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Archive for the ‘bioengineering’ category: Page 35

Jun 3, 2023

An AAV-CRISPR/Cas9 strategy for gene editing across divergent rodent species

Posted by in categories: bioengineering, biotech/medical, genetics, neuroscience

Crispre cas 9.


A major issue in neuroscience is the poor translatability of research results from preclinical studies in animals to clinical outcomes. Comparative neuroscience can overcome this barrier by studying multiple species to differentiate between species-specific and general mechanisms of neural circuit functioning. Targeted manipulation of neural circuits often depends on genetic dissection, and use of this technique has been restricted to only a few model species, limiting its application in comparative research. However, ongoing advances in genomics make genetic dissection attainable in a growing number of species. To demonstrate the potential of comparative gene editing approaches, we developed a viral-mediated CRISPR/Cas9 strategy that is predicted to target the oxytocin receptor (Oxtr) gene in 80 rodent species. This strategy specifically reduced OXTR levels in all evaluated species (n = 6) without causing gross neuronal toxicity. Thus, we show that CRISPR/Cas9-based tools can function in multiple species simultaneously. Thereby, we hope to encourage comparative gene editing and improve the translatability of neuroscientific research.

The development of comparative gene editing strategies improves the translatability of animal research.

Jun 2, 2023

Plastic-eating bacteria: Genetic engineering and environmental impact

Posted by in categories: bioengineering, genetics

Year 2022 😗😁


Discover how plastic-eating bacteria were discovered and re-engineered to help tackle the worlds plastic problem.

May 31, 2023

Brain Computer Interfaces in 2050: Top 10 Future Technologies

Posted by in categories: augmented reality, bioengineering, business, genetics, robotics/AI, transhumanism

https://youtu.be/289mVc7PDsU

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May 28, 2023

Penn State researchers create first protein-based nano-computing agent

Posted by in categories: bioengineering, biotech/medical, computing, nanotechnology

The first protein-based nano-computing agent that functions as a circuit has been created by Penn State researchers. The milestone puts them one step closer to developing next-generation cell-based therapies to treat diseases like diabetes and cancer.

Traditional synthetic biology approaches for cell-based therapies, such as ones that destroy cancer cells or encourage tissue regeneration after injury, rely on the expression or suppression of proteins that produce a desired action within a cell. This approach can take time (for proteins to be expressed and degrade) and cost cellular energy in the process. A team of Penn State College of Medicine and Huck Institutes of the Life Sciences researchers are taking a different approach.

“We’re engineering proteins that directly produce a desired action,” said Nikolay Dokholyan, G. Thomas Passananti Professor and vice chair for research in the Department of Pharmacology. “Our protein-based devices or nano-computing agents respond directly to stimuli (inputs) and then produce a desired action (outputs).”

May 27, 2023

Gene Editing Gets a Triple Boost: “Happy Accident” Leads to Enhanced CRISPR Efficiency

Posted by in categories: bioengineering, biotech/medical, genetics

Scientists have enhanced the efficiency of CRISPR/Cas9 gene editing by threefold using interstrand crosslinks, without resorting to viral material for delivery. This approach boosts the cell’s natural repair mechanisms, allowing for more accurate and efficient gene editing, potentially improving disease research and preclinical work.

Gene editing is a powerful method for both research and therapy. Since the advent of the Nobel Prize-winning CRISPR/Cas9 technology, a quick and accurate tool for genome editing discovered in 2012, scientists have been working to explore its capabilities and boost its performance.

Researchers in the University of California, Santa Barbara biologist Chris Richardson’s lab have added to that growing toolbox, with a method that increases the efficiency of CRISPR/Cas9 editing without the use of viral material to deliver the genetic template used to edit the target genetic sequence. According to their new paper published in the journal Nature Biotechnology, their method stimulates homology-directed repair (a step in the gene editing process) by approximately threefold “without increasing mutation frequencies or altering end-joining repair outcomes.”

May 27, 2023

Protein-based nano-computer evolves in its ability to influence cell behavior

Posted by in categories: bioengineering, biotech/medical, computing, nanotechnology

The first protein-based nano-computing agent that functions as a circuit has been created by Penn State researchers. The milestone puts them one step closer to developing next-generation cell-based therapies to treat diseases like diabetes and cancer.

Traditional synthetic biology approaches for cell-based therapies, such as ones that destroy or encourage tissue regeneration after injury, rely on the expression or suppression of proteins that produce a desired action within a cell. This approach can take time (for proteins to be expressed and degrade) and cost cellular energy in the process. A team of Penn State College of Medicine and Huck Institutes of the Life Sciences researchers are taking a different approach.

“We’re engineering proteins that directly produce a desired action,” said Nikolay Dokholyan, G. Thomas Passananti Professor and vice chair for research in the Department of Pharmacology. “Our protein-based devices or nano-computing agents respond directly to stimuli (inputs) and then produce a desired action (outputs).”

May 25, 2023

China faces new Covid wave from XBB variant that could peak at 65 million cases a week

Posted by in categories: bioengineering, biotech/medical, genetics, government

So it is confirmed that the new variant of covid 19 virus is here but the actual spike now is in China. But will most likely spread globally much how previous viruses have done. Be sure to be prepared for another pandemic. Anyway what may be the possible cure would be new bioengineering techniques with crispr to eventually be immune to the virus like I have posted in some genetically engineered cells recently were made. But rest assured this could lead to a global pandemic because the current variant is taxing our current vaccination measures.


The country once had some of the harshest Covid restrictions on the planet, but the response from the government and the public is relatively muted this time.

May 25, 2023

Decoding the Aging Process: The Impact of Blood Dilution on Biological Age (Irina Conboy at EARD)

Posted by in categories: bioengineering, biotech/medical, life extension, neuroscience

In short blood dilution is very, very good for you.


In this talk, Dr. Irina Conboy discusses the role of repair and regeneration in lifespan and healthspan, contending that these factors, rather than entropy and time progression, truly govern our aging process. She describes the research her team is pursuing, investigating whether improving the efficiency of bodily repair in older individuals could effectively make them younger. She suggests that biological age could potentially be reversed and discusses heterochronic parabiosis and plasma dilution as potential ways to accomplish that. Conboy highlights recent research suggesting that old blood has a greater impact on cellular health and function than young blood. She presents her team’s experimental research on the rejuvenation effects of plasma dilution, demonstrating its significant impact on reducing senescence, neuroinflammation, and promoting neurogenesis in the brains of old mice.

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May 23, 2023

The role of Newtic1 protein in limb regeneration in adult newts

Posted by in categories: bioengineering, biotech/medical, genetics, life extension

Year 2022 This new protein Newtic1 holds promise to fully understanding limb regeneration in humans. Still though genetic engineering will be needed to fully integrate the ability for limb and body part regeneration.


The animal kingdom exhibits a plethora of unique and surprising phenomena or abilities that include, for some animals, the ability to regenerate body parts irrespective of age. Now, researchers from Japan have discovered that the mechanisms behind this peculiar ability in newts have a few surprises of their own.

May 22, 2023

Quantum Biology: Unlocking the Mysteries of How Life Works

Posted by in categories: bioengineering, biotech/medical, genetics, quantum physics

Quantum biology explores how quantum effects influence biological processes, potentially leading to breakthroughs in medicine and biotechnology. Despite the assumption that quantum effects rapidly disappear in biological systems, research suggests these effects play a key role in physiological processes. This opens up the possibility of manipulating these processes to create non-invasive, remote-controlled therapeutic devices. However, achieving this requires a new, interdisciplinary approach to scientific research.

Imagine using your cell phone to control the activity of your own cells to treat injuries and diseases. It sounds like something from the imagination of an overly optimistic science fiction writer. But this may one day be a possibility through the emerging field of quantum biology.

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