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Nail Polish Dryers Damage DNA and Cause Mutations in Cell Lines

The ultraviolet nail polish drying devices used to cure gel manicures may pose more of a public health concern than previously thought. Researchers at the University of California San Diego studied these ultraviolet (UV) light emitting devices, and found that their use leads to cell death and cancer-causing mutations in human cells.

The devices are a common fixture in nail salons, and generally use a particular spectrum of UV light (340-395nm) to cure the chemicals used in gel manicures. While tanning beds use a different spectrum of UV light (280-400nm) that studies have conclusively proven to be carcinogenic, the spectrum used in the nail dryers has not been well studied.

“If you look at the way these devices are presented, they are marketed as safe, with nothing to be concerned about,” said Ludmil Alexandrov, a professor of bioengineering as well as cellular and molecular medicine at UC San Diego, and corresponding author of the study published Jan. 17 in Nature Communications. “But to the best of our knowledge, no one has actually studied these devices and how they affect human cells at the molecular and cellular levels until now.”

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene

Summary: Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of mice and successfully edit a gene associated with Alzheimer’s disease.

Source: University of Wisconsin-Madison.

Gene therapies have the potential to treat neurological disorders like Alzheimer’s and Parkinson’s diseases, but they face a common barrier — the blood-brain barrier.

New Nuclear Rocket Design to Send Missions to Mars in Just 45 Days

We live in an era of renewed space exploration, where multiple agencies are planning to send astronauts to the Moon in the coming years. This will be followed in the next decade with crewed missions to Mars by NASA and China, who may be joined by other nations before long. These and other missions that will take astronauts beyond Low Earth Orbit (LEO) and the Earth-Moon system require new technologies, ranging from life support and radiation shielding to power and propulsion. And when it comes to the latter, Nuclear Thermal and Nuclear Electric Propulsion (NTP/NEP) is a top contender!

NASA and the Soviet space program spent decades researching nuclear propulsion during the Space Race. A few years ago, NASA reignited its nuclear program for the purpose of developing bimodal nuclear propulsion – a two-part system consisting of an NTP and NEP element – that could enable transits to Mars in 100 days. As part of the NASA Innovative Advanced Concepts (NIAC) program for 2023, NASA selected a nuclear concept for Phase I development. This new class of bimodal nuclear propulsion system uses a “wave rotor topping cycle” and could reduce transit times to Mars to just 45 days.

The proposal, titled “Bimodal NTP/NEP with a Wave Rotor Topping Cycle,” was put forward by Prof. Ryan Gosse, the Hypersonics Program Area Lead at the University of Florida and a member of the Florida Applied Research in Engineering (FLARE) team. Gosse’s proposal is one of 14 selected by the NAIC this year for Phase I development, which includes a $12,500 grant to assist in maturing the technology and methods involved. Other proposals included innovative sensors, instruments, manufacturing techniques, power systems, and more.

Study finds that UV-emitting nail polish dryers damage DNA and cause mutations in cells

The ultraviolet nail polish drying devices used to cure gel manicures may pose more of a public health concern than previously thought. Researchers at the University of California San Diego have studied these ultraviolet (UV) light emitting devices, and found that their use leads to cell death and cancer-causing mutations in human cells.

The devices are a common fixture in nail salons, and generally use a particular spectrum of UV light (340-395nm) to cure the chemicals used in gel manicures. While use a different spectrum of UV light (280-400nm) that studies have conclusively proven to be carcinogenic, the spectrum used in the nail dryers has not been well studied.

“If you look at the way these devices are presented, they are marketed as safe, with nothing to be concerned about,” said Ludmil Alexandrov, a professor of bioengineering as well as cellular and at UC San Diego, and corresponding author of the study published in Nature Communications. “But to the best of our knowledge, no one has actually studied these devices and how they affect at the molecular and cellular levels until now.”

RNA lipid nanoparticle engineering stops liver fibrosis in its tracks, reverses damage

Since the success of the COVID-19 vaccine, RNA therapies have been the object of increasing interest in the biotech world. These therapies work with your body to target the genetic root of diseases and infections, a promising alternative treatment method to that of traditional pharmaceutical drugs.

Lipid nanoparticles (LNPs) have been successfully used in for decades. FDA-approved therapies use them as vehicles for delivering messenger RNA (mRNA), which prompts the cell to make new proteins, and small interfering RNA (siRNA), which instruct the cell to silence or inhibit the expression of certain proteins.

The biggest challenge in developing a successful RNA therapy is its targeted delivery. Research is now confronting the current limitations of LNPs, which have left many diseases without an effective RNA therapy.

Developmental and Synthetic Biology featuring Dr. Michael Levin | The Stem Cell Podcast

In episode 220 of the Stem Cell Podcast, we chat with Dr. Michael Levin, the Director of the Allen Discovery Center and a Distinguished Professor of Biology at Tufts University. He talks about regenerating frog legs, using bioelectricity to direct development, and the potential applications of xenobots.

Roundup Papers:
1) https://go.nature.com/3NR8aaG
2) https://go.nature.com/3NFeGkT
3) https://bit.ly/39tYFiM
4) https://bit.ly/3HrKY0g.

0:00 Intro and Roundup.
38:41 Guest Interview.
#RegenerativeMedicine#MichaelLevin #Xenobots.

Listen on iTunes: https://apple.co/2T8BhPA
Listen on Stitcher: https://bit.ly/3hGwsGA
Listen on Spotify: https://spoti.fi/3xFdENP
Official Website: https://stemcellpodcast.com/
Enjoy the other episodes in our full series playlist here: https://bit.ly/3HdhWzW

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This podcast is brought to you by STEMCELL Technologies!

How bio-inspired materials might inform the design of next-generation computers

Ralph Lydic, professor in the UT Department of Psychology, and Dmitry Bolmatov, a research assistant professor in the UT Department of Physics and Astronomy, are part of a UT/ORNL research team studying how bio-inspired materials might inform the design of next-generation computers. Their results, published recently in the Proceedings of the National Academy of Sciences, could have big implications for both edge computing and human health.

Scientists at ORNL and UT discovered an artificial is capable of long-term potentiation, or LTP, a hallmark of biological learning and memory. This is the first evidence that a cell alone—without proteins or other biomolecules embedded within it—is capable of LTP that persists for many hours. It is also the first identified nanoscale structure in which memory can be encoded.

“When facilities were shut down as a result of COVID, this led us to pivot away from our usual membrane research,” said John Katsaras, a biophysicist in ORNL’s Neutron Sciences Directorate specializing in neutron scattering and the study of biological membranes at ORNL. “Together with postdoc Haden Scott, we decided to revisit a system previously studied by Pat Collier and co-workers, this time with an entirely different electrical stimulation protocol that we termed ‘training.’”.

Ep. 102: Genetic engineering and the biological basis of intelligence. | Steven Hsu

Since the discovery of genetics, people have dreamed of being able to correct diseases, select traits in children before birth, and build better human beings. Naturally, many serious technical and ethical questions surround this endeavor. Luckily, tonights’ guest is as good a guide as we could hope to have.

Dr. Steve Hsu is Professor of Theoretical Physics and of Computational Mathematics, Science, and Engineering at Michigan State University. He has done extensive research in the field of computational genomics, and is the founder of several startups.

#geneticengineering #intelligence