Lifeboat Foundation

Brain-machine interfaces (BMIs) are devices that enable direct communication/translation between biological neuronal networks (e.g. a brain or a spine) and external machines. They are currently being used as a tool for fundamental neuroscience research and also for treating neurological disorders and for manipulating neuro-prosthetic devices. As remarkable as today’s BMIs are, however, the next generation BMIs will require new hardware and software with improved resolution and specificity in order to precisely monitor and control the activities of complex neuronal networks. In this talk, I will describe my group’s effort to develop new neuroelectronic devices enabled by silicon nanotechnology that can serve as high-precision, highly multiplexed interface to neuronal networks. I will then describe the promises, as well as potential pitfalls, of next generation BMIs. Hongkun Park is a Professor of Chemistry and Chemical Biology and a Professor of Physics at Harvard University. He is also an Institute Member of the Broad Institute of Harvard and MIT and a member of the Harvard Center for Brain Science and Harvard Quantum Optics Center. He serves as an associate editor of Nano Letters. His research interests lie in exploring solid-state photonic, optoelectronic, and plasmonic devices for quantum information processing as well as developing new nano-and microelectronic interfaces for living cells, cell networks, and organisms. Awards and honors that he received include the Ho-Am Foundation Prize in Science, NIH Director’s Pioneer Award, and the US Vannevar Bush Faculty Fellowship, the David and Lucile Packard Foundation Fellowship for Science and Engineering, the Alfred P. Sloan Research Fellowship, and the Camille Dreyfus Teacher-Scholar Award. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

In this landmark talk, Peter Diamandis shares how we are rapidly heading towards a human-scale transformation, the next evolutionary step into what he calls a “Meta-Intelligence,” a future in which we are all highly connected — brain to brain via the cloud — sharing thoughts, knowledge and actions.
He highlights the 4 driving forces as well as the 4 steps that is transforming humanity.

In 2014 Fortune Magazine named Peter Diamandis as one of the World’s 50 Greatest Leaders.

Continue reading “Imagining the Future: The Transformation of Humanity | Peter Diamandis | TEDxLA” »

Krishna Shenoy helps to restore lost function for disabled patients by designing prosthetic devices that can translate neural brain activity.

Krishna Shenoy directs the Neural Prosthetic Systems Lab, where his group conducts neuroscience and neuro-engineering research to better understand how the brain controls movement and to design medical systems to assist those with movement disabilities. Shenoy also co-directs the Neural Prosthetics Translational Lab, which uses these advances to help people with severe motor disabilities. Shenoy received his bachelor’s degree in electrical engineering from UC-Irvine and his master’s and doctoral degrees in the same field from MIT. He was a neurobiology postdoctoral fellow at Caltech in Pasadena and then joined Stanford University, where he is a professor of electrical engineering, bioengineering and neurobiology.

We’ve learned about a few techniques in biotechnology already, but the CRISPR-Cas9 system is one of the most exciting ones. Inspired by bacterial immune response to viruses, this site-specific gene editing technique won the Nobel prize in chemistry in 2020, going to Jennifer Doudna and Emmanuelle Charpentier. How did they develop this method? What can it be used for? Let’s get the full story!

Select images provided by BioRender.com.

Continue reading “CRISPR-Cas9 Genome Editing Technology” »

Hear from Nobel laureate Jennifer Doudna on the four ways that CRISPR gene editing technologies will revolutionize healthcare.

In her 31 March talk at the Frontiers Forum, Prof Jennifer Doudna outlined how CRISPR-based therapies are already transforming the lives of patients with previously limited treatment options. She also gave her vision for how her serendipitous discovery will revolutionize healthcare for us all. The session was attended by over 9,200 representatives from science, policy and business across the world.

Continue reading “Jennifer Doudna | Four ways that CRISPR will revolutionize healthcare” »

The DNA-altering technology has revolutionized life sciences research and is making strides in potential one-and-done treatments for sickle cell disease, genetic liver conditions, and more.

Centimeter-scale objects in liquid can be manipulated using the mutual attraction of two arrays of air bubbles in the presence of sound waves.

Assembling small components into structures is a fiddly business often encountered in manufacturing, robotics, and bioengineering. Some existing approaches use magnetic, electrical, or optical forces to move and position objects without physical contact. Now a team has shown that acoustic waves can create attractive forces between centimeter-scale objects in water, enabling one such object to be accurately positioned above another [1]. The scheme uses arrays of tiny, vibrating air bubbles that provide the attractive force. This acoustic method requires only simple equipment and could provide a cheap, versatile, and gentle alternative technique for object manipulation.

Researchers are developing techniques that use acoustic waves to position objects such as colloidal particles or biological cells. Attractive forces are produced by the scattering of sound waves from the objects being manipulated. One limitation of this approach, however, is that positioning is more accurate with waves of higher frequency (and thus smaller wavelength), but higher frequencies are also more strongly absorbed and attenuated by many materials.

For decades, biologists have read and edited DNA, the code of life. Revolutionary developments are giving scientists the power to write it. Instead of tinkering with existing life forms, synthetic biologists may be on the verge of writing the DNA of a living organism from scratch. In the next decade, according to some, we may even see the first synthetic human genome. Join a distinguished group of synthetic biologists, geneticists and bioengineers who are edging closer to breathing life into matter.

This program is part of the Big Ideas Series, made possible with support from the John Templeton Foundation.

Continue reading “It’s Alive, But Is It Life: Synthetic Biology and the Future of Creation” »

This month marks ten years since CRISPR-Cas9 was repurposed as a gene editing system, so we’re looking back at what has been accomplished in a decade of CRISPR editing.