While DNA provides the genetic recipe book for biological form and function, it is the job of the body’s proteins to carry out the complex commands dictated by DNA’s genetic code.
Stuart Lindsay, a researcher at the Biodesign Institute at ASU, has been at the forefront of efforts to improve rapid DNA sequencing and has more recently applied his talents to explore the much thornier problem of sequencing protein molecules, one molecule at a time.
In a new overview article, Lindsay’s efforts are described along with those of international colleagues, who are applying a variety of innovative strategies for protein sequencing at the single-cell, and even single-molecule level.
A research team from the University of Massachusetts Amherst has created an electronic microsystem that can intelligently respond to information inputs without any external energy input, much like a self-autonomous living organism. The microsystem is constructed from a novel type of electronics that can process ultralow electronic signals and incorporates a device that can generate electricity “out of thin air” from the ambient environment.
The groundbreaking research was published June 7 in the journal Nature Communications.
Jun Yao, an assistant professor in the electrical and computer engineering (ECE) and an adjunct professor in biomedical engineering, led the research with his longtime collaborator, Derek R. Lovley, a Distinguished Professor in microbiology.
Imagine you’re a fisherman living by a lake with a rowboat. Every day, you row out on the calm waters and life is good. But then your family grows, and you need more fish, so you go to the nearby river. Then, you realize you go farther and faster on the river. You can’t take your little rowboat out there—it’s not built for those currents. So, you learn everything you can about how rivers work and build a better boat. Life is good again…until you realize you need to go farther still, out on the ocean. But ocean rules are nothing like river rules. Now you have to learn how ocean currents work, and then design something even more advanced that can handle that new space.
Communication frequencies are just like those water currents. And the boats are just like the tools we build to communicate. The challenge is twofold: learning enough about the nature of each frequency and then engineering novel devices that will work within them. In a recent paper published in Proceedings of the IEEE, the flagship publication of the largest engineering society in the world, one USC Viterbi School of Engineering researcher has done just that for the next generation of cellular networks—6G.
Andy Molisch, professor of electrical and computer engineering at USC Viterbi and the holder of the Solomon Golomb—Andrew and Erna Viterbi Chair, together with colleagues from Lund University in Sweden, New Zealand Telecom, and King’s College London, explained that we have more options for communications at 6G frequency than previously thought. Think of it as something like early explorers suddenly discovering the gulf stream.
A new technology could dramatically improve the safety of lithium-ion batteries that operate with gas electrolytes at ultra-low temperatures. Nanoengineers at the University of California San Diego developed a separator—the part of the battery that serves as a barrier between the anode and cathode—that keeps the gas-based electrolytes in these batteries from vaporizing. This new separator could, in turn, help prevent the buildup of pressure inside the battery that leads to swelling and explosions.
“By trapping gas molecules, this separator can function as a stabilizer for volatile electrolytes,” said Zheng Chen, a professor of nanoengineering at the UC San Diego Jacobs School of Engineering who led the study.
The new separator also boosted battery performance at ultra–low temperatures. Battery cells built with the new separator operated with a high capacity of 500 milliamp-hours per gram at-40 C, whereas those built with a commercial separator exhibited almost no capacity. The battery cells still exhibited high capacity even after sitting unused for two months—a promising sign that the new separator could also prolong shelf life, the researchers said.
Check out this short educational video in which I explain some super exciting research in the area of nanotechnology: gigadalton-scale DNA origami! I specifically discuss a journal article by Wagenbauer et al. titled “Gigadalton-scale shape-programmable DNA assemblies”.
Though I am not involved in this research myself, I have worked in adjacent areas such as synthetic biology, nanotechnology-based tools for neuroscience, and gene therapy. I am endlessly fascinated by DNA origami and would love to use it in my own research at some point in the future.
I am a PhD candidate at Washington University in St. Louis and the CTO of the startup company Conduit Computing. I am also a published science fiction writer and a futurist. To learn more about me, check out my website: https://logancollinsblog.com/.
Reprogramming of ordinary somatic cells into induced pluripotent stem cells (iPSCs) was initially thought to be a way to obtain all of the patient matched cells needed for tissue engineering or cell therapies. A great deal of work has gone towards realizing that goal over the past fifteen years or so; the research community isn’t there yet, but meaningful progress has taken place. Of late, another line of work has emerged, in that it might be possible to use partial reprogramming as a basis for therapy, delivering reprogramming factors into animals and humans in order to improve tissue function, without turning large numbers of somatic cells into iPSCs and thus risking cancer or loss of tissue structure and function.
Reprogramming triggers some of the same mechanisms of rejuvenation that operate in the developing embryo, removing epigenetic marks characteristic of aged tissues, and restoring youthful mitochondrial function. It cannot do much for forms of damage such as mutations to nuclear DNA or buildup of resilient metabolic waste, but the present feeling is there is nonetheless enough of a potential benefit to make it worth developing this approach to treatments for aging. Some groups have shown that partial reprogramming — via transient expression of reprogramming factors — can reverse functional losses in cells from aged tissues without making those cells lose their differentiated type. But this is a complicated business. Tissues are made up of many cell types, all of which can need subtly different approaches to safe reprogramming.
Today’s open access preprint is illustrative of the amount of work that lies ahead when it comes to the exploration of in vivo reprogramming. Different cell types behave quite differently, will require different recipes and approaches to reprogramming, different times of exposure, and so forth. It makes it very hard to envisage a near term therapy that operates much like present day gene therapies, meaning one vector and one cargo, as most tissues are comprised of many different cell types all mixed in together. On the other hand, the evidence to date, including that in the paper here, suggests that there are ways to create the desired rejuvenation of epigenetic patterns and mitochondrial function without the risk of somatic cells dedifferentiating into stem cells.
The idea is simple: decades of research have found certain genes that seem to increase the chance of Alzheimer’s and other dementias. The numbers range over hundreds. Figuring out how each connects or influences another—if at all—takes years of research in individual labs. What if scientists unite, tap into a shared resource, and collectively solve the case of why Alzheimer’s occurs in the first place?
The initiative’s secret weapon is induced pluripotent stem cells, or iPSCs. Similar to most stem cells, they have the ability to transform into anything—a cellular genie, if you will. iPSCs are reborn from regular adult cells, such as skin cells. When transformed into a brain cell, however, they carry the original genes of their donor, meaning that they harbor the original person’s genetic legacy—for example, his or her chance of developing Alzheimer’s in the first place. What if we introduce Alzheimer’s-related genes into these reborn stem cells, and watch how they behave?
By studying these iPSCs, we might be able to follow clues that lead to the genetic causes of Alzheimer’s and other dementias—paving the road for gene therapies to nip them in the bud.
CRISPR-based technologies offer enormous potential to benefit human health and safety, from disease eradication to fortified food supplies. As one example, CRISPR-based gene drives, which are engineered to spread specific traits through targeted populations, are being developed to stop the transmission of devastating diseases such as malaria and dengue fever.
But many scientists and ethicists have raised concerns over the unchecked spread of gene drives. Once deployed in the wild, how can scientists prevent gene drives from uncontrollably spreading across populations like wildfire?
Now, scientists at the University of California San Diego and their colleagues have developed a gene drive with a built-in genetic barrier that is designed to keep the drive under control. Led by molecular geneticist Omar Akbari’s lab, the researchers engineered synthetic fly species that, upon release in sufficient numbers, act as gene drives that can spread locally and be reversed if desired.
Today, Sunday, May 30, 2021, at 1 p.m. Pacific Time, join us for a U.S. Transhumanist Party Virtual Enlightenment Salon with Ryan O’Shea, as we discuss the state of the transhumanist movement, life-extension advocacy, biohacking, Ryan’s Future Grind podcast, and more!
Watch on YouTube here:. You will be able to post questions and comments in the live YouTube chat.
On Sunday, May 30, 2021, at 1 p.m. U.S. Pacific Time, the U.S. Transhumanist Party invites Ryan O’Shea for a Virtual Enlightenment Salon to discuss a wide array of subjects related to transhumanism, including the state of the contemporary transhumanist movement, Ryan O’Shea’s Future Grind podcast, biohacking, the Human Augmentation Institute and the Human Augmentation Code of Ethics, Ryan O’Shea’s media work with the Lifespan Extension Advocacy Foundation with the goal of popularizing life-extension science, how to respond to common criticisms of transhumanism, thoughts on consciousness and free will, and strategies for advancing the transhumanist movement in the future.
Ryan O’Shea is an entrepreneur and futurist speaker from Pittsburgh, Pennsylvania. He is the host of Future Grind — https://futuregrind.org/ — a multimedia production company that seeks to increase technoliteracy and democratize access to information about emerging technologies, enabling more voices to be a part of the societal conversation surrounding technology. Ryan is also a founder of the Human Augmentation Institute, an organization focused on upholding bodily autonomy and ensuring that any efforts in human augmentation are done ethically, safely, and responsibly. He also serves as the spokesperson for Grindhouse Wetware, a group specializing in technology to augment human capabilities. In 2017, Ryan co-founded a National Institutes of Health and National Science Foundation-supported artificial intelligence startup that is working to use machine learning and automated just-in-time intervention for behavior change. Ryan has represented NASA and CalTech’s Jet Propulsion Laboratory as a Solar System Ambassador and serves both as a World Economic Forum Global Shaper and an ambassador for Pittsburgh AI. He is a graduate of the University of Pittsburgh and currently serves on the boards of multiple non-profit organizations.
