developing countries, where the need for them is greatest.
A pair of UCLA bioengineers and a former postdoctoral scholar have developed a new class of bionic 3D camera systems that can mimic flies’ multiview vision and bats’ natural sonar sensing, resulting in multidimensional imaging with extraordinary depth range that can also scan through blind spots.
Powered by computational image processing, the camera can decipher the size and shape of objects hidden around corners or behind other items. The technology could be incorporated into autonomous vehicles or medical imaging tools with sensing capabilities far beyond what is considered state of the art today. This research has been published in Nature Communications.
In the dark, bats can visualize a vibrant picture of their surroundings by using a form of echolocation, or sonar. Their high-frequency squeaks bounce off their surroundings and are picked back up by their ears. The minuscule differences in how long it takes for the echo to reach the nocturnal animals and the intensity of the sound tell them in real time where things are, what’s in the way and the proximity of potential prey.
Researchers and entrepreneurs have developed an implant made of collagen protein from pig’s skin, which resembles the human cornea. In a pilot study, the implant restored vision to 20 people with diseased corneas, most of whom were blind prior to receiving the implant.
The study jointly led by researchers at Linköping University (LiU) and LinkoCare Life Sciences AB has been published in Nature Biotechnology. The promising results bring hope to those suffering from corneal blindness and low vision by providing a bioengineered implant as an alternative to the transplantation of donated human corneas, which are scarce in countries where the need for them is greatest.
Motors are ubiquitous in our everyday lives — from cars to washing machines, even if we rarely notice them. A futuristic scientific field is working on the development tiny motors that could power a network of nanomachines and replace some of the power sources we currently use in electronic devices.
Researchers from the Cockrell School of Engineering at The University of Texas at Austin created the first ever solid-state optical nanomotor. All previous iterations of these light-driven motors reside in a solution of some sort, which limited their potential for the majority of real-world applications. This new research was published recently in the journal ACS Nano.
“Life started in the water and eventually moved on land,” said Yuebing Zheng, an associate professor in the Walker Department of Mechanical Engineering. “We’ve made these micro nanomotors that have always lived in solution work on land, in a solid state.”
Stem cells that might save a baby’s life and be utilized to treat illnesses like lymphoma and leukemia are found in the umbilical cord of newborns. Because of this, many new parents decide to preserve (“bank”) the umbilical cord blood’s abundant stem cells for their child. However, since gestational diabetes destroys stem cells and makes them useless, parents are not given this choice in the 6 to 15% of pregnancies who are impacted by the illness.
In a study that will be published in the journal Communications Biology, bioengineers at the University of Notre Dame have now shown that a new approach may heal the injured stem cells and allow them to once again grow new tissues.
Specially-created nanoparticles are the key component of this new strategy. Each spherical nanoparticle may store medication and deliver it specifically to the stem cells by attaching it to the surface of the cells. These nanoparticles are about 150 nanometers in diameter or about a fourth of the size of a red blood cell. The particles deliver the medication gradually as a result of their unique tuning, which makes them very effective even at very low dosages.
A Purdue University chemical engineer has improved upon traditional methods to produce off-the-shelf human immune cells that show strong antitumor activity, according to a paper published in the peer-reviewed journal Cell Reports.
Xiaoping Bao, a Purdue University assistant professor from the Davidson School of Chemical Engineering, said CAR-neutrophils, or chimeric antigen receptor neutrophils, and engraftable HSCs, or hematopoietic stem cells, are effective types of therapies for blood diseases and cancer. Neutrophils are the most abundant white cell blood type and effectively cross physiological barriers to infiltrate solid tumors. HSCs are specific progenitor cells that will replenish all blood lineages, including neutrophils, throughout life.
“These cells are not readily available for broad clinical or research use because of the difficulty to expand ex vivo to a sufficient number required for infusion after isolation from donors,” Bao said. “Primary neutrophils especially are resistant to genetic modification and have a short half-life.”
Within minutes of the final heartbeat, a cascade of biochemical events triggered by a lack of blood flow, oxygen, and nutrients begins to destroy a body’s cells and organs. But a team of Yale scientists has found that massive and permanent cellular failure doesn’t have to happen so quickly.
The researchers stressed that additional studies are necessary to understand the apparently restored motor functions in the animals, and that rigorous ethical review from other scientists and bioethicists is required.
The experimental protocols for the latest study were approved by Yale’s Institutional Animal Care and Use Committee and guided by an external advisory and ethics committee.
The OrganEx technology could eventually have several potential applications, the authors said. For instance, it could extend the life of organs in human patients and expand the availability of donor organs for transplant. It might also be able to help treat organs or tissue damaged by ischemia during heart attacks or strokes.
Got a protein? This AI will tell you what it looks like.
AlphaFold was recognized by the journal Science as 2021’s Breakthrough of the Year, beating out candidates like Covid-19 antiviral pills and the application of CRISPR gene editing in the human body. One expert even wondered if AlphaFold would become the first AI to win a Nobel Prize.
The breakthroughs have kept coming.
Last week, DeepMind announced that researchers from around the world have used AlphaFold to predict the structures of some 200 million proteins from 1 million species, covering just about every protein known to human beings. All of that data is being made freely available on a database set up by DeepMind and its partner, the European Molecular Biology Laboratory’s European Bioinformatics Institute.
Scientists from the University of Virginia School of Medicine and collaborators used the building blocks of life to potentially revolutionize electronics.
The scientists utilized DNA to guide a chemical reaction that would overcome the barrier to Little’s superconductor, which was once thought to be “insurmountable”, a press statement reveals.
In medicine, a prosthesis, or a prosthetic implant, is an artificial device that replaces a missing body part, which may be lost through trauma, disease, or a condition present at birth. A pioneering project to develop advanced pressure sensors for use in robotic systems could transform prosthetics and robotic limbs. The innovative research project aspires to develop sensors that provide enhanced capabilities to robots, helping improve their motor skills and dexterity, through the use of highly accurate pressure sensors that provide haptic feedback and distributed touch.
It is led by the University of the West of Scotland (UWS), Integrated Graphene Ltd, and supported by the Scottish Research Partnership in Engineering (SRPe) and the National Manufacturing Institute for Scotland (NMIS) Industry Doctorate Programme in Advanced Manufacturing. This is not for the first time when the team of highly talented researchers have decided to bring the much needed transformative change in prosthetics and robotic limbs.
The human brain relies on a constant stream of tactile information to carry out basic tasks, like holding a cup of coffee. Yet some of the most advanced motorized limbs — including those controlled solely by a person’s thoughts — don’t provide this sort of feedback. As a result, even state-of-the-art prosthetics can often frustrate their users.